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公开(公告)号：US11267897B2
公开(公告)日：2022-03-08
申请号：US16173114
申请日：2018-10-29
Applicant: INNATE PHARMA
Inventor： Laurent Gauthier , Nadia Anceriz , Ariane Morel , Benjamin Rossi
Abstract: Multispecific proteins that bind and specifically redirect NK cells to lyse a target cell of interest are provided without non-specific activation of NK cells in absence of target cells. The proteins have utility in the treatment of disease, notably cancer or infectious disease.
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公开(公告)号：US11891444B2
公开(公告)日：2024-02-06
申请号：US17315547
申请日：2021-05-10
Applicant: INNATE PHARMA
Inventor： Laurent Gauthier , Nadia Anceriz , Ariane Morel , Benjamin Rossi
CPC classification number: C07K16/2803 , C07K16/2809 , C07K16/2887 , C07K16/468 , C12N5/10 , C12N15/00 , C12N15/64 , C12N15/66 , C07K2317/24 , C07K2317/31 , C07K2317/33 , C07K2317/34 , C07K2317/526 , C07K2317/622 , C07K2317/732 , C07K2317/92 , C12N2511/00 , C12N2523/00
Abstract: NKp46-binding immunoglobulin variable regions, and proteins such as antibodies and multispecific proteins that comprise the variable regions are provided. The proteins can bind and specifically redirect NK cells to lyse a target cell of interest. The proteins have utility in the treatment of disease, notably cancer or infectious disease.
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公开(公告)号：US12252543B2
公开(公告)日：2025-03-18
申请号：US16173150
申请日：2018-10-29
Applicant: INNATE PHARMA
Inventor： Laurent Gauthier , Nadia Anceriz , Ariane Morel , Benjamin Rossi
IPC: C07H21/00 , A61K39/00 , C07K16/28 , C12N15/86 , C12N5/0783
Abstract: Multispecific proteins that bind and specifically redirect NK cells to lyse a target cell of interest are provided without non-specific activation of NK cells in absence of target cells. The proteins have utility in the treatment of disease, notably cancer or infectious disease.
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公开(公告)号：US11377492B2
公开(公告)日：2022-07-05
申请号：US16478863
申请日：2018-01-22
Applicant: INNATE PHARMA
Inventor： Nadia Anceriz , Mathieu Blery , Laurent Gauthier , Carine Paturel
IPC: C07K16/30 , A61P35/00 , C07K16/28 , A61K47/68 , G01N33/569
Abstract: The present invention provides antigen-binding proteins capable of binding to NKp46 polypeptides. The antigen-binding proteins have increased activity in the treatment of disorders characterized by NKp46-expressing cells, particularly tumor cells.
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公开(公告)号：US11001629B2
公开(公告)日：2021-05-11
申请号：US16066688
申请日：2016-12-20
Applicant: INNATE PHARMA
Inventor： Laurent Gauthier , Nadia Anceriz , Ariane Morel , Benjamin Rossi
Abstract: NKp-46-binding immunoglobulin variable regions, and proteins such as antibodies and multispecific proteins that comprise the variable regions are provided. The proteins can bind and specifically redirect NK cells to lyse a target cell of interest. The proteins have utility in the treatment of disease, notably cancer or infectious disease.
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Patent Agency Ranking
公开(公告)号：US20190055315A1
公开(公告)日：2019-02-21
申请号：US16173150
申请日：2018-10-29
Applicant: INNATE PHARMA
Inventor： Laurent Gauthier , Nadia Anceriz , Ariane Morel , Benjamin Rossi
IPC: C07K16/28
Abstract: Multispecific proteins that bind and specifically redirect NK cells to lyse a target cell of interest are provided without non-specific activation of NK cells in absence of target cells. The proteins have utility in the treatment of disease, notably cancer or infectious disease.
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公开(公告)号：US10113003B2
公开(公告)日：2018-10-30
申请号：US15190337
申请日：2016-06-23
Applicant: INNATE PHARMA
Inventor： Laurent Gauthier , Nadia Anceriz , Ariane Morel , Benjamin Rossi
Abstract: Multispecific proteins that bind and specifically redirect NK cells to lyse a target cell of interest are provided without non-specific activation of NK cells in absence of target cells. The proteins have utility in the treatment of disease, notably cancer or infectious disease.
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公开(公告)号：US11845795B2
公开(公告)日：2023-12-19
申请号：US16677709
申请日：2019-11-08
Applicant: INNATE PHARMA
Inventor： Laurent Gauthier , Nadia Anceriz , Ariane Morel , Benjamin Rossi
IPC: C07K16/28
CPC classification number: C07K16/2803 , C07K16/2866 , C07K2317/31 , C07K2317/71 , C07K2317/92 , C07K2319/30
Abstract: Multispecific proteins that bind and specifically redirect NK cells to lyse a target cell of interest are provided without non-specific activation of NK cells in absence of target cells. The proteins have utility in the treatment of disease, notably cancer or infectious disease.
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公开(公告)号：US10736963B2
公开(公告)日：2020-08-11
申请号：US15747190
申请日：2016-07-04
Applicant: INNATE PHARMA
Inventor： Nadia Anceriz , Cecile Bonnafous , Arnaud Dujardin , Carine Paturel
IPC: A61K39/00 , A61K39/395 , G01N33/566 , G01N33/574 , C07K16/28 , A61P35/00
Abstract: The present invention relates to methods for detecting and monitoring NK cells in paraffin-embedded tissue samples. Also provided are antibodies, antibody fragments, and derivatives thereof that specifically bind to NKp46 present on the surface of NK cells in paraffin-embedded tissue samples.
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公开(公告)号：US10519234B2
公开(公告)日：2019-12-31
申请号：US15321650
申请日：2015-06-23
Applicant: INNATE PHARMA
Inventor： Laurent Gauthier , Nadia Anceriz , Ariane Morel , Benjamin Rossi
IPC: C07K16/28
Abstract: Multispecific proteins that bind and specifically redirect NK cells to lyse a target cell of interest are provided without non-specific activation of NK cells in absence of target cells. The proteins have utility in the treatment of disease, notably cancer or infectious disease.
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