公开(公告)号：US09932333B2

公开(公告)日：2018-04-03

申请号：US15326320

申请日：2015-07-15

Applicant: JAPAN SCIENCE AND TECHNOLOGY AGENCY

Inventor： Motomu Kanai ,  Yohei Soma ,  Atsuhiko Taniguchi ,  Yusuke Shimizu

IPC: C07D455/04 ,  C07D417/04

CPC classification number: C07D455/04 ,  A61K31/4725 ,  A61K31/4745 ,  A61K38/00 ,  C07D417/04 ,  C07K7/06 ,  C07K14/47

Abstract: It is intended to provide: a compound useful as an amyloid oxidation catalyst which is applicable in vivo and is applicable not only to Aβ peptides but to other amyloids; and a prophylactic or therapeutic drug for an amyloid-related disease, comprising the same. The present invention provides a benzothiazole compound represented by the following formula (1) wherein X represents a halogen atom; R1 represents an optionally substituted hydrocarbon group; R2 represents a hydrogen atom or an optionally substituted hydrocarbon group; R3 and R4 are the same or different and each represent a hydrogen atom, an optionally substituted hydrocarbon group, an alkoxy group, a halogen atom, an amino group, a nitro group, or a cyano group; R2 and R4 optionally together form an alkylene group; and R5 represents an anion.

公开(公告)号：US20180072672A1

公开(公告)日：2018-03-15

申请号：US15819180

申请日：2017-11-21

Applicant: JAPAN SCIENCE AND TECHNOLOGY AGENCY

Inventor： Yoichiro KUNINOBU ,  Motomu Kanai ,  Haruka Ida ,  Mitsumi Nishi

IPC: C07D213/53 ,  C07F15/00 ,  B01J31/22

CPC classification number: C07D213/53 ,  B01J31/1815 ,  B01J31/22 ,  B01J2231/40 ,  B01J2231/4277 ,  B01J2531/827 ,  C07F15/0033

Abstract: There are provided a compound capable of being a novel ligand allowing regioselective borylation to be performed in the aromatic borylation reaction, and a catalyst using the same compound. There is provided a bipyridyl compound represented by a general formula (1): (wherein A represents a single bond, a vinylene group or an ethynylene group;X represents an oxygen atom or a sulfur atom;n pieces of R1 may be the same or different, and R1 represents a hydrogen atom, a halogen atom, an optionally substituted hydrocarbon group, an optionally substituted alkoxy group, an optionally substituted aryloxy group, an optionally substituted amino group, a cyano group, a nitro group, or an alkoxycarbonyl group, or two adjacent R1 may form a saturated or unsaturated ring structure optionally containing a hetero atom together with the carbon atoms bonded to the two R1;R2 represents a hydrogen atom, an optionally substituted hydrocarbon group, an optionally substituted alkoxy group, or an optionally substituted aryloxy group; andn represents a number of 1 to 4).

公开(公告)号：US09908852B2

公开(公告)日：2018-03-06

申请号：US15114347

申请日：2015-01-29

Applicant: JAPAN SCIENCE AND TECHNOLOGY AGENCY

Inventor： Yoichiro Kuninobu ,  Motomu Kanai ,  Haruka Ida ,  Mitsumi Nishi

IPC: C07D213/53 ,  B01J31/22 ,  C07F15/00

CPC classification number: C07D213/53 ,  B01J31/22 ,  B01J2231/40 ,  B01J2531/827 ,  C07F15/0033

Abstract: There are provided a compound capable of being a novel ligand allowing regioselective borylation to be performed in the aromatic borylation reaction, and a catalyst using the same compound. There is provided a bipyridyl compound represented by a general formula (1): (wherein A represents a single bond, a vinylene group or an ethynylene group; X represents an oxygen atom or a sulfur atom; n pieces of R1 may be the same or different, and R1 represents a hydrogen atom, a halogen atom, an optionally substituted hydrocarbon group, an optionally substituted alkoxy group, an optionally substituted aryloxy group, an optionally substituted amino group, a cyano group, a nitro group, or an alkoxycarbonyl group, or two adjacent R1 may form a saturated or unsaturated ring structure optionally containing a hetero atom together with the carbon atoms bonded to the two R1; R2 represents a hydrogen atom, an optionally substituted hydrocarbon group, an optionally substituted alkoxy group, or an optionally substituted aryloxy group; and n represents a number of 1 to 4).

公开(公告)号：US09745349B2

公开(公告)日：2017-08-29

申请号：US14648834

申请日：2013-10-18

Applicant: JAPAN SCIENCE AND TECHNOLOGY AGENCY

Inventor： Motomu Kanai ,  Yohei Soma ,  Tadamasa Arai ,  Daisuke Sasaki ,  Yuki Kobayashi

IPC: C07K7/64 ,  A61K38/00 ,  C07K7/06

CPC classification number: C07K7/64 ,  A61K38/00 ,  C07K7/06

Abstract: A cyclic peptide or a salt thereof of formula (1): X-Leu-Val-Y1-Y2 (1), where X is Lys, Arg, His, Ala, Gly, Ser, or Thr; and Y1 and Y2, which are identical to or different from each other, each represent a group represented by formula (2): where Ar1 represents an aromatic hydrocarbon group or an aromatic heterocyclic group; R1 represents a hydrogen atom, an alkyl group, a cycloalkyl group, a haloalkyl group, an aromatic hydrocarbon group, or an aromatic heterocyclic group; and n is an integer from 0 to 2. In the cyclic peptide has an α-amino group at the amino terminus of the amino acid sequence which is linked, via a peptide bond, to the carboxyl group at the carboxyl terminus of the amino acid sequence.