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公开(公告)号：US20160367981A1
公开(公告)日：2016-12-22
申请号：US15173894
申请日：2016-06-06
Applicant: IntegenX Inc.
Inventor： Philip Justus Wunderle , Chungsoo Charles Park , David King , Dennis Lehto
CPC classification number: C12Q1/6874 , B01F13/0059 , B01F13/02 , B01L3/502738 , B01L3/502753 , B01L7/52 , B01L2200/04 , B01L2200/0668 , B01L2200/16 , B01L2300/0816 , B01L2300/0887 , B01L2300/123 , B01L2400/043 , B01L2400/0478 , B01L2400/0655 , C12Q1/686 , F16K99/0015 , F16K99/0034 , F16K2099/0078 , F16K2099/0084
Abstract: This disclosure provides, among other things, a cartridge comprising: (a) a cartridge body comprising a malleable material and having, disposed on a surface of the body, at least one valve body comprising a valve inlet and a valve outlet, each fluidically connected to a fluidic channel; and (b) a layer comprising a deformable material bonded to a surface of the cartridge body and sealing the at least one valve body at points of attachment, thereby forming at least one valve; wherein the at least one valve body is depressed in the cartridge body relative to the points of attachment and wherein the deformable material covering the at least one valve body retains sufficient elasticity after deformation such that in a ground state the valve is open. Also disclosed is an instrument comprising a cartridge interface and a cartridge as described herein engaged with the cartridge interface, wherein (II) the cartridge interface comprises: (A) at least one mechanical actuator, each mechanical actuator positioned to actuate a valve; and (B) at least one motor operatively coupled to actuate a mechanical actuator toward or away from a valve.
Abstract translation: 本公开尤其提供了一种盒，其包括：（a）包括可延展材料的盒体，并且具有设置在主体表面上的至少一个阀体，其包括阀入口和阀出口，每个阀体流体连接 到流体通道; 和（b）包含结合到所述盒体表面的可变形材料并且在附接点处密封所述至少一个阀体从而形成至少一个阀的层; 其中所述至少一个阀体相对于所述连接点在所述盒体中被压下，并且其中覆盖所述至少一个阀体的所述可变形材料在变形之后保持足够的弹性，使得在基础状态下所述阀是打开的。 还公开了一种包括如本文所述的盒接口和与盒接口接合的盒的仪器，其中（II）盒接口包括：（A）至少一个机械致动器，每个机械致动器被定位成致动阀; 和（B）至少一个电动机，其可操作地联接以朝向或远离阀致动机械致动器。
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公开(公告)号：US12099032B2
公开(公告)日：2024-09-24
申请号：US16871797
申请日：2020-05-11
Applicant: IntegenX Inc.
Inventor： Alexander Kindwall , Chungsoo Charles Park , Fedor IIkov , Stevan Jovanovich , David King , Tristan Robert Littlehale , David Grant Nilson , Rick Pittaro , Robert A. Schueren , Mattias Vangbo , Philip Justus Wunderle
IPC: G01N27/447 , B01L3/00 , B01L7/00 , G01N27/453
CPC classification number: G01N27/44791 , B01L3/502715 , G01N27/44704 , G01N27/44786 , G01N27/453 , B01L7/52 , B01L2200/04 , B01L2200/10 , B01L2200/16 , B01L2300/0681 , B01L2300/0867 , B01L2300/1822 , B01L2300/1827 , B01L2400/0421 , G01N27/44743
Abstract: An electrophoresis cartridge can include an integrated electrophoresis assembly including an anode sub-assembly comprising an anode, a cathode sub-assembly comprising a cathode; and at least one electrophoresis capillary having a first end in fluid communication with the cathode sub-assembly and a second end in fluid communication with the anode sub-assembly. The cartridge can further include a reagent container comprising electrophoresis buffer; a fluid conduit in fluidic communication with the reagent container; a pump in fluidic communication with the fluid conduit, the pump configured to transfer the electrophoresis buffer through the fluid conduit from the reagent container to the passage of the cathode sub-assembly; and a sample inlet port and at least one sample line, wherein the sample line places the sample inlet port in fluidic communication with the first end of the electrophoresis capillary through a passage in the cathode sub-assembly.
