公开(公告)号：US12121893B2

公开(公告)日：2024-10-22

申请号：US17739567

申请日：2022-05-09

Applicant: Weavr Health Corp.

Inventor： Brandon T. Johnson

IPC: B01L3/00 ,  A61B5/15

CPC classification number: B01L3/5023 ,  A61B5/150022 ,  A61B5/150358 ,  A61B5/150755 ,  B01L3/502753 ,  B01L3/527 ,  A61B5/150343 ,  B01L2200/0605 ,  B01L2200/16 ,  B01L2300/041 ,  B01L2300/0609 ,  B01L2300/0864 ,  B01L2400/0406 ,  B01L2400/0475 ,  B01L2400/0478

Abstract: A blood sample collection and/or storage device includes a two-piece housing that encompasses a port at which a fingertip blood sample is collected. After the sample is taken, the two-piece housing is moved to a closed position to protect the sample for storage and optionally process the sample within the housing. The housing may also be opened to access the stored sample for further processing.

公开(公告)号：US20240315622A1

公开(公告)日：2024-09-26

申请号：US18680377

申请日：2024-05-31

Applicant: Magnolia Medical Technologies, Inc.

Inventor： Gregory J. BULLINGTON ,  Jay M. MIAZGA ,  Shan E. GAW ,  Timothy F. RAMSEY

IPC: A61B5/15 ,  B01L3/00

CPC classification number: A61B5/150946 ,  A61B5/15003 ,  A61B5/150099 ,  A61B5/150213 ,  A61B5/150221 ,  A61B5/150251 ,  A61B5/150992 ,  B01L3/502 ,  B01L2200/026 ,  B01L2200/027 ,  B01L2200/0684 ,  B01L2200/0689 ,  B01L2200/141 ,  B01L2300/0681 ,  B01L2300/14 ,  B01L2400/0478 ,  B01L2400/0487

Abstract: A fluid control device includes an inlet configured to be placed directly or indirectly in fluid communication with a bodily fluid source and an outlet configured to be placed in fluid communication with a fluid collection device. The fluid control device has a first state in which a negative pressure differential produced from an external source such as the fluid collection device is applied to the fluid control device to draw an initial volume of bodily fluid from the bodily fluid source, through the inlet, and into a sequestration portion of the fluid control device. The fluid control device has a second state in which (1) the sequestration portion sequesters the initial volume, and (2) the negative pressure differential draws a subsequent volume of bodily fluid, being substantially free of contaminants, from the bodily fluid source, through the fluid control device, and into the fluid collection device.

公开(公告)号：US12097027B2

公开(公告)日：2024-09-24

申请号：US15818173

申请日：2017-11-20

Applicant: Magnolia Medical Technologies, Inc.

Inventor： Gregory J. Bullington ,  Richard G. Patton ,  Shan E. Gaw ,  Jay M. Miazga ,  Jed McCann ,  Paul Goldenbaum

IPC: A61B5/15 ,  A61B5/153 ,  A61B5/154 ,  A61B5/155 ,  A61M5/162 ,  A61M5/178 ,  A61M5/48 ,  A61M39/02 ,  A61M39/22 ,  B01L3/00 ,  A61M5/32 ,  A61M25/00 ,  A61M25/06

CPC classification number: A61B5/150206 ,  A61B5/15003 ,  A61B5/150099 ,  A61B5/150221 ,  A61B5/150236 ,  A61B5/150244 ,  A61B5/150251 ,  A61B5/150351 ,  A61B5/150396 ,  A61B5/150519 ,  A61B5/150572 ,  A61B5/150732 ,  A61B5/15074 ,  A61B5/150946 ,  A61B5/153 ,  A61B5/154 ,  A61B5/155 ,  A61M5/162 ,  A61M5/178 ,  A61M5/48 ,  A61M39/0208 ,  A61M39/22 ,  B01L3/50825 ,  B01L3/563 ,  A61B5/150389 ,  A61M5/3286 ,  A61M25/005 ,  A61M25/065 ,  B01L2200/0689 ,  B01L2300/042 ,  B01L2300/044 ,  B01L2300/069 ,  B01L2300/0854 ,  B01L2400/0457 ,  B01L2400/0478 ,  B01L2400/049 ,  B01L2400/0616 ,  B01L2400/084

Abstract: A collection system configured to maintain the integrity of a bodily fluid sample has a proximal end portion, a distal end portion, and an inner surface defining a fluid flow path therethrough. The distal end portion is configured to be placed in fluid communication with a patient. The proximal end portion is configured to be placed in fluid communication with a fluid reservoir. The fluid flow path defined by the inner surface is associated with at least one flow characteristic configured to limit a stress within the flow of the bodily fluid between the distal end portion and the proximal end portion.

