公开(公告)号：US20120258467A1

公开(公告)日：2012-10-11

申请号：US13515678

申请日：2010-12-16

申请人： Swetha Chinnayelka ,  Paul Ripley

发明人： Swetha Chinnayelka ,  Paul Ripley

IPC分类号： G01N21/64 ,  C12M1/42 ,  G01N21/80

CPC分类号： G01N33/52 ,  A61B5/1451 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1455 ,  G01N33/542 ,  G01N33/66 ,  G01N33/92

摘要： The invention provides transdermal optical analysis systems, test sensors, methods, and kits for determining the presence and/or concentration of at least one analyte in a fluid sample. The system includes a transdermal test sensor including an aqueous material including at least one analyte selective reagent and at least one optically active moiety. The optical system preferably uses fluorescent spectroscopy to correlate fluorescent emission or adsorption from a dye with the analyte concentration of the sample. An optical light source and/or detector may be housed with the aqueous material in a housing or external to the housing of the aqueous material.

摘要翻译： 本发明提供透皮光学分析系统，测试传感器，方法和用于确定流体样品中至少一种分析物的存在和/或浓度的试剂盒。 该系统包括透皮测试传感器，其包括含有至少一种分析物选择性试剂和至少一种光学活性部分的水性材料。 光学系统优选使用荧光光谱法将染料的荧光发射或吸附与样品的分析物浓度相关联。 可将光学光源和/或检测器与含水材料一起容纳在壳体中或水性材料壳体的外部。

公开(公告)号：US20110269147A1

公开(公告)日：2011-11-03

申请号：US13054543

申请日：2009-07-20

申请人： Swetha Chinnayelka

发明人： Swetha Chinnayelka

IPC分类号： G01N21/75 ,  C12M1/34

CPC分类号： G01N33/723 ,  G01N21/6428 ,  G01N33/542 ,  G01N33/558 ,  G01N33/721 ,  G01N2333/805 ,  G01N2800/22

摘要： Methods, devices, and systems for measuring the concentration of glycated hemoglobin (HbA1c) in a blood sample are provided. A blood sample may be contacted with a lysing agent, an assay to measure total Hb, and an assay to measure HbA1c, which comprises donor and acceptor dyes attached to a Hb specific antibody and a HbA1c analog. Preferably, the emission spectrum of the donor dye overlaps with the excitation spectrum of the acceptor dye. The concentration of HbA1c in the sample may be correlated with an increase in donor dye and/or a decrease in acceptor dye fluorescence in the presence of HbA1c as compared to the donor and/or the acceptor dye fluorescence in the absence of HbA1c.

摘要翻译： 提供了用于测量血液样品中糖化血红蛋白（HbA1c）浓度的方法，装置和系统。 血液样品可以与裂解剂接触，测定总Hb的测定法和测量HbA1c的测定法，其包括连接于Hb特异性抗体和HbA1c类似物的供体和受体染料。 优选地，供体染料的发射光谱与受体染料的激发光谱重叠。 与没有HbA1c的供体和/或受体染料荧光相比，在HbA1c存在下，样品中HbA1c的浓度可能与供体染料的增加和/或受体染料荧光的降低相关。