公开(公告)号：US20090149493A1

公开(公告)日：2009-06-11

申请号：US12293545

申请日：2007-03-19

申请人： Jean Fernand Armand Lacrampe ,  Christophe Meyer ,  Bruno Schoentjes ,  Delphine Yvonne Raymonde Lardeau ,  Alain Philippe Poncelet ,  Luc Van Hijfte

发明人： Jean Fernand Armand Lacrampe ,  Christophe Meyer ,  Bruno Schoentjes ,  Delphine Yvonne Raymonde Lardeau ,  Alain Philippe Poncelet ,  Luc Van Hijfte

IPC分类号： A61K31/4439 ,  C07D405/12 ,  C07D471/04 ,  C07D401/12 ,  A61P35/00 ,  C07D495/04 ,  A61K31/443 ,  A61K31/437

CPC分类号： C07D405/12 ,  C07D401/12 ,  C07D471/04

摘要： The present invention provides compounds of formula (I), their use as an inhibitor of a p53-MDM2 interaction as well as pharmaceutical compositions comprising said compounds of formula (I) wherein n, m, p, s, t, R1, R2, A and Z have defined meanings.

摘要翻译： 本发明提供式（I）化合物，其作为p53-MDM2相互作用的抑制剂的用途以及包含所述式（I）化合物的药物组合物，其中n，m，p，s，t，R 1，R 2， A和Z定义含义。

公开(公告)号：US07241777B2

公开(公告)日：2007-07-10

申请号：US10508185

申请日：2003-03-18

申请人： Patrick René Angibaud ,  Marc Gaston Venet ,  Christophe Meyer ,  Henry Joseph Breslin

发明人： Patrick René Angibaud ,  Marc Gaston Venet ,  Christophe Meyer ,  Henry Joseph Breslin

IPC分类号： A01N43/42 ,  A61K31/47 ,  C07D215/00 ,  A61K31/498 ,  C07D43/02

CPC分类号： C07D401/06 ,  C07D401/14 ,  C07D471/04

摘要： This invention comprises the novel compounds of formula (I) wherein r, t, Y1, Y2, R1, R2, R3, R5, R6and R7 have defined meanings, having farnesyl transferase inhibiting activity; their preparation, compositions containing them and their use as a medicine.

摘要翻译： 本发明包括式（I）的新化合物，其中r，t，Y 1，Y 2，R 1，R 2， 2，R 3，R 5，R 6和R 7具有定义的含义，具有 法呢基转移酶抑制活性; 其制剂，含有它们的组合物及其作为药物的用途。

公开(公告)号：US20190142388A1

公开(公告)日：2019-05-16

申请号：US16192620

申请日：2018-11-15

申请人： Brenda Gonyeau ,  Karl Thiele ,  Nathan Silberman ,  Christophe Meyer

发明人： Brenda Gonyeau ,  Karl Thiele ,  Nathan Silberman ,  Christophe Meyer

IPC分类号： A61B8/08 ,  G16H30/40 ,  A61B8/00

摘要： Aspects of the technology described herein relate to configuring an ultrasound device with ultrasound imaging presets. Some embodiments include configuring an ultrasound device with different sets of imaging parameter values without receiving user input regarding configuration of the ultrasound device between configuration of the ultrasound device with one set of imaging parameter values and configuration of the ultrasound device with another set of imaging parameter values. Some embodiments include automatically configuring an ultrasound device with a set of imaging parameter values based on automatically determining an anatomical location being imaged by the ultrasound device. Some embodiments include automatically configuring an ultrasound device with a cardiac preset when a cardiac region is being imaged and automatically configuring the ultrasound device with an abdominal preset when an abdominal region is being imaged during a FAST or eFAST exam.

公开(公告)号：US08404713B2

公开(公告)日：2013-03-26

申请号：US12681790

申请日：2008-10-22

申请人： Patrick René Angibaud ,  Laurence Françoise Bernadette Marconnet-Decrane ,  Jorge Eduardo Vialard ,  Laurence Anne Mevellec ,  Christophe Meyer ,  Pierre-Henri Storck

发明人： Patrick René Angibaud ,  Laurence Françoise Bernadette Marconnet-Decrane ,  Jorge Eduardo Vialard ,  Laurence Anne Mevellec ,  Christophe Meyer ,  Pierre-Henri Storck

IPC分类号： A61K31/04 ,  C07D215/38

CPC分类号： C07D215/227 ,  C07D401/06 ,  C07D401/10 ,  C07D401/12 ,  C07D401/14 ,  C07D487/08

摘要： Compounds of formula (I): wherein R1, R2, R3, R4, R5, Z and n have defined meanings, the N-oxide forms, the pharmaceutically acceptable addition salts, the quaternary ammonium salts and the stereochemically isomeric forms thereof, and their use for the treatment of PARP-mediated disorders.

