公开(公告)号：US10287392B2

公开(公告)日：2019-05-14

申请号：US15717212

申请日：2017-09-27

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Soo Hyun Kim ,  Young Mee Jung ,  Seung Hyuk Im

IPC: C08G63/08 ,  C08G63/664 ,  G01N25/48

Abstract: Disclosed is a method for preparing a poly(L-lactic acid) composite. According to the method, PLLA can be processed without losing its physical properties during thermal processing and can be effectively used to manufacture a final product with improved thermal properties. In addition, the monomer is not thermally decomposed during high-temperature polymerization. Therefore, the poly(L-lactic acid) composite can be prevented from browning. Also disclosed is a poly(L-lactic acid) composite prepared by the method.

公开(公告)号：US20180042984A1

公开(公告)日：2018-02-15

申请号：US15556963

申请日：2016-03-14

Applicant: Samsung Life Public Welfare Foundation ,  Korea Institute of Science and Technology

Inventor： Sang Jun Kim ,  Young Mee Jung ,  Soo Hyun Kim

IPC: A61K38/08 ,  A61K9/00 ,  A61K38/16 ,  A61K35/28 ,  A61K38/10

CPC classification number: A61K38/08 ,  A61K9/0019 ,  A61K9/06 ,  A61K35/28 ,  A61K38/046 ,  A61K38/10 ,  A61K38/16 ,  A61K47/26

Abstract: The present invention relates to: a pharmaceutical composition for preventing or treating arthritis, which comprises synthetic polypeptides; injections for preventing or treating arthritis; and a pharmaceutical composition for inducing differentiation of cartilage cells. Synthetic polypeptides of the present invention consisting of a polypeptide represented by SEQ ID NO: 1 and a polypeptide represented by SEQ ID NO: 2 have activity for recruiting stem cells to an arthritis region, inhibit apoptosis of cartilage cells, and exhibit anti-inflammatory activity and activity for promoting regeneration of cartilage cells. Thus, unlike a conventional arthritis treatment agent, the synthetic polypeptides can improve cartilage damage, can inhibit degenerative changes per se and can, at the same time, exhibit an effect as a stem cell treatment agent, and thereby can be usefully utilized as an arthritis prevention or treatment agent.

公开(公告)号：US09358093B2

公开(公告)日：2016-06-07

申请号：US13713414

申请日：2012-12-13

Applicant: Korea Institute of Science and Technology

Inventor： Soo Hyun Kim ,  Jin Ik Lim ,  Youngmee Jung

IPC: A61F2/01 ,  A61L33/02

CPC classification number: A61F2/01 ,  A61L33/022 ,  A61L2400/12

Abstract: The present disclosure relates to a bioimplantable device having a superhydrophobic surface and a method for manufacturing the same. The bioimplantable device, which includes a biocompatible substrate and a superhydrophobic nanostructure formed on the surface of the biocompatible substrate, is capable of preventing blood clot formation by blocking contact with proteins, water, blood platelets, etc. when used for blood vessels.

Abstract translation: 本公开涉及具有超疏水表面的生物可​​植入装置及其制造方法。 生物可植入装置，其包括生物相容性底物和形成在生物相容性底物表面上的超疏水性纳米结构，能够通过与用于血管的蛋白质，水，血小板等阻断接触来防止血块形成。