公开(公告)号：US12090483B2

公开(公告)日：2024-09-17

申请号：US17703570

申请日：2022-03-24

Applicant: Amazon Technologies, Inc.

Inventor： Jasmin B. Farshi ,  Pan Zhang ,  Jonathan Barry Hirst ,  Babak Ziaie ,  Bela Incze ,  Babar M. Koraishy

IPC: C12Q1/686 ,  B01L1/00 ,  B01L3/00 ,  B01L7/00 ,  G01N33/487 ,  G16H10/40 ,  G16H40/40

CPC classification number: B01L3/5029 ,  B01L1/50 ,  B01L3/5025 ,  B01L7/5255 ,  G01N33/48771 ,  G01N33/48792 ,  G16H10/40 ,  G16H40/40 ,  B01L2200/04 ,  B01L2200/0689 ,  B01L2200/082 ,  B01L2200/10 ,  B01L2200/16 ,  B01L2300/021 ,  B01L2300/027 ,  B01L2300/044 ,  B01L2300/0609 ,  B01L2300/0654 ,  B01L2300/0681 ,  B01L2300/0832 ,  B01L2300/1805 ,  B01L2300/1894 ,  B01L2400/0478 ,  C12Q1/686

Abstract: Systems, methods, and collection devices are disclosed for rapid, local PCR testing. The PCR testing system may be configured for use with a disposable sample collection device that includes a swab configured for collecting a biological sample from a patient; and a sample container configured to receive the swab and separate a bulk quantity of the biological sample from the swab for containment in a bulk collection chamber, which is located with the sample container, wherein the sample container is configured to meter a selected volume of the biological sample into a PCR sample tube, which contains a lyophilized master mix, releasably attachable to the sample container.

公开(公告)号：US12070743B2

公开(公告)日：2024-08-27

申请号：US17626385

申请日：2020-07-29

Applicant: TECAN TRADING AG

Inventor： Philipp Ott ,  Adrian Sager ,  Thomas Geiges

IPC: B01L3/02

CPC classification number: B01L3/0231 ,  B01L2200/02 ,  B01L2400/0478

Abstract: A displacement device for displacing a displacement volume is disclosed. The device has a first fluid space and a second fluid space. A first piston is arranged in a movable manner within the first fluid space. The first fluid space is connectable to a pipetting device. The first piston is actuatable by an actuation volume of air or of liquid provided by the pipetting device. A second piston is arranged in a movable manner within the second fluid space. The second piston is constructed to displace a displacement volume of a fluid located within the second fluid space when the second piston is actuated. The second piston is actuated in dependence on the first piston that is actuated by the actuation volume. The actuation volume is different from the displacement volume, and a pipetting system has a displacement device and a method of displacing a displacement volume.

公开(公告)号：US20240253047A1

公开(公告)日：2024-08-01

申请号：US18561414

申请日：2022-05-17

Applicant: Bacteromic Sp. z o.o.

Inventor： Radoslaw MILCZAREK ,  Maria ZUZGA ,  Pawel MICHALAK ,  Seweryn BAJER-BORSTYN

IPC: B01L3/00

CPC classification number: B01L3/50825 ,  B01L3/502715 ,  B01L3/502723 ,  B01L3/523 ,  B01L2200/027 ,  B01L2200/0673 ,  B01L2200/0689 ,  B01L2300/042 ,  B01L2300/047 ,  B01L2300/049 ,  B01L2400/0478 ,  B01L2400/0683

