公开(公告)号：US20050201941A1

公开(公告)日：2005-09-15

申请号：US11125990

申请日：2005-05-10

申请人： Hui-Ju Cho ,  Sheng-Ming Shih ,  Yuh-Jiuan Lin ,  Hong-Dun Lin ,  Kang-Ping Lin

发明人： Hui-Ju Cho ,  Sheng-Ming Shih ,  Yuh-Jiuan Lin ,  Hong-Dun Lin ,  Kang-Ping Lin

IPC分类号： A61K47/48 ,  A61K49/18 ,  A61K49/00

CPC分类号： B82Y5/00 ,  A61K47/6923 ,  A61K49/1818 ,  A61K49/183 ,  Y10T428/2991

摘要： A magnetic nanoparticle applicable in imaging, diagnosis, therapy and biomaterial separation. The magnetic nanoparticle is characterized as comprising at least an inner-transition element, represented as FexMavZy, wherein Ma is an inner-transition element, Z is an element of the group VIa, x is greater or equal to 0, and both v and y are positive numbers. The magnetic nanoparticle may further comprise a shell to form a core-shell structure, wherein the shell is an inner-transition element Mb or the compound thereof.

摘要翻译： 适用于成像，诊断，治疗和生物材料分离的磁性纳米颗粒。 磁性纳米颗粒的特征在于至少包含一个内部过渡元素，其表示为Fe x Z y， SUB>，其中M a A是内部过渡元素，Z是组VIa的元素，x大于或等于0，并且v和y均为正数。 磁性纳米颗粒还可以包含壳形成核 - 壳结构，其中壳是内部过渡元素M b或其化合物。

公开(公告)号：US20050154324A1

公开(公告)日：2005-07-14

申请号：US10753388

申请日：2004-01-09

申请人： Kang-Ping Lin ,  Chih-Hui Hsieh

发明人： Kang-Ping Lin ,  Chih-Hui Hsieh

IPC分类号： A61B5/04 ,  A61B5/0402 ,  A61B5/0404 ,  A61B5/0408 ,  A61B5/0464

CPC分类号： A61B5/0404 ,  A61B5/04085 ,  A61B5/0464

摘要： The present invention is in relative to a a device for measuring electrocardiogram with tapeless format and its method, especially the electrocardiogram measure device which measures electrocardiogram signals via electrodes with flat shape touching with two roots between total four fingers of two hands or electrodes embedded-in thereon only touching with two fingers for two hands, the invention can display the electrocardiogram measured directly without adding any conductive material. The present invention comprises a shell, shaped as a thin and long cube and having at least one operating panel, the operating panel further comprising at least one button for setting and transferring functions; at least two gelless electrodes with thin foil shape, slightly embedded and fixed in the operating panel and extended and surrounded at least one edge of the shell to a surface opposite to the operating panel; at least one information display, located on the operating panel to display a plurality of measured values; a calculation system, connecting with two gelless electrodes and the information display located in the shell in order to calculate relative electrical information measured from the gelless electrodes and display results on the information display.

摘要翻译： 本发明涉及一种用于无磁带格式的心电图测量装置及其方法，特别是通过具有平面形状的电极测量心电图信号的心电图测量装置，其中两根手指或两只手的电极嵌入其中， 只用两只手指触摸双手，本发明可以显示直接测量的心电图而不添加任何导电材料。 本发明包括成形为薄且长的立方体并具有至少一个操作面板的外壳，操作面板还包括用于设置和传递功能的至少一个按钮; 具有薄箔形状的至少两个不凝胶电极，稍微嵌入并固定在操作面板中，并且将壳体的至少一个边缘延伸并包围到与操作面板相对的表面; 至少一个信息显示器，位于操作面板上以显示多个测量值; 计算系统，与两个无凝胶电极连接，信息显示位于壳体中，以计算从无胶体电极测量的相对电信息，并在信息显示屏上显示结果。

公开(公告)号：US07338812B2

公开(公告)日：2008-03-04

申请号：US10600830

申请日：2003-06-23

申请人： Chin-I Lin ,  Kang-Ping Lin ,  Yuh-Jiuan Lin ,  Sheng-Ming Shih ,  K Abraham Joseph ,  Chao-Kang Chang

发明人： Chin-I Lin ,  Kang-Ping Lin ,  Yuh-Jiuan Lin ,  Sheng-Ming Shih ,  K Abraham Joseph ,  Chao-Kang Chang

IPC分类号： G01N33/544

CPC分类号： B82Y15/00 ,  G01N33/532 ,  G01N33/543 ,  G01N33/553 ,  G01N33/588

摘要： A biochemical labeling material and manufacturing method thereof. The manufacturing method provides a plurality of nanoparticles, bonding the nanoparticles to template molecules by molecular imprinting, polymerizing the nanoparticles to form a matrix with uniformly-distributed template molecules, finally removing the template molecules from the matrix to reveal a detection group of the matrix, leaving a cavity with specific area.

