公开(公告)号：US20200284946A1

公开(公告)日：2020-09-10

申请号：US16641112

申请日：2018-08-24

Applicant: JAPAN SCIENCE AND TECHNOLOGY AGENCY

Inventor： Yoichiro KUNINOBU ,  Motomu KANAI ,  Takeshi YAMAKAWA ,  Yusuke YOSHIGOE ,  Zijia WANG ,  Hideo NAGASHIMA ,  Atsushi TAHARA

IPC: G02B1/04 ,  C07D213/18 ,  C07D213/30 ,  C07D219/06 ,  C07D417/12 ,  C07D401/12 ,  C07F7/18 ,  C07F5/02

Abstract: Provided is a novel donor-acceptor type compound which emits light even in a solid state. The present invention provides an organic optical material comprising a complex formed from (1) a conjugated molecule having (a) at least one electron donating site, (b) at least one electron accepting site, and (c) at least one conjugated site in the same molecule and (2) a compound having a proton donating property or an electron pair accepting property, the complex having a non-covalent interaction at the electron accepting site, wherein the complex is solid at ordinary temperature; and the organic optical material has a property of emitting light having a maximum fluorescence wavelength which causes a Stokes shift having a value corresponding to 5% or more of the value of a maximum absorption wavelength from the maximum absorption wavelength toward the long wavelength side.

公开(公告)号：US20180042948A1

公开(公告)日：2018-02-15

申请号：US15555721

申请日：2016-03-04

Applicant: JAPAN SCIENCE AND TECHNOLOGY AGENCY

Inventor： Motomu KANAI ,  Yohei SOMA ,  Yusuke SHIMIZU ,  Atsuhiko TANIGUCHI ,  Kounosuke OISAKI ,  Yoichiro KUNINOBU

IPC: A61K31/69 ,  A61K31/4725 ,  C07F5/02 ,  C07D215/06 ,  C07D207/46 ,  C07D207/456 ,  A61K31/4025 ,  C07D401/14

CPC classification number: A61K31/69 ,  A61K31/4025 ,  A61K31/4725 ,  A61K41/00 ,  C07D207/44 ,  C07D207/456 ,  C07D207/46 ,  C07D215/06 ,  C07D401/14 ,  C07D455/04 ,  C07F5/02

Abstract: Provided are a compound which is useful as an in vivo applicable, amyloid-oxygenating catalyst selective for amyloid and applicable not only to an Aβ peptide but also to other amyloids and a drug containing the compound for preventing and/or treating amyloid-related-diseases.Disclosed is a boron-dipyrrin complex represented by the following formula (1) wherein X1 and X2 are the same or different and each represent a halogenoalkyl group or a halogen atom; R1 represents a hydrogen atom, an alkyl group, or a group represented by formula (b); R2 and R6 are the same or different and each represent a hydrogen atom or a halogen atom; R3, R4, R5, and R7 are the same or different and each represent a hydrogen atom, a halogen atom, or an alkyl group; R8 represents a hydrogen atom or —(CH2)l—(Y)m—(CH2)n—Z wherein Y represents —CO—, —CONH—, or a triazole ring, Z represents a carboxyl group, a sulfonic acid group, or a —CO-peptide residue, l and n each represent an integer of 1 to 6, and m represents 0 or 1; R9 and R10 are the same or different and each represent a hydrogen atom, an alkyl group, an alkoxy group, a halogen atom, an amino group, a nitro group, or a cyano group; and R8 and R10 together optionally form an alkylene group.

公开(公告)号：US20170001960A1

公开(公告)日：2017-01-05

申请号：US15114347

申请日：2015-01-29

Applicant: JAPAN SCIENCE AND TECHNOLOGY AGENCY

Inventor： Yoichiro KUNINOBU ,  Motomu KANAI ,  Haruka IDA ,  Mitsumi NISHI

IPC: C07D213/53 ,  B01J31/22 ,  C07F15/00

CPC classification number: C07D213/53 ,  B01J31/22 ,  B01J2231/40 ,  B01J2531/827 ,  C07F15/0033

Abstract: There are provided a compound capable of being a novel ligand allowing regioselective borylation to be performed in the aromatic borylation reaction, and a catalyst using the same compound. There is provided a bipyridyl compound represented by a general formula (1): (wherein A represents a single bond, a vinylene group or an ethynylene group;X represents an oxygen atom or a sulfur atom;n pieces of R1 may be the same or different, and R1 represents a hydrogen atom, a halogen atom, an optionally substituted hydrocarbon group, an optionally substituted alkoxy group, an optionally substituted aryloxy group, an optionally substituted amino group, a cyano group, a nitro group, or an alkoxycarbonyl group, or two adjacent R1 may form a saturated or unsaturated ring structure optionally containing a hetero atom together with the carbon atoms bonded to the two R1;R2 represents a hydrogen atom, an optionally substituted hydrocarbon group, an optionally substituted alkoxy group, or an optionally substituted aryloxy group; andn represents a number of 1 to 4).