摘要翻译： 式（I）化合物：其中R1，R2，R3，R4，R5，Z和n具有定义的含义，N-氧化物形式，药学上可接受的加成盐，季铵盐及其立体化学异构形式，以及它们 用于治疗PARP介导的病症。

公开(公告)号：US20110028433A1

公开(公告)日：2011-02-03

申请号：US12934733

申请日：2009-03-26

申请人： Eddy Jean Edgard Freyne ,  Laurence Anne Mevellec ,  Jorge Eduardo Vialard ,  Christophe Meyer ,  Elisabeth Thérèse Jeanne Pasquier ,  Xavier Marc Bourdrez ,  Patrick René Angibaud

发明人： Eddy Jean Edgard Freyne ,  Laurence Anne Mevellec ,  Jorge Eduardo Vialard ,  Christophe Meyer ,  Elisabeth Thérèse Jeanne Pasquier ,  Xavier Marc Bourdrez ,  Patrick René Angibaud

IPC分类号： A61K31/517 ,  C07D403/06 ,  C07D239/80 ,  C07F7/10 ,  C07D401/06 ,  A61K31/695 ,  C07D417/06 ,  A61P35/00

CPC分类号： C07D239/80 ,  C07D401/06 ,  C07D417/06

摘要： The present invention provides compounds of formula (I), their use as inhibitors of tubulin polymerization as well as pharmaceutical compositions comprising said compounds of formula (I) wherein R1, R2, R3, R4, R5, R6, n, m and X have defined meanings.

摘要翻译： 本发明提供式（I）化合物，其作为微管蛋白聚合抑制剂的用途以及包含所述式（I）化合物的药物组合物，其中R1，R2，R3，R4，R5，R6，n，m和X具有 定义含义。

公开(公告)号：US20080255191A1

公开(公告)日：2008-10-16

申请号：US11758346

申请日：2007-06-05

申请人： Patrick Rene Angibaud ,  Marc Gaston Venet ,  Christophe Meyer ,  Henry Joseph Breslin

发明人： Patrick Rene Angibaud ,  Marc Gaston Venet ,  Christophe Meyer ,  Henry Joseph Breslin

IPC分类号： A61K31/4709 ,  C07D403/08 ,  A61K31/4155 ,  C07D401/08

CPC分类号： C07D401/06 ,  C07D401/14 ,  C07D471/04

摘要： This invention comprises the novel compounds of formula (I) wherein r, t, Y1, Y2, R1, R2, R3, R5, R6 and R7 have defined meanings, having farnesyl transferase inhibiting activity; their preparation, compositions containing them and their use as a medicine.

摘要翻译： 本发明包括式（I）的新化合物，其中r，t，Y 1，Y 2，R 1，R 2， 2，R 3，R 5，R 6和R 7具有定义的含义，具有 法呢基转移酶抑制活性; 其制剂，含有它们的组合物及其作为药物的用途。

公开(公告)号：US20190307428A1

公开(公告)日：2019-10-10

申请号：US16379498

申请日：2019-04-09

申请人： Nathan Silberman ,  Alex Rothberg ,  Israel Malkin ,  Karl Thiele ,  Tyler S. Ralston ,  Christophe Meyer

发明人： Nathan Silberman ,  Alex Rothberg ,  Israel Malkin ,  Karl Thiele ,  Tyler S. Ralston ,  Christophe Meyer

IPC分类号： A61B8/00 ,  A61B8/08

摘要： Aspects of the technology described herein relate to configuring an ultrasound system with imaging parameter values. In particular, certain aspects relate to configuring an ultrasound system to produce a plurality of sets of ultrasound images, each respective set of the plurality of sets of ultrasound images being produced with a different respective set of a plurality of sets of imaging parameter values; obtaining, from the ultrasound system, the plurality of sets of ultrasound images; determining a set of ultrasound images from among the plurality of sets of ultrasound images that has a highest quality; and based on determining the set of ultrasound images from among the plurality of sets of ultrasound images that has the highest quality, automatically configuring the ultrasound system to produce ultrasound images using a set of imaging parameter values with which the set of ultrasound images that has the highest quality was produced.

