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公开(公告)号:US20160369002A1
公开(公告)日:2016-12-22
申请号:US15190337
申请日:2016-06-23
Applicant: INNATE PHARMA
Inventor: Laurent GAUTHIER , Nadia Anceriz , Ariane Morel , Benjamin Rossi
IPC: C07K16/28
CPC classification number: C07K16/2896 , C07K16/2803 , C07K16/2809 , C07K16/283 , C07K16/2866 , C07K16/2887 , C07K2317/31 , C07K2317/522 , C07K2317/524 , C07K2317/526 , C07K2317/565 , C07K2317/622 , C07K2317/71 , C07K2317/732 , C07K2317/75 , C07K2317/92 , C07K2319/30 , A61K39/001102 , A61K39/001104
Abstract: Multispecific proteins that bind and specifically redirect NK cells to lyse a target cell of interest are provided without non-specific activation of NK cells in absence of target cells. The proteins have utility in the treatment of disease, notably cancer or infectious disease.
Abstract translation: 在不存在靶细胞的情况下,提供结合并特异性地重定向NK细胞以裂解感兴趣的靶细胞的多特异性蛋白质而没有NK细胞的非特异性激活。 这些蛋白质可用于治疗疾病,特别是癌症或感染性疾病。