Abstract translation: 提供了能够作为在芳族硼酸化反应中进行区域选择性硼化的新配体的化合物和使用相同化合物的催化剂。 提供由通式（1）表示的联吡啶基化合物：其中A表示单键，亚乙烯基或亚乙炔基; X表示氧原子或硫原子; n个R 1可以相同 或不同，R 1表示氢原子，卤素原子，任选取代的烃基，任选取代的烷氧基，任选取代的芳氧基，任选取代的氨基，氰基，硝基或烷氧基羰基 基团或两个相邻的R 1可以形成任选地含有杂原子和与两个R 1键合的碳原子的饱和或不饱和环结构; R 2表示氢原子，任选取代的烃基，任选取代的烷氧基 ，或任选取代的芳氧基; n表示1〜4的数）。

公开(公告)号：US20200087245A1

公开(公告)日：2020-03-19

申请号：US16489563

申请日：2018-03-02

Applicant: JAPAN SCIENCE AND TECHNOLOGY AGENCY

Inventor： Hideo NAGASHIMA ,  Atsushi TAHARA ,  Ikumi KITAHARA ,  Yoichiro KUNINOBU

IPC: C07C211/55 ,  C07C255/58 ,  C07D285/14 ,  C07D265/38 ,  C07F5/02 ,  C09K11/06

Abstract: Provided are a donor-acceptor type compound having a novel structure and its use.An enamine compound represented by general formula (1) (in the formula: R1 represents an electron-withdrawing group; A represents a divalent aromatic hydrocarbon group which may contain a substituent, a divalent aromatic heterocyclic group which may contain a substituent or a divalent unsaturated aliphatic hydrocarbon group which may contain a substituent; R2 represents a hydrogen atom or a hydrocarbon group which may contain a substituent; R3 and R4 are the same or different from each other and represent an aromatic hydrocarbon group which may contain a substituent or an aromatic heterocyclic group which may contain a substituent, or R3 and R4 together form an optionally substituted bicyclic aromatic heterocyclic group containing two or more nitrogen atoms or a nitrogen atom and an oxygen atom or a sulfur atom, or a tricyclic aromatic heterocyclic group which may contain a substituent; and R2 and A, or R2 and R3 may together form a cyclic structure).

公开(公告)号：US20180072672A1

公开(公告)日：2018-03-15

申请号：US15819180

申请日：2017-11-21

Applicant: JAPAN SCIENCE AND TECHNOLOGY AGENCY

Inventor： Yoichiro KUNINOBU ,  Motomu Kanai ,  Haruka Ida ,  Mitsumi Nishi

IPC: C07D213/53 ,  C07F15/00 ,  B01J31/22

CPC classification number: C07D213/53 ,  B01J31/1815 ,  B01J31/22 ,  B01J2231/40 ,  B01J2231/4277 ,  B01J2531/827 ,  C07F15/0033

Abstract: There are provided a compound capable of being a novel ligand allowing regioselective borylation to be performed in the aromatic borylation reaction, and a catalyst using the same compound. There is provided a bipyridyl compound represented by a general formula (1): (wherein A represents a single bond, a vinylene group or an ethynylene group;X represents an oxygen atom or a sulfur atom;n pieces of R1 may be the same or different, and R1 represents a hydrogen atom, a halogen atom, an optionally substituted hydrocarbon group, an optionally substituted alkoxy group, an optionally substituted aryloxy group, an optionally substituted amino group, a cyano group, a nitro group, or an alkoxycarbonyl group, or two adjacent R1 may form a saturated or unsaturated ring structure optionally containing a hetero atom together with the carbon atoms bonded to the two R1;R2 represents a hydrogen atom, an optionally substituted hydrocarbon group, an optionally substituted alkoxy group, or an optionally substituted aryloxy group; andn represents a number of 1 to 4).