Abstract: A syringe-plug (1, 1a, 1b, 1c, 1d) for placement in a sample chamber inlet of a cartridge for analytic assays, the syringe-plug comprising a tank (2) pre-filled with a liquid, the tank (2) having a proximal end (2a) and a distal end (2b), the proximal end (2a) of the tank (2) being closed by a piston (3) movable towards said distal end (2b), the distal end (2b) of the tank (2) being closed by a pierceable membrane (6) and the piston (3) being provided on its distal end (2b) side with a rod (4) having a piercing part (5) at its end enabling to pierce the membrane (6), wherein the proximal end (2a) of the tank (2) is provided with a plug part (7) surrounding the proximal end (2a) of the tank (2), the plug part (7) comprising external sealing means in the form of: at least one retaining rib (7b) surrounding a part of the plug part (7) circumference and comprising at least one gap (8b): at least one scaling rib (7c) surrounding the whole plug part (7) circumference: a thrust flange (7d) extending to the outside of the plug part (7) by a distance larger than the retaining rib(s) (7b) and the sealing rib(s) (7c), said sealing means being arranged sequentially as seen from the distal end (2b) side of the tank (2). A cartridge (11) for analytic assays comprising a sample chamber (10, 10a) integrated with a microfluidic system (9), the microfluidic system (9) being fed with a sample of analyte (S) and with a separating liquid (L), the sample chamber (10, 10a) having an inlet (13) adapted for insertion of the sample of analyte (S), and the cartridge further comprising a syringe-plug according to the invention.

公开(公告)号：US20240228943A1

公开(公告)日：2024-07-11

申请号：US18441850

申请日：2024-02-14

Applicant: EMD Millipore Corporation

Inventor： David Dixon Newbold ,  Clinton Boyd Pepper ,  David Andrew Hansen

IPC: C12M1/00 ,  B01D27/08 ,  B01D35/26 ,  B01D61/18 ,  B01D63/00 ,  B01D63/02 ,  B01L1/00 ,  B01L3/00 ,  C12M1/12 ,  C12M1/26 ,  C12M3/00 ,  H04W74/0808 ,  H04W84/12

CPC classification number: C12M47/02 ,  B01D61/18 ,  B01D63/02 ,  B01L3/502 ,  C12M23/28 ,  C12M23/42 ,  C12M29/04 ,  C12M29/16 ,  C12M33/04 ,  C12M33/14 ,  H04W74/0808 ,  B01D27/08 ,  B01D35/26 ,  B01D63/005 ,  B01D63/028 ,  B01D2313/203 ,  B01D2313/24 ,  B01D2315/10 ,  B01L1/52 ,  B01L2300/0681 ,  B01L2300/0816 ,  B01L2400/0403 ,  B01L2400/0475 ,  B01L2400/0478 ,  C12M1/126 ,  C12M37/02 ,  H04W84/12

Abstract: A filtration system, having a filtration unit comprising a housing with a sample inlet, a sample outlet, one or more valves, a first actuator, and a second actuator and a third actuator; and a cassette adapted to fit the filtration unit, the cassette having a filter; a first reservoir in fluid communication with the filter, the first reservoir being arranged to couple to the first actuator for imparting flow to a cell-containing solution in a first direction through the filter; a second reservoir in fluid communication with the filter, the second reservoir being arranged to couple to the second actuator for imparting flow to a cell-containing solution in a second direction through said filter, wherein the second direction opposes the first direction; and a third reservoir.

公开(公告)号：US12023157B2

公开(公告)日：2024-07-02

申请号：US16891394

申请日：2020-06-03

Applicant: MANN+HUMMEL GmbH

Inventor： Dagmar Winkler ,  Heike Rupp ,  Steffen Schuetz ,  Dietmar Talmon-Gros ,  Michael Fasold ,  Alfons-Alois Schwinghammer ,  Frank Bartel ,  Sascha Bauer ,  Patrick Nytz

IPC: A61B5/15 ,  A61B5/153 ,  A61M1/02 ,  A61M1/34 ,  A61M1/36 ,  B01D39/20 ,  B01D63/02 ,  B01D65/00 ,  B01D67/00 ,  B01L3/00 ,  G01N1/40 ,  G01N33/49

