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    SERIAL ELECTROPHORESIS
    12.
    发明申请
    SERIAL ELECTROPHORESIS 有权

    公开(公告)号：US20250060332A1

    公开(公告)日：2025-02-20

    申请号：US18935935

    申请日：2024-11-04

    Applicant: IntegenX Inc.

    Inventor： Mattias Vangbo ,  David King ,  Arnaldo Barican

    IPC: G01N27/447 ,  C12Q1/6806 ,  C12Q1/686

    Abstract: A system for outputting electropherograms includes a capillary containing a separation medium and comprising an inlet end, a distal end, and an interrogation region between the inlet and distal ends, the inlet end of the capillary configured to receive a plurality of differing samples containing DNA fragments having a plurality of different sizes; a power source configured to selectively apply forward and reverse polarity voltages between the inlet end and the distal end of the capillary; a detector configured to detect signal associated with DNA fragments moving through the interrogation region of the capillary; and a processor communicatively coupled to the detector and configured to process signal detected by the detector and output electropherograms during an electrophoresis run, the electropherograms corresponding to a plurality of differing samples successively introduced to the capillary from the inlet and traveling through the capillary at the same time.

    Serial electrophoresis
    14.
    发明授权
    Serial electrophoresis 有权

    公开(公告)号：US12135309B2

    公开(公告)日：2024-11-05

    申请号：US18157274

    申请日：2023-01-20

    Applicant: IntegenX, Inc.

    Inventor： Mattias Vangbo ,  David King ,  Arnaldo Barican

    IPC: G01N27/447 ,  C12Q1/6806 ,  C12Q1/686

    Abstract: A system for performing capillary electrophoresis of multiple samples comprises a capillary containing a separation medium and having inlet and distal ends and an interrogation region; a power source configured to apply voltages between inlet and distal ends; and logic to cause execution of: applying a first substantially constant forward polarity electrophoresis voltage to the capillary; before all of the first DNA fragments have passed the interrogation region, applying a reverse polarity voltage pulse to the capillary, thereby transporting at least some of the first DNA fragments in the capillary toward the capillary inlet; introducing a second sample to the capillary inlet, the second sample comprising second DNA fragments having a plurality of different sizes; and applying a second substantially constant forward polarity electrophoresis voltage to the capillary to simultaneously perform electrophoresis on the second DNA fragments and the first DNA fragments.

    CONTROLLING DNA CONCENTRATION FOR STR ANALYSIS
    15.
    发明申请
    CONTROLLING DNA CONCENTRATION FOR STR ANALYSIS 有权

    公开(公告)号：US20220016632A1

    公开(公告)日：2022-01-20

    申请号：US17311263

    申请日：2019-12-04

    Applicant: Integenx, Inc.

    Inventor： Mattias Vangbo ,  David King

    IPC: B01L3/00 ,  C12Q1/6858 ,  B01L7/00

    Abstract: Performing sample quantitation and sample amplification may be performed in a sample cartridge or sample cartridges. Sample quantitation using qPCR may be performed during STR PCR on the sample. Samples need not be normalized prior to performing STR PCR. In certain embodiments, qPCR and STR PCR are performed on the same cartridge, optionally at the same time (or in real-time, or overlapping in time) and optionally using some or all of the same PCR apparatus. In other embodiments, qPCR and STR PCR are performed on different cartridges. Quantitation of the STR PCR sample may be performed without substantially delaying the STR PCR process.

    ELECTROPHEROGRAM ANALYSIS
    18.
    发明申请
    ELECTROPHEROGRAM ANALYSIS 审中-公开

    公开(公告)号：US20190353613A1

    公开(公告)日：2019-11-21

    申请号：US16315616

    申请日：2017-12-08

    Applicant: IntegenX Inc.

    Inventor： David King ,  Bruce Goldman

    IPC: G01N27/447 ,  G16B45/00

    Abstract: Methods for analyzing raw electropherogram data are disclosed. Some methods includes extracting color data as a function of time or position from the raw electropherogram darta, selecting from the electropherogram one or more peaks that contain color data for a first dye and substantially no color data from other dyes used in electrophoresis. The method also includes determining the color spectrum of the first dye, and using the color spectrum of the first dye to deconvolve the color data of the raw electropherogram data to separate the contributions of each of the dyes to the raw electropherogram data. Systems and apparatus for producing electropherograms are also disclosed.

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