公开(公告)号：US10087243B2

公开(公告)日：2018-10-02

申请号：US15584235

申请日：2017-05-02

Applicant: New York University ,  Janssen Biotech, Inc.

Inventor： Victor J. Torres ,  Randall J. Brezski ,  Anthony Lynch ,  William Strohl ,  Brian Whitaker ,  Mark Chiu ,  Peter T. Buckley ,  Keri Dorn ,  Michelle Kinder

IPC: C07K19/00 ,  C07K16/12 ,  C07K14/78

Abstract: The present application generally relates to multi-specific molecules that bind to multiple bacterial virulence factors, methods for producing these binding molecules, and the use of these binding molecules to treat bacterial infections. In particular, the binding molecules comprise at least two binding domains, preferably an antibody or antibody fragment and an alternative scaffold. The first binding domain is capable of binding to a glycosylated staphylococcal surface protein, preferably an SDR-containing protein. The second binding domain is capable of binding to a staphylococcal leukotoxin, preferably LukAB, LukD or LukE. These multi-specific binding compounds have killing activity against staphylococci and, thus, can be used in the treatment and/or amelioration of a Staphylococcus infection, including methicillin-resistant Staphylococcus aureus.

公开(公告)号：US09644023B2

公开(公告)日：2017-05-09

申请号：US14565069

申请日：2014-12-09

Applicant: New York University ,  Janssen Biotech, Inc.

Inventor： Victor J. Torres ,  Randall J. Brezski ,  Anthony Lynch ,  William Strohl ,  Brian Whitaker ,  Mark Chiu ,  Peter T. Buckley ,  Keri Dorn ,  Michelle Kinder

IPC: C07K19/00 ,  C07K16/12 ,  G01N33/569

CPC classification number: C07K16/1271 ,  C07K14/78 ,  C07K2317/30 ,  C07K2317/31 ,  C07K2317/51 ,  C07K2317/515 ,  C07K2318/00 ,  C07K2319/70 ,  G01N33/56938 ,  G01N2469/10

Abstract: The present application generally relates to multi-specific molecules that bind to multiple bacterial virulence factors, methods for producing these binding molecules, and the use of these binding molecules to treat bacterial infections. In particular, the binding molecules comprise at least two binding domains, preferably an antibody or antibody fragment and an alternative scaffold. The first binding domain is capable of binding to a glycosylated staphylococcal surface protein, preferably an SDR-containing protein. The second binding domain is capable of binding to a staphylococcal leukotoxin, preferably LukAB, LukD or LukE. These multi-specific binding compounds have killing activity against staphylococci and, thus, can be used in the treatment and/or amelioration of a Staphylococcus infection, including methicillin-resistant Staphylococcus aureus.

公开(公告)号：US10053513B2

公开(公告)日：2018-08-21

申请号：US14818864

申请日：2015-08-05

Applicant: Janssen Biotech, Inc.

Inventor： Stephen McCarthy ,  Bernard Scallon ,  Susan Tam ,  William Strohl ,  Omid Vafa

IPC: C07K16/32 ,  C07K16/00 ,  C07K16/28 ,  A61K39/00

CPC classification number: C07K16/32 ,  A61K2039/505 ,  C07K16/00 ,  C07K16/2887 ,  C07K2317/52 ,  C07K2317/524 ,  C07K2317/54 ,  C07K2317/70 ,  C07K2317/71 ,  C07K2317/73 ,  C07K2317/732 ,  C07K2317/734 ,  C07K2317/75 ,  C07K2317/92

Abstract: Antibody and other Fc-containing molecules with variations in the Fc region with reduced binding to Fc gamma receptors and resulting activity and can be used in the treatment of various diseases and disorders.

公开(公告)号：US09637549B2

公开(公告)日：2017-05-02

申请号：US14597690

申请日：2015-01-15

Applicant: Janssen Biotech, Inc.

Inventor： William Strohl ,  Omid Vafa

IPC: C07K16/32 ,  C07K16/00 ,  C07K16/28 ,  A61K38/00 ,  A61K39/00

CPC classification number: C07K16/32 ,  A61K38/00 ,  A61K2039/505 ,  C07K16/00 ,  C07K16/2887 ,  C07K2317/52 ,  C07K2317/524 ,  C07K2317/54 ,  C07K2317/71 ,  C07K2317/73 ,  C07K2317/732 ,  C07K2317/734 ,  C07K2317/92

Abstract: Antibody and other Fc-containing molecules with variations in the Fc region reduce binding to Fc gamma receptors and resulting activity and can be used in the treatment of various diseases and disorders.

公开(公告)号：US20150337053A1

公开(公告)日：2015-11-26

申请号：US14818864

申请日：2015-08-05

Applicant: Janssen Biotech, Inc.

Inventor： Stephen McCarthy ,  Bernard Scallon ,  Susan Tam ,  William Strohl ,  Omid Vafa

IPC: C07K16/32 ,  C07K16/28

CPC classification number: C07K16/32 ,  A61K2039/505 ,  C07K16/00 ,  C07K16/2887 ,  C07K2317/52 ,  C07K2317/524 ,  C07K2317/54 ,  C07K2317/70 ,  C07K2317/71 ,  C07K2317/73 ,  C07K2317/732 ,  C07K2317/734 ,  C07K2317/75 ,  C07K2317/92

Abstract: Antibody and other Fc-containing molecules with variations in the Fc region with reduced binding to Fc gamma receptors and resulting activity and can be used in the treatment of various diseases and disorders.

Abstract translation: 抗体和其他具有Fc区变化的含Fc分子，其与Fcγ受体的结合降低并导致活性，并可用于治疗各种疾病和病症。