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公开(公告)号：US20230392203A1
公开(公告)日：2023-12-07
申请号：US18312197
申请日：2023-05-04
Applicant: IntegenX, Inc.
Inventor： Philip Justus Wunderle , Chungsoo Charles Park , David King , Dennis Lehto
IPC: C12Q1/6874 , C12Q1/686 , B01L3/00 , F16K99/00
CPC classification number: C12Q1/6874 , C12Q1/686 , B01L3/502738 , F16K99/0015 , F16K99/0034 , B01L2300/0887 , B01L2300/123 , B01L2400/0655 , B01L3/502753 , B01L7/52
Abstract: A method of controlling fluid flow in a fluid channel of fluidic cartridge can include closing a valve by actuating a mechanical actuator against the valve to force a deformable layer against walls of a valve body, wherein the valve body comprises a valve inlet and a valve outlet and each of the valve inlet and valve outlet are fluidically coupled to a fluidic channel; releasing the valve by retracting the mechanical actuator away from the valve body; and moving liquid through the valve by applying positive or negative pressure to the fluidic channel.
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公开(公告)号：US11649496B2
公开(公告)日：2023-05-16
申请号：US16983796
申请日：2020-08-03
Applicant: IntegenX, Inc.
Inventor： Philip Justus Wunderle , Chungsoo Charles Park , David King , Dennis Lehto
CPC classification number: C12Q1/6874 , B01L3/502738 , C12Q1/686 , F16K99/0015 , F16K99/0034 , B01F33/30 , B01F33/40 , B01L3/502753 , B01L7/52 , B01L2200/04 , B01L2200/0668 , B01L2200/16 , B01L2300/0816 , B01L2300/0887 , B01L2300/123 , B01L2400/043 , B01L2400/0478 , B01L2400/0655 , F16K2099/0078 , F16K2099/0084
Abstract: A method of making an article bonding a layer of deformable material to a surface of a cartridge body having at least one valve body thereon to seal the at least one valve body, the valve body comprising a valve floor and valve walls comprising upper parts, wherein the valve floor is recessed from the surface and the valve walls extend from the surface to the valve floor, and wherein the valve body comprises walls that are curved or sloped in a direction that is non-normal to the plane defined by the surface; and deforming the layer such that upon release of a force causing the deformation, the layer is in contact with the upper parts of the valve walls and is in spaced from the valve floor so as to bias the valve to an open state.
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Patent Agency Ranking
公开(公告)号：US20190233888A1
公开(公告)日：2019-08-01
申请号：US16264389
申请日：2019-01-31
Applicant: IntegenX, Inc.
Inventor： Philip Justus Wunderle , Chungsoo Charles Park , David King , Dennis Lehto
IPC: C12Q1/6874 , C12Q1/686 , F16K99/00 , B01L3/00
CPC classification number: C12Q1/6874 , B01F13/0059 , B01F13/02 , B01L3/502738 , B01L3/502753 , B01L7/52 , B01L2200/04 , B01L2200/0668 , B01L2200/16 , B01L2300/0816 , B01L2300/0887 , B01L2300/123 , B01L2400/043 , B01L2400/0478 , B01L2400/0655 , C12Q1/686 , F16K99/0015 , F16K99/0034 , F16K2099/0078 , F16K2099/0084
Abstract: This disclosure provides, among other things, a cartridge comprising: (a) a cartridge body comprising a malleable material and having, disposed on a surface of the body, at least one valve body comprising a valve inlet and a valve outlet, each fluidically connected to a fluidic channel; and (b) a layer comprising a deformable material bonded to a surface of the cartridge body and sealing the at least one valve body at points of attachment, thereby forming at least one valve; wherein the at least one valve body is depressed in the cartridge body relative to the points of attachment and wherein the deformable material covering the at least one valve body retains sufficient elasticity after deformation such that in a ground state the valve is open. Also disclosed is an instrument comprising a cartridge interface and a cartridge as described herein engaged with the cartridge interface, wherein (II) the cartridge interface comprises: (A) at least one mechanical actuator, each mechanical actuator positioned to actuate a valve; and (B) at least one motor operatively coupled to actuate a mechanical actuator toward or away from a valve.