摘要翻译： 生物化学标签材料及其制造方法。 该制造方法提供多个纳米颗粒，通过分子印迹将纳米颗粒结合到模板分子上，聚合纳米颗粒以形成具有均匀分布的模板分子的基质，最后从基质中除去模板分子以显示基质的检测基团， 留下具有特定面积的空腔。

公开(公告)号：US20060120964A1

公开(公告)日：2006-06-08

申请号：US11336347

申请日：2006-01-20

申请人： Hui-Ju Cho ,  Sheng-Ming Shih ,  Yuh-Jiuan Lin ,  Hong-Dun Lin ,  Kang-Ping Lin

发明人： Hui-Ju Cho ,  Sheng-Ming Shih ,  Yuh-Jiuan Lin ,  Hong-Dun Lin ,  Kang-Ping Lin

IPC分类号： A61K49/16 ,  A61K49/08

CPC分类号： B82Y5/00 ,  A61K47/6923 ,  A61K47/6929 ,  A61K49/183 ,  Y10S977/777 ,  Y10S977/904 ,  Y10S977/915 ,  Y10T428/2982

摘要： Magnetic nanoparticles are applicable in imaging, diagnosis, therapy, and biomaterial separation. The magnetic nanoparticles are represented as (FewGdx)Zy, wherein w is from 99.9% to 97.5%, x is from 0.1% to 2.5%, Z is an element of the group VIa, and v, y are positive numbers.

摘要翻译： 磁性纳米颗粒适用于成像，诊断，治疗和生物材料分离。 磁性纳米颗粒表示为（Fe x Gd x Z z）Z y y，其中w为99.9％至97.5％，x为0.1 ％至2.5％，Z为VIa族的元素，v，y为正数。

公开(公告)号：US20060111638A1

公开(公告)日：2006-05-25

申请号：US11126612

申请日：2005-05-11

申请人： Hen-Hong Chang ,  Kang-Ping Lin ,  Wen-Chen Lin

发明人： Hen-Hong Chang ,  Kang-Ping Lin ,  Wen-Chen Lin

IPC分类号： A61B5/02

CPC分类号： A61B5/022 ,  A61B5/7242

摘要： The invention is related to a noninvasive pulse measurement system with constant pressure for extremities of a human, and the constant pressure is modulated among 30 to 120 mmHg. There are an auto-mode and a manual mode for measurement algorithm. The auto-mode completes measurement and recording processes automatically during 2 minutes and pressurizes the system from low pressure (30 mmHg) to high pressure (120 mmHg) with 10 mmHg gradient every 5 seconds while the manual mode completes measurement and recording processes during a long time under a user's setting. Moreover, by a post-treatment of the system, the system is able to obtain continuous pulse signals, continuous pulse differential signals, and continuous pulse integral signals that are useful for Chinese medicine to evaluate and monitor the user's cardio-physiology and circulatory system.

摘要翻译： 本发明涉及一种具有恒定压力的无创脉冲测量系统，用于人的四肢，并且将恒压调制在30至120mmHg之间。 有自动模式和手动模式的测量算法。 自动模式在2分钟内自动完成测量和记录过程，并将系统从低压（30 mmHg）压缩至高压（120 mmHg），每5秒钟以10mmHg的梯度加压，而手动模式在长时间内完成测量和记录过程 在用户设置下的时间。 此外，通过对系统进行后处理，该系统能够获得连续脉冲信号，连续脉冲差分信号和连续脉冲积分信号，这些信号对于中医药评估和监测用户的心脏生理和循环系统是有用的。

公开(公告)号：US20050274629A1

公开(公告)日：2005-12-15

申请号：US10854369

申请日：2004-05-27

申请人： Kang-Ping Lin

发明人： Kang-Ping Lin

IPC分类号： G01N27/26 ,  G01N33/543

CPC分类号： G01N33/5438

摘要： The present invention relates to offer an apparatus and a method for an integral electrochemical biosensor combining designs of blood sampling, continuous and multiply testing, multi-channel detecting and adjustable working voltage; furthermore several physiologic parameters can be obtained simultaneously in an identical testing. The invention provides convenience for users and improves the practicability. Said integral electrochemical biosensor comprises: at least a sampling device configured to supply a sample carrying room, which is in vacuum or a state of relative negative pressure by an applied force with a pressure difference to make inactive humor at a relative high pressure injecting into said sample carrying room; a plurality of electrode sets comprising a compared electrode, an assisting electrode and an operating electrode, on which chemical and/or physical reactions between said inactive humor and chemicals bring out after said inactive humor injecting into said sample carrying room; a multi-channel electrochemical detector configured to provide several choices of operating voltage for said operating electrodes; a logic and data device configured to grab and calculate data of result from said physical or/and chemical reactions; a signal displaying device configured to explicitly show physiological parameter values of said inactive humor and corresponding concentration of said physiological parameters.

