摘要:
In various aspects, the invention provides molecular systems for storing and retrieving information. In some embodiments, polymers capable of selectively binding metal ions, such as nucleic acids, are used to record information in the form of a particular molecular conformation. Electrochemical assay methods employing nanopores may be used to read and write information using such polymeric media. In some embodiments, information may be recorded in a nucleic acid polymer by magnetically modulating the translocation of the nucleic acid through a channel in a medium, while simultaneously modulating the electrostatic potential across the channel. In this way, the incorporation of a divalent metal ion in the nucleic acid duplex may be modulated to store information. In an alternative aspect, the invention provides analogous processes for detecting a base pair mismatch in a nucleic acid polymer.
摘要:
In one aspect, the invention provides methods and apparatus for detecting a protein binding to a nucleic acid by measuring the impedence of a nucleic acid layer on an electrode, for example by AC impedance spectroscopy. In one embodiment, such methods may for example be used to detect a mismatch in a nucleic acid duplex.
摘要:
The invention provides systems having an electron transfer moiety tethered to an electrode by a conductive spacer moiety. A biasing potential applied to the electrode reduces the electron transfer moiety to form a reduced electron transfer species capable of absorbing a photon, to form an excited electron transfer species. An electron accepting moiety accepts an electron from the excited electron transfer species, to form a reduced electron acceptor. The reduced electron acceptor may for example be used in hydrogen generation reactions.
摘要:
In one aspect, the invention provides methods and apparatus for detecting a mismatch in a nucleic acid duplex by measuring the impedance of a nucleic acid layer on an electrode, for example by AC impedance spectroscopy.