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公开(公告)号：US20240418675A1
公开(公告)日：2024-12-19
申请号：US18814847
申请日：2024-08-26
Applicant: IntegenX, Inc.
Inventor： Alexander Kindwall , Chungsoo Charles Park , Fedor Ilkov , Stevan Jovanovich , David King , Tristan Robert Littlehale , David Grant Nilson , Rick Pittaro , Robert A. Schueren , Mattias Vangbo , Philip Justus Wunderle
IPC: G01N27/447 , B01L3/00 , B01L7/00 , G01N27/453
Abstract: A method includes providing a system comprising an electrophoresis cartridge interface that releasably engages with an electrophoresis cartridge that includes an anode, a cathode, and at least one electrophoresis capillary that is in fluid communication with the anode and the cathode. The method further includes receiving the electrophoresis cartridge at said electrophoresis cartridge interface and automatically establishing at least one of (i) optical communication between an optical detection assembly of the system and a portion of the at least one electrophoresis capillary, (ii) electrical communication between the system and the anode and cathode, (iii) fluidic communication between the system and the at least one electrophoresis capillary, (iv) thermal communication between the system and the electrophoresis cartridge or the at least one electrophoresis capillary; (v) electromagnetic communication between the system and the electrophoresis cartridge and (vi) magnetic communication between the system and the electrophoresis cartridge.
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公开(公告)号：US10690627B2
公开(公告)日：2020-06-23
申请号：US14919620
申请日：2015-10-21
Applicant: IntegenX Inc.
Inventor： Alexander Kindwall , Chungsoo Charles Park , Fedor Ilkov , Stevan Jovanovich , David King , Tristan Robert Littlehale , David Grant Nilson , Rick Pittaro , Robert A. Schueren , Mattias Vangbo , Philip Justus Wunderle
IPC: G01N27/447 , G01N27/453 , B01L3/00 , B01L7/00
Abstract: The present disclosure provides systems and methods for sample preparation, processing and analysis. Also provided in the present disclosure is a fully-integrated electrophoresis cartridge which has a small footprint and configured to removably engage with the system.
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公开(公告)号：US10233491B2
公开(公告)日：2019-03-19
申请号：US15173894
申请日：2016-06-06
Applicant: IntegenX Inc.
Inventor： Philip Justus Wunderle , Chungsoo Charles Park , David King , Dennis Lehto
Abstract: This disclosure provides, among other things, a cartridge comprising: (a) a cartridge body comprising a malleable material and having, disposed on a surface of the body, at least one valve body comprising a valve inlet and a valve outlet, each fluidically connected to a fluidic channel; and (b) a layer comprising a deformable material bonded to a surface of the cartridge body and sealing the at least one valve body at points of attachment, thereby forming at least one valve; wherein the at least one valve body is depressed in the cartridge body relative to the points of attachment and wherein the deformable material covering the at least one valve body retains sufficient elasticity after deformation such that in a ground state the valve is open. Also disclosed is an instrument comprising a cartridge interface and a cartridge as described herein engaged with the cartridge interface, wherein (II) the cartridge interface comprises: (A) at least one mechanical actuator, each mechanical actuator positioned to actuate a valve; and (B) at least one motor operatively coupled to actuate a mechanical actuator toward or away from a valve.
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公开(公告)号：US20160116439A1
公开(公告)日：2016-04-28
申请号：US14919620
申请日：2015-10-21
Applicant: IntegenX Inc.
Inventor： Alexander Kindwall , Chungsoo Charles Park , Fedor Ilkov , Stevan Jovanovich , David King , Tristan Robert Littlehale , David Grant Nilson , Rick Pittaro , Robert A. Schueren , Mattias Vangbo , Philip Justus Wunderle
IPC: G01N27/447 , B01L3/00 , G01N27/453
Abstract: The present disclosure provides systems and methods for sample preparation, processing and analysis. Also provided in the present disclosure is a fully-integrated electrophoresis cartridge which has a small footprint and configured to removably engage with the system.
Abstract translation: 本公开提供了用于样品制备，处理和分析的系统和方法。 本公开还提供了一种完全集成的电泳盒，其具有小的占地面积并且被配置为可移除地与系统接合。
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