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公开(公告)号：US20160102092A1
公开(公告)日：2016-04-14
申请号：US14972984
申请日：2015-12-17
申请人： Nicole Buschmann , Robin Alec Fairhurst , Pascal Furet , Thomas Knöpfel , Catherine Leblanc , Lv Liao , Robert Mah , Pierre Nimsgern , Sebastien Ripoche , Jing Xiong , Bo Han , Can Wang , Xianglin Zhao
发明人： Nicole Buschmann , Robin Alec Fairhurst , Pascal Furet , Thomas Knöpfel , Catherine Leblanc , Lv Liao , Robert Mah , Pierre Nimsgern , Sebastien Ripoche , Jing Xiong , Bo Han , Can Wang , Xianglin Zhao
IPC分类号： C07D471/04 , C07D519/00 , C07D498/04
CPC分类号： C07D471/04 , A61K31/444 , A61K31/497 , A61K31/506 , A61K31/5377 , A61K31/5383 , A61K31/541 , A61K31/55 , C07D498/04 , C07D519/00
摘要： The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof; a method for manufacturing said compound, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition comprising said compound.
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公开(公告)号：US20150119385A1
公开(公告)日：2015-04-30
申请号：US14522721
申请日：2014-10-24
申请人： Nicole Buschmann , Robin Alec Fairhurst , Pascal Furet , Thomas Knöpfel , Catherine Leblanc , Lv Liao , Robert Mah , Pierre Nimsgern , Sebastien Ripoche , Jing Xiong , Bo Han , Can Wang , Xianglin Zhao
发明人： Nicole Buschmann , Robin Alec Fairhurst , Pascal Furet , Thomas Knöpfel , Catherine Leblanc , Lv Liao , Robert Mah , Pierre Nimsgern , Sebastien Ripoche , Jing Xiong , Bo Han , Can Wang , Xianglin Zhao
IPC分类号： C07D471/04 , A61K31/506 , C07D498/04 , A61K31/55 , A61K31/497 , A61K31/5377 , C07D519/00 , A61K31/541 , A61K31/444 , A61K31/5383
CPC分类号： C07D471/04 , A61K31/444 , A61K31/497 , A61K31/506 , A61K31/5377 , A61K31/5383 , A61K31/541 , A61K31/55 , C07D498/04 , C07D519/00
摘要： The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof; a method for manufacturing said compound, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition comprising said compound.
摘要翻译： 本发明提供式（I）化合物或其药学上可接受的盐; 制备所述化合物的方法及其治疗用途。 本发明还提供药理学活性剂和包含所述化合物的药物组合物的组合。
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公开(公告)号：US08431703B2
公开(公告)日：2013-04-30
申请号：US12096448
申请日：2006-12-07
IPC分类号： C07D471/02 , A61K31/44
CPC分类号： C07D471/04
摘要： There are provided according to the invention compounds of formula (I) in free ors salt form, wherein R1, R2, R4, R5, R6, A, D, X, W, m and n are as described in the specification, process for preparing them, and their use as pharmaceuticals.
摘要翻译： 根据本发明，提供游离盐形式的式（I）化合物，其中R 1，R 2，R 4，R 5，R 6，A，D，X，W，m和n如说明书中所述， 准备他们，并用作药物。
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公开(公告)号：US20100087432A1
公开(公告)日：2010-04-08
申请号：US11720786
申请日：2005-12-12
IPC分类号： A61K31/5377 , C07D215/20 , C07D413/12 , C07D403/10 , A61K31/4709 , A61K31/497 , A61P37/06
CPC分类号： C07D401/06 , C07D207/34 , C07D405/04
摘要： There are provided according to the invention compounds of formula (I) as CRTh2 antagonists. In free or salt form, wherein R3, R4, R5, R6, Q, W and n are as described in the specification, process for preparing them, and their use as pharmaceuticals.
摘要翻译： 根据本发明提供式（I）化合物作为CRTh2拮抗剂。 游离或盐形式，其中R3，R4，R5，R6，Q，W和n如说明书中所述，其制备方法及其作为药物的用途。
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公开(公告)号：US20080114022A1
公开(公告)日：2008-05-15
申请号：US11597781
申请日：2005-06-16
申请人： Kamlesh Jagdis Bala , Catherine Leblanc , David Andrew Sandham , Katharine Louise Turner , Simon James Watson , Lyndon Nigel Brown , Brian Cox
发明人： Kamlesh Jagdis Bala , Catherine Leblanc , David Andrew Sandham , Katharine Louise Turner , Simon James Watson , Lyndon Nigel Brown , Brian Cox
IPC分类号： A61K31/4745 , C07D471/02
CPC分类号： C07D471/04 , A61K31/437 , A61K45/06
摘要： There are provided according to the invention compounds of formula (I), in free or salt form, wherein R1, R2, R3, R4, R5, R6, Q, W, X, m, n and p are as described in the specification, process for preparing them, and their use as pharmaceuticals.
摘要翻译： 根据本发明，提供游离或盐形式的式（I）化合物，其中R 1，R 2，R 3，R 4，R 5，R 6，Q，W，X，m，n和p如说明书 制备方法，以及作为药物的用途。
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公开(公告)号：US09266883B2
公开(公告)日：2016-02-23
申请号：US14522721
申请日：2014-10-24
申请人： Nicole Buschmann , Robin Alec Fairhurst , Pascal Furet , Thomas Knöpfel , Catherine Leblanc , Lv Liao , Robert Mah , Pierre Nimsgern , Sebastien Ripoche , Jing Xiong , Bo Han , Can Wang , Xianglin Zhao
发明人： Nicole Buschmann , Robin Alec Fairhurst , Pascal Furet , Thomas Knöpfel , Catherine Leblanc , Lv Liao , Robert Mah , Pierre Nimsgern , Sebastien Ripoche , Jing Xiong , Bo Han , Can Wang , Xianglin Zhao
IPC分类号： C07D471/04 , C07D498/04 , C07D519/00 , A61K31/444 , A61K31/497 , A61K31/506 , A61K31/5377 , A61K31/5383 , A61K31/541 , A61K31/55
CPC分类号： C07D471/04 , A61K31/444 , A61K31/497 , A61K31/506 , A61K31/5377 , A61K31/5383 , A61K31/541 , A61K31/55 , C07D498/04 , C07D519/00
摘要： The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof; a method for manufacturing said compound, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition comprising said compound.
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公开(公告)号：US08314112B2
公开(公告)日：2012-11-20
申请号：US12351438
申请日：2009-01-09
IPC分类号： C07D487/04 , A61K31/519 , C07D471/04 , A61K31/437
CPC分类号： C07D471/04 , C07D487/04
摘要： Compounds of formula I in free or salt or solvate form, wherein X, T1, T3 and T4 have the meanings as indicated in the specification, are useful for treating diseases mediated by the ALK-5 and/or ALK-4 receptor. Pharmaceutical compositions that contain the compounds and processes for preparing the compounds are also described.
摘要翻译： 游离或盐或溶剂化物形式的式I化合物，其中X，T1，T3和T4具有说明书中所示的含义，可用于治疗由ALK-5和/或ALK-4受体介导的疾病。 还描述了含有化合物的药物组合物和用于制备化合物的方法。
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公开(公告)号：US20090209552A1
公开(公告)日：2009-08-20
申请号：US12304576
申请日：2007-06-11
申请人： David Andrew Sandham , Catherine Leblanc , Claire Adcock , Kamlesh Jagdis Bala , Maude Nadine Pierrette Pipet
发明人： David Andrew Sandham , Catherine Leblanc , Claire Adcock , Kamlesh Jagdis Bala , Maude Nadine Pierrette Pipet
IPC分类号： A61K31/496 , C07D401/14
CPC分类号： C07D401/12
摘要： There are provided according to the invention compounds of formula (I) in free or salt form, wherein R3, R4, R5, R6a, R6b, Q and W are as described in the specification, process for preparing them, and their use as pharmaceuticals.
摘要翻译： 根据本发明，提供游离或盐形式的式（I）化合物，其中R3，R4，R5，R6a，R6b，Q和W如说明书中所述，其制备方法及其作为药物的用途 。
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公开(公告)号：US20090209539A1
公开(公告)日：2009-08-20
申请号：US12308232
申请日：2007-07-12
申请人： Catherine Leblanc , Maude Nadine Pierrette Pipet , Robin Alec Fairhurst , Claire Adcock , Robert Alexander Pulz , Duncan Shaw , Nikolaus Johannes Stiefl
发明人： Catherine Leblanc , Maude Nadine Pierrette Pipet , Robin Alec Fairhurst , Claire Adcock , Robert Alexander Pulz , Duncan Shaw , Nikolaus Johannes Stiefl
IPC分类号： A61K31/5377 , A61K31/497 , A61K31/506 , C07D413/14 , C07D401/14
CPC分类号： C07D401/14 , C07D405/14 , C07D413/14
摘要： Compounds of formula (I) in free or salt or solvate form, where T1, T2, Ra and Rb have the meanings as indicated in the specification, are useful for treating inflammatory or obstructive airways, pulmonary hypertension, pulmonary fibrosis, liver fibrosis, muscle diseases and systemic skeletal disorders. Pharmaceutical compositions that contain the compounds and processes for preparing the compounds are also described.
摘要翻译： 游离或盐或溶剂合物形式的式（I）化合物，其中T1，T2，Ra和Rb具有说明书中所述的含义，可用于治疗炎性或阻塞性气道，肺动脉高压，肺纤维化，肝纤维化，肌肉 疾病和系统性骨骼疾病。 还描述了含有化合物的药物组合物和用于制备化合物的方法。
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公开(公告)号：US20080312229A1
公开(公告)日：2008-12-18
申请号：US12096453
申请日：2006-12-07
IPC分类号： A61K31/437 , A61P25/00 , A61P29/00 , A61P37/00 , A61P19/00 , C07D471/04 , A61K31/5377
CPC分类号： C07D471/04
摘要： There are provided according to the invention compounds of formula (I) in free or salt form, wherein R1, R2, R4, R5, R6, A, D, X, W, m and n are as described in the specification, process for preparing them, and their use as pharmaceuticals.
摘要翻译： 根据本发明，提供游离或盐形式的式（I）化合物，其中R 1，R 2，R 4，R 5，R 6，A，D，X，W，m和n如说明书中所述， 准备他们，并用作药物。
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