摘要翻译： 本发明涉及提供一种集成电化学生物传感器的装置和方法，其结合了血液采样，连续和多次测试，多通道检测和可调工作电压的设计; 此外，可以在相同的测试中同时获得几个生理参数。 本发明为用户提供便利，提高了实用性。 所述一体式电化学生物传感器包括：至少一个采样装置，其被配置为通过施加的压力差提供处于真空状态或相对负压状态的样品携带室，以使相对高压注入所述 样品携带室; 多个电极组，包括比较电极，辅助电极和操作电极，所述无活性幽默和化学物质在所述无活性幽默注射入所述样品携带室之后引起化学和/或物理反应; 多通道电化学检测器，被配置为为所述操作电极提供几种工作电压选择; 逻辑和数据设备被配置为从所述物理或/和化学反应中获取和计算结果的数据; 信号显示装置，被配置为明确地显示所述无效幽默的生理参数值和所述生理参数的对应浓度。

公开(公告)号：US20050025971A1

公开(公告)日：2005-02-03

申请号：US10741238

申请日：2003-12-19

申请人： Hui-Ju Cho ,  Sheng-Ming Shih ,  Yuh-Jiuan Lin ,  Hong-Dun Lin ,  Kang-Ping Lin

发明人： Hui-Ju Cho ,  Sheng-Ming Shih ,  Yuh-Jiuan Lin ,  Hong-Dun Lin ,  Kang-Ping Lin

IPC分类号： A61K47/48 ,  A61K49/18 ,  B32B5/16 ,  B32B15/02 ,  B32B23/02 ,  B32B27/02

CPC分类号： B82Y5/00 ,  A61K47/6923 ,  A61K49/1818 ,  A61K49/183 ,  Y10T428/2991

摘要： A magnetic nanoparticle applicable in imaging, diagnosis, therapy and biomaterial separation. The magnetic nanoparticle is characterized as comprising at least an inner-transition element, represented as FexMavZy, wherein Ma is an inner-transition element, Z is an element of the group VIa, x is greater or equal to 0, and both v and y are positive numbers. The magnetic nanoparticle may further comprise a shell to form a core-shell structure, wherein the shell is an inner-transition element Mb or the compound thereof.

摘要翻译： 适用于成像，诊断，治疗和生物材料分离的磁性纳米颗粒。 磁性纳米颗粒的特征在于至少包含内部过渡元素，表示为FexMaAvZy，其中M是>内部过渡元素，Z是VIa的元素，x大于或等于 0，v和y均为正数。 磁性纳米颗粒还可以包含壳形成核 - 壳结构，其中壳是内部过渡元素M或其化合物。

公开(公告)号：US07471976B2

公开(公告)日：2008-12-30

申请号：US10753388

申请日：2004-01-09

申请人： Kang-Ping Lin ,  Chih-Hui Hsieh

发明人： Kang-Ping Lin ,  Chih-Hui Hsieh

IPC分类号： A61B5/0404

CPC分类号： A61B5/0404 ,  A61B5/04085 ,  A61B5/0464

摘要： A device for measuring an electrocardiogram with a tapeless format and its method is provided with electrodes having a flat shape that are contacted by root portions between two fingers of a user's hands or by two fingers of each of the user's hands. The electrocardiogram can be measured directly by that contact, without adding any conductive liquid or gel material.

摘要翻译： 用于以无带格式测量心电图的装置及其方法设置有具有平坦形状的电极，其与使用者的手的两个手指的两根手指之间的根部部分或用户的手中的每个手指接触。 心电图可以直接由该接触测量，而不添加任何导电液体或凝胶材料。

公开(公告)号：US20070166232A1

公开(公告)日：2007-07-19

申请号：US11687697

申请日：2007-03-19

申请人： Hui-Ju Cho ,  Sheng-Ming Shih ,  Yuh-Jiuan Lin ,  Hong-Dun Lin ,  Kang-Ping Lin

发明人： Hui-Ju Cho ,  Sheng-Ming Shih ,  Yuh-Jiuan Lin ,  Hong-Dun Lin ,  Kang-Ping Lin

IPC分类号： A61K49/10

CPC分类号： A61K49/183 ,  B82Y5/00 ,  Y10S977/773 ,  Y10S977/777 ,  Y10S977/904 ,  Y10T428/2991

摘要： Magnetic nanoparticles are applicable in imaging, diagnosis, therapy, and biomaterial separation. The magnetic nanoparticles comprise a core represented as FexMavZy and a shell of an inner-transition element Mb or the compound thereof, wherein Ma is an inner-transition element, Z is an element of the group Vla, x is greater or equal to 0, and v, y are positive numbers. The surface of the shell is optionally modified by liposome, polymer, aliphatic compound, aromatic compound or combinations thereof.

摘要翻译： 磁性纳米颗粒适用于成像，诊断，治疗和生物材料分离。 磁性纳米颗粒包含一个表示为Fe x Si x Z y的核， 过渡元素M b或其化合物，其中M a是内部过渡元素，Z是基团Vla的元素，x大于或等于0， v，y为正数。 壳的表面任选地被脂质体，聚合物，脂族化合物，芳族化合物或其组合改性。