公开(公告)号：US08377961B2

公开(公告)日：2013-02-19

申请号：US13307153

申请日：2011-11-30

申请人： Jean Fernand Armand Lacrampe ,  Christophe Meyer ,  Bruno Schoentjes ,  Alain Philippe Poncelet ,  Camille Georges Wermuth ,  Bruno Giethlen ,  Jean-Marie Contreras ,  Muriel Joubert ,  Luc Van Hijfte

发明人： Jean Fernand Armand Lacrampe ,  Christophe Meyer ,  Bruno Schoentjes ,  Alain Philippe Poncelet ,  Camille Georges Wermuth ,  Bruno Giethlen ,  Jean-Marie Contreras ,  Muriel Joubert ,  Luc Van Hijfte

IPC分类号： A61K31/4709 ,  A61K31/4439 ,  A61K31/435 ,  C07D401/14 ,  A61P35/00

CPC分类号： C07D401/14

摘要： The present invention provides compounds of formula (I), their use as an inhibitor of a p53-MDM2 interaction as well as pharmaceutical compositions comprising said compounds of formula (I) wherein n, m, p, t, R1, R2, R3, R4, R5, R6, R7, Q, Y and Z have defined meanings.

摘要翻译： 本发明提供式（I）化合物，其作为p53-MDM2相互作用抑制剂的用途以及包含所述式（I）化合物的药物组合物，其中n，m，p，t，R 1，R 2，R 3， R4，R5，R6，R7，Q，Y和Z具有定义的含义。

公开(公告)号：US08168644B2

公开(公告)日：2012-05-01

申请号：US12934733

申请日：2009-03-26

申请人： Eddy Jean Edgard Freyne ,  Laurence Anne Mevellec ,  Jorge Eduardo Vialard ,  Christophe Meyer ,  Elisabeth Thérèse Jeanne Pasquier ,  Xavier Marc Bourdrez ,  Patrick René Angibaud

发明人： Eddy Jean Edgard Freyne ,  Laurence Anne Mevellec ,  Jorge Eduardo Vialard ,  Christophe Meyer ,  Elisabeth Thérèse Jeanne Pasquier ,  Xavier Marc Bourdrez ,  Patrick René Angibaud

IPC分类号： A01N43/54 ,  A61K31/517 ,  C07D239/72

CPC分类号： C07D239/80 ,  C07D401/06 ,  C07D417/06

摘要： The present invention provides compounds of formula (I), their use as inhibitors of tubulin polymerization as well as pharmaceutical compositions comprising said compounds of formula (I) wherein R1, R2, R3, R4, R5, R6, n, m and X have defined meanings.

摘要翻译： 本发明提供式（I）化合物，其作为微管蛋白聚合抑制剂的用途以及包含所述式（I）化合物的药物组合物，其中R1，R2，R3，R4，R5，R6，n，m和X具有 定义含义。

公开(公告)号：US20110263622A1

公开(公告)日：2011-10-27

申请号：US12934753

申请日：2009-03-26

申请人： Patrick René Angibaud ,  Laurence Anne Mevellec ,  Bruno Roux ,  Pierre-Henri Storck ,  Christophe Meyer ,  Jorge Eduardo Vialard

发明人： Patrick René Angibaud ,  Laurence Anne Mevellec ,  Bruno Roux ,  Pierre-Henri Storck ,  Christophe Meyer ,  Jorge Eduardo Vialard

IPC分类号： A61K31/506 ,  A61P35/00 ,  C07D401/10 ,  C07D221/12 ,  A61K31/473

CPC分类号： C07D401/06 ,  A61K31/4353 ,  C07D221/12

摘要： The present invention provides compounds of formula (I), their use as inhibitors of tubulin polymerization and their use as PARP inhibitors as well as pharmaceutical compositions comprising said compounds of formula (I) wherein R1, R2, R3, R4, R5, R6, R7 and Y have defined meanings.

摘要翻译： 本发明提供式（I）化合物，其作为微管蛋白聚合抑制剂及其作为PARP抑制剂的用途以及包含所述式（I）化合物的药物组合物，其中R1，R2，R3，R4，R5，R6， R7和Y定义含义。