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    DENDRITIC COMPOUND AND USE THEREOF
    2.
    发明申请
    DENDRITIC COMPOUND AND USE THEREOF 审中-公开
    化合物及其用途

    公开(公告)号：US20100204508A1

    公开(公告)日：2010-08-12

    申请号：US12767154

    申请日：2010-04-26

    Applicant: Abraham JOSEPHK ,  Hui-Ju CHO ,  Yu-Hau SHIH ,  Chao-Hung KAO ,  Huang-Chien LIANG

    Inventor： Abraham JOSEPHK ,  Hui-Ju CHO ,  Yu-Hau SHIH ,  Chao-Hung KAO ,  Huang-Chien LIANG

    IPC: C07C69/34

    CPC classification number: A61K49/124

    Abstract: A dendritic compound of the following structure: PDn-Z-L is disclosed. In the structure above, P is X—(CH2CH2—O)r—, r is an integer ranging from 1000 to 4000, X is OH, NH2, or OR, R is C1 to C10 alkyl, Dn is a residue of branched C3 to C30 polyol compounds, n is the quantity of layers of the residue of branched compounds and is an integer equal to or greater than 1, L is a metal cation, Z is the residue of a C3 to C30 compound with multi functional groups. The functional groups illustrated above can be carboxylic groups, amino groups, amide groups, or chelating groups. The carboxylic groups, ester groups, amino groups, or amide groups bind to Dn, and the chelating groups bind to the metal cations.

    Abstract translation: 公开了以下结构的树枝状化合物：PDn-Z-L。 在上述结构中，P是X-（CH 2 CH 2 -O）r - ，r是1000-4000的整数，X是OH，NH2或OR，R是C1-C10烷基，Dn是支链C3的残基 至C30多元醇化合物，n为支链化合物残基的层数，为1以上的整数，L为金属阳离子，Z为多官能团的C3〜C30化合物的残基。 上述官能团可以是羧基，氨基，酰胺基或螯合基。 羧基，酯基，氨基或酰胺基与Dn结合，螯合基与金属阳离子结合。

    Magnetic nanoparticle
    4.
    发明申请
    Magnetic nanoparticle 审中-公开
    磁性纳米颗粒

    公开(公告)号：US20050201941A1

    公开(公告)日：2005-09-15

    申请号：US11125990

    申请日：2005-05-10

    Applicant: Hui-Ju Cho ,  Sheng-Ming Shih ,  Yuh-Jiuan Lin ,  Hong-Dun Lin ,  Kang-Ping Lin

    Inventor： Hui-Ju Cho ,  Sheng-Ming Shih ,  Yuh-Jiuan Lin ,  Hong-Dun Lin ,  Kang-Ping Lin

    IPC: A61K47/48 ,  A61K49/18 ,  A61K49/00

    CPC classification number: B82Y5/00 ,  A61K47/6923 ,  A61K49/1818 ,  A61K49/183 ,  Y10T428/2991

    Abstract: A magnetic nanoparticle applicable in imaging, diagnosis, therapy and biomaterial separation. The magnetic nanoparticle is characterized as comprising at least an inner-transition element, represented as FexMavZy, wherein Ma is an inner-transition element, Z is an element of the group VIa, x is greater or equal to 0, and both v and y are positive numbers. The magnetic nanoparticle may further comprise a shell to form a core-shell structure, wherein the shell is an inner-transition element Mb or the compound thereof.

    Abstract translation: 适用于成像，诊断，治疗和生物材料分离的磁性纳米颗粒。 磁性纳米颗粒的特征在于至少包含一个内部过渡元素，其表示为Fe x Z y， SUB>，其中M a A是内部过渡元素，Z是组VIa的元素，x大于或等于0，并且v和y均为正数。 磁性纳米颗粒还可以包含壳形成核 - 壳结构，其中壳是内部过渡元素M b或其化合物。

    MAGNETIC NANOPARTICLES
    5.
    发明申请
    MAGNETIC NANOPARTICLES 有权
    磁性纳米粒子

    公开(公告)号：US20070166232A1

    公开(公告)日：2007-07-19

    申请号：US11687697

    申请日：2007-03-19

    Applicant: Hui-Ju Cho ,  Sheng-Ming Shih ,  Yuh-Jiuan Lin ,  Hong-Dun Lin ,  Kang-Ping Lin

    Inventor： Hui-Ju Cho ,  Sheng-Ming Shih ,  Yuh-Jiuan Lin ,  Hong-Dun Lin ,  Kang-Ping Lin

    IPC: A61K49/10

    CPC classification number: A61K49/183 ,  B82Y5/00 ,  Y10S977/773 ,  Y10S977/777 ,  Y10S977/904 ,  Y10T428/2991

    Abstract: Magnetic nanoparticles are applicable in imaging, diagnosis, therapy, and biomaterial separation. The magnetic nanoparticles comprise a core represented as FexMavZy and a shell of an inner-transition element Mb or the compound thereof, wherein Ma is an inner-transition element, Z is an element of the group Vla, x is greater or equal to 0, and v, y are positive numbers. The surface of the shell is optionally modified by liposome, polymer, aliphatic compound, aromatic compound or combinations thereof.

    Abstract translation: 磁性纳米颗粒适用于成像，诊断，治疗和生物材料分离。 磁性纳米颗粒包含一个表示为Fe x Si x Z y的核， 过渡元素M b或其化合物，其中M a是内部过渡元素，Z是基团Vla的元素，x大于或等于0， v，y为正数。 壳的表面任选地被脂质体，聚合物，脂族化合物，芳族化合物或其组合改性。

    Analytical method and device utilizing magnetic materials
    6.
    发明申请
    Analytical method and device utilizing magnetic materials 失效
    利用磁性材料的分析方法和装置

    公开(公告)号：US20060286563A1

    公开(公告)日：2006-12-21

    申请号：US11320659

    申请日：2005-12-30

    Applicant: Yuh-Jiuan Lin ,  Kun-Feng Lee ,  Chi-Min Chau ,  Hