公开(公告)号：US11007332B2

公开(公告)日：2021-05-18

申请号：US15844474

申请日：2017-12-15

Applicant: Impel NeuroPharma Inc.

Inventor： John D. Hoekman ,  Michael Hite ,  Alan Brunelle ,  Joel Relethford

IPC: A61M15/08 ,  A61M15/00 ,  A61M16/12 ,  B05B7/08 ,  B05B1/14 ,  A61M16/20

Abstract: A nozzle for use in delivering a mixture of aerosol propellant and drug formulation. The nozzle includes a drug product inlet configured to receive a mixture of aerosolized propellant and an intranasal dosage form. The inlet is disposed at the proximal end. A nozzle body is secured to the drug product inlet. Two or more channels are disposed within the body. Two or more orifice apertures are disposed at the distal end of the nozzle.

公开(公告)号：US10940278B2

公开(公告)日：2021-03-09

申请号：US15890266

申请日：2018-02-06

Applicant: IMPEL NEUROPHARMA, INC.

Inventor： John D. Hoekman ,  Michael Hite ,  Alan Brunelle ,  Joel Relethford

IPC: A61M15/08 ,  A61M15/00 ,  A61M16/12 ,  B05B7/08 ,  B05B1/14 ,  A61M16/20

Abstract: A nozzle for use in delivering a mixture of aerosol propellant and drug formulation. The nozzle includes a drug product inlet configured to receive a mixture of aerosolized propellant and an intranasal dosage form. The inlet is disposed at the proximal end. A nozzle body is secured to the drug product inlet. Two or more channels are disposed within the body. Two or more orifice apertures are disposed at the distal end of the nozzle.

公开(公告)号：US10537692B2

公开(公告)日：2020-01-21

申请号：US14787455

申请日：2014-04-28

Applicant: Impel NeuroPharma Inc.

Inventor： John D. Hoekman ,  Alan Brunelle ,  Craig Kohring ,  Christopher Fuller

IPC: A61M15/00 ,  A61M11/00 ,  A61M15/08 ,  A61M11/02

Abstract: A unit dose container for the containment of an intranasal formulation for use with the POD device.

公开(公告)号：US20180126101A1

公开(公告)日：2018-05-10

申请号：US15844474

申请日：2017-12-15

Applicant: Impel NeuroPharma Inc.

Inventor： John D. Hoekman ,  Michael Hite ,  Alan Brunelle ,  Joel Relethford

IPC: A61M15/08 ,  B05B1/14 ,  A61M16/12 ,  A61M15/00

CPC classification number: A61M15/08 ,  A61M15/0021 ,  A61M16/127 ,  A61M16/208 ,  A61M2202/064 ,  A61M2210/0612 ,  A61M2210/0618 ,  A61M2210/1067 ,  A61M2210/1475 ,  B05B1/14 ,  B05B7/08

Abstract: A nozzle for use in delivering a mixture of aerosol propellant and drug formulation. The nozzle includes a drug product inlet configured to receive a mixture of aerosolized propellant and an intranasal dosage form. The inlet is disposed at the proximal end. A nozzle body is secured to the drug product inlet. Two or more channels are disposed within the body. Two or more orifice apertures are disposed at the distal end of the nozzle.

公开(公告)号：US20140014104A1

公开(公告)日：2014-01-16

申请号：US14017048

申请日：2013-09-03

Applicant: Impel NeuroPharma Inc.

Inventor： John D. Hoekman ,  Michael Hite ,  Alan Brunelle ,  Joel Relethford ,  Rodney J.Y. Ho

IPC: A61M15/08

CPC classification number: A61M15/08 ,  A61M11/02 ,  A61M2202/0468 ,  A61M2202/064 ,  A61M2205/073 ,  A61M2205/8225

Abstract: A compound delivery device for delivering a plume derived from a propellant and a drug formulation. The drug formulation is in an intranasal dosage form in the form of powder, suspension, dispersion or liquid. The propelled intranasal dosage form is deposited within the olfactory region of the nasal cavity. The drug deposited within the olfactory region is delivered to the brain avoiding the blood-brain-barrier. Hydrofluoroalkane propellant from a pressurized canister is channeled to a diffuser and drug-containing chamber where the intra-nasal dosage form is aerosolized. The aerosolized intra-nasal dosage form passes through a nozzle thus delivering a plume to the olfactory region of a user's nasal cavity.

Abstract translation: 一种用于输送衍生自推进剂和药物制剂的羽流的复合递送装置。 药物制剂是以粉末，悬浮液，分散体或液体的形式的鼻内剂型。 推进的鼻内剂型沉积在鼻腔的嗅觉区域内。 沉积在嗅觉区域内的药物被输送到大脑，避免了血脑屏障。 来自加压罐的氢氟烷烃推进剂被引导到扩散器和含药物的腔室，其中鼻内剂型被雾化。 雾化的鼻内剂型通过喷嘴，从而将羽流输送到使用者鼻腔的嗅觉区域。