CPC classification number: A61B5/150755 ,  A61B5/15003 ,  A61B5/150229 ,  A61B5/150236 ,  A61B5/150251 ,  A61M1/34 ,  A61M1/3496 ,  A61M1/36 ,  A61M1/3633 ,  B01D63/0233 ,  B01D63/028 ,  B01D63/031 ,  B01D65/00 ,  B01D67/0088 ,  G01N1/4005 ,  G01N33/491 ,  A61B5/150244 ,  A61B5/150389 ,  A61B5/150503 ,  A61B5/153 ,  A61M1/0281 ,  A61M2205/3331 ,  B01D39/2068 ,  B01D2311/02 ,  B01D2313/10 ,  B01D2313/12 ,  B01D2313/24 ,  B01D2313/901 ,  B01D2323/04 ,  B01D2323/20 ,  B01L3/502 ,  B01L2300/0681 ,  B01L2400/0478 ,  B01L2400/0481 ,  G01N2001/4016 ,  G01N2201/0221 ,  G01N2201/0222 ,  G01N2800/22

Abstract: A whole blood filtration device is provided with a filter membrane separating a feeding volume and a clean side of the filter membrane from each other. The feeding volume communicates with a first feeding side opening and with a second feeding side opening. The filter membrane has pores with a pore size that ensures permeability of the filter membrane to blood plasma/serum and that retains blood cells. The first feeding side opening can be coupled to a first blood pump for feeding blood from the first feeding side opening into the feeding volume so that blood plasma/serum permeates the filter membrane and blood cells, retained by the filter membrane, exit from the feeding volume through the second feeding side opening.

公开(公告)号：US20240175075A1

公开(公告)日：2024-05-30

申请号：US18527656

申请日：2023-12-04

Applicant: IntegenX Inc.

Inventor： David Eberhart ,  William D. Nielsen ,  Helen Franklin ,  Stevan B. Jovanovich ,  Dennis Lehto ,  Kaiwan Chear ,  James Klevenberg ,  Chungsoo Charles Park ,  Corey M. Smith ,  Philip Justus Wunderle ,  David King

IPC: C12Q1/6806 ,  B01L3/00 ,  C12Q1/686 ,  G01N27/447

CPC classification number: C12Q1/6806 ,  B01L3/502707 ,  B01L3/502715 ,  B01L3/50273 ,  B01L3/502738 ,  C12Q1/686 ,  G01N27/44743 ,  G01N27/44791 ,  B01L2200/027 ,  B01L2200/0689 ,  B01L2200/12 ,  B01L2300/041 ,  B01L2300/0654 ,  B01L2300/0681 ,  B01L2300/0848 ,  B01L2300/087 ,  B01L2300/123 ,  B01L2400/0406 ,  B01L2400/0478

Abstract: An instrument includes a fluidic cartridge having a body comprising a malleable material and a layer comprising a deformable material bonded to a surface of the body that seals one or more fluidic channels that communicate with one or more valve bodies formed in a surface of the body. The valve can be closed by applying pressure to the deformable material sufficient to close off a fluidic channel in the body. A cartridge interface is configured to engage the cartridge.

公开(公告)号：US20240116682A1

公开(公告)日：2024-04-11

申请号：US18278111

申请日：2022-03-21

Applicant: SILGAN DISPENSING SYSTEMS (WUXI) CO. LTD.

Inventor： Zhigang LI

IPC: B65D47/18 ,  A45D34/04 ,  B01L3/02 ,  B65D41/04 ,  G01F11/02

CPC classification number: B65D47/18 ,  A45D34/04 ,  B01L3/0272 ,  B65D41/0492 ,  G01F11/028 ,  A45D2200/055 ,  B01L2300/042 ,  B01L2400/0478 ,  B01L2400/0481

Abstract: The present invention relates to a cap assembly configured to be attached to a container, the cap assembly comprising: a top cap which includes a rest position and a pressable position; a piston rod connected to the top cap, the piston rod being connected to a piston at the bottom to actuate the piston to move vertically, the piston rod further comprising an inclined upper guiding surface; a deformable element bearing at the top end against the upper guiding surface of the piston rod so that the deformable element is movable along the upper guiding surface; a support which is vertically movable to move the top cap from the rest position to the pressable position, the support including an inclined lower guiding surface against which the bottom end of the deformable element is supported so that the deformable element is movable along the lower guiding surface; when the top cap is pressed, the piston rod moves downwards and actuates the piston to move downwards to dispense material from a dispensing chamber while forcing the deformable element to deform from an initial state and to move along the upper guiding surface and the lower guiding surface; and when the top cap is released, the deformable element returns to the initial state.