公开(公告)号：US20240392008A1

公开(公告)日：2024-11-28

申请号：US18568310

申请日：2022-06-08

Applicant: INNATE PHARMA

Inventor： Laurent GAUTHIER ,  Yannis MOREL ,  Olivier DEMARIA

IPC: C07K16/28 ,  A61K38/00 ,  C07K14/55

Abstract: Multispecific proteins that bind NKp46 and specifically redirect effector cells to lyse a target cell of interest via multiple receptors are provided. The proteins have utility in the treatment of disease, notably cancer or infectious disease.

公开(公告)号：US20170198038A1

公开(公告)日：2017-07-13

申请号：US15321650

申请日：2015-06-23

Applicant: INNATE PHARMA

Inventor： Laurent GAUTHIER ,  Nadia ANCERIZ ,  Ariane MOREL ,  Benjamin ROSSI

IPC: C07K16/28

CPC classification number: C07K16/2803 ,  C07K16/2866 ,  C07K2317/31 ,  C07K2317/71 ,  C07K2317/92 ,  C07K2319/30

Abstract: Multispecific proteins that bind and specifically redirect NK cells to lyse a target cell of interest are provided without non-specific activation of NK cells in absence of target cells. The proteins have utility in the treatment of disease, notably cancer or infectious disease.

公开(公告)号：US20240199750A1

公开(公告)日：2024-06-20

申请号：US18283385

申请日：2022-03-24

Applicant: INNATE PHARMA

Inventor： Stephanie CORNEN ,  Laurent GAUTHIER ,  Yannis MOREL ,  Olivier DEMARIA

IPC: C07K16/28 ,  A61K39/00 ,  A61P35/00 ,  C07K14/54 ,  C07K14/55 ,  C07K14/56 ,  C07K14/565 ,  C12N5/0783

CPC classification number: C07K16/2866 ,  A61P35/00 ,  C07K14/54 ,  C07K14/5418 ,  C07K14/5434 ,  C07K14/5443 ,  C07K14/55 ,  C07K14/56 ,  C07K14/565 ,  C07K16/2803 ,  C07K16/283 ,  C12N5/0646 ,  A61K39/00 ,  A61K2039/505 ,  C07K2317/31 ,  C07K2317/92 ,  C07K2319/30

Abstract: Multi-specific proteins that bind to NKp46 and a cytokine receptor on NK cells, and optionally that further bind CD16A on NK cells, and that also bind to an antigen of interest (e.g. a cancer antigen) on a target cell (e.g. a cancer cell). The multi-specific proteins are capable of increasing NK cell cytotoxicity toward a target cell that expresses the antigen of interest (e.g., a cell that contributes to disease, a cancer cell).

公开(公告)号：US20220135676A1

公开(公告)日：2022-05-05

申请号：US17530510

申请日：2021-11-19

Applicant: INNATE PHARMA

Inventor： Laurent GAUTHIER ,  Benjamin ROSSI

IPC: C07K16/28 ,  C07K16/00 ,  C07K16/30

Abstract: Multimeric multispecific proteins formed from dimerization between CH1 and CK domains and that bind two target antigens are provided. The proteins have advantages in production and in the treatment of disease, notably cancer or infectious disease.

公开(公告)号：US20240141042A1

公开(公告)日：2024-05-02

申请号：US18490804

申请日：2023-10-20

Applicant: INNATE PHARMA

Inventor： Laurent GAUTHIER ,  Nadia ANCERIZ ,  Ariane MOREL ,  Benjamin ROSSI

IPC: C07K16/28

CPC classification number: C07K16/2803 ,  C07K16/2866 ,  C07K2317/31 ,  C07K2317/71 ,  C07K2317/92 ,  C07K2319/30

Abstract: Multispecific proteins that bind and specifically redirect NK cells to lyse a target cell of interest are provided without non-specific activation of NK cells in absence of target cells. The proteins have utility in the treatment of disease, notably cancer or infections disease.

公开(公告)号：US20220213202A1

公开(公告)日：2022-07-07

申请号：US17566142

申请日：2021-12-30

Applicant: INNATE PHARMA ,  SANOFI

Inventor： Céline AMARA ,  Céline NICOLAZZI ,  Marielle CHIRON ,  Francis DUFFIEUX ,  Jochen BENINGA ,  Angela VIRONE-ODDOS ,  Laurent GAUTHIER ,  Ariane THIELENS ,  Benjamin ROSSI

IPC: C07K16/28 ,  A61P35/02

Abstract: The present disclosure relates to multifunctional binding proteins comprising a first and a second antigen binding domains (ABDs) and all or part of an immunoglobulin Fc region or variant thereof, wherein the first ABD binds specifically to human CD123 and the second ABD binds specifically to human NKp46 and wherein all or part of the immunoglobulin Fc region or variant thereof to a human Fc-γ receptor.
The disclosure also relates to methods for making said binding proteins, compositions thereof, and their uses, including the treatment or prevention of proliferative disorders, including Acute Myeloid Leukemia (AML) and myelodysplastic syndromes (MDS).

公开(公告)号：US20200048345A1

公开(公告)日：2020-02-13

申请号：US15738506

申请日：2016-06-23

Applicant: INNATE PHARMA

Inventor： Laurent GAUTHIER ,  Benjamin ROSSI

IPC: C07K16/28

Abstract: Multimeric multispecific proteins formed from dimerization between CH1 and CK domains and that bind two target antigens are provided. The proteins have advantages in production and in the treatment of disease, notably cancer or infectious disease.

公开(公告)号：US20190048093A1

公开(公告)日：2019-02-14

申请号：US16173114

申请日：2018-10-29

Applicant: INNATE PHARMA

Inventor： Laurent GAUTHIER ,  Nadia ANCERIZ ,  Ariane MOREL ,  Benjamin ROSSI

IPC: C07K16/28

Abstract: Multispecific proteins that bind and specifically redirect NK cells to lyse a target cell of interest are provided without non-specific activation of NK cells in absence of target cells. The proteins have utility in the treatment of disease, notably cancer or infectious disease.

公开(公告)号：US20170210802A1

公开(公告)日：2017-07-27

申请号：US15321674

申请日：2015-06-23

Applicant: INNATE PHARMA

Inventor： Laurent GAUTHIER ,  Benjamin ROSSI

IPC: C07K16/28 ,  C07K16/30

CPC classification number: C07K16/2803 ,  C07K16/00 ,  C07K16/2809 ,  C07K16/30 ,  C07K2317/31 ,  C07K2317/52 ,  C07K2317/522 ,  C07K2317/526 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/622 ,  C07K2317/71 ,  C07K2317/732 ,  C07K2317/76 ,  C07K2317/92

Abstract: Multimeric multispecific proteins formed from dimerization between CH1 and CK domains and that bind two target antigens are provided. The proteins have advantages in production and in the treatment of disease, notably cancer or infectious disease.

公开(公告)号：US20240034816A1

公开(公告)日：2024-02-01

申请号：US18469947

申请日：2023-09-19

Applicant: SANOFI ,  INNATE PHARMA

Inventor： Nicolas GOURDIN ,  Laurent GAUTHIER ,  Alexandre TANG ,  Marielle CHIRON ,  Angela VIRONE-ODDOS ,  Alessandro MASIERO ,  Jochen BENINGA ,  Ingo FOCKEN ,  Sambasiva RAO ,  Yanfeng ZHOU ,  Leila SEVIGNY

IPC: C07K16/46 ,  C12N15/63 ,  A61P35/00

CPC classification number: C07K16/468 ,  C12N15/63 ,  A61P35/00 ,  C07K2317/565 ,  C07K2317/522 ,  C07K2317/524 ,  C07K2317/526 ,  C07K2317/53 ,  C07K2317/41 ,  C07K2317/14 ,  C07K2317/31

Abstract: The present disclosure relates to multifunctional binding proteins comprising a first and a second antigen binding domains (ABDs) and all or part of an immunoglobulin Fc region or variant thereof, wherein the first ABD binds specifically to human BCMA and the second ABD binds specifically to human NKp46 and wherein all or part of the immunoglobulin Fc region or variant thereof bind to a human Fc-γ receptor.
The disclosure also relates to methods for making said binding proteins, compositions thereof, and their uses, including the treatment or prevention of proliferative disorders, including multiple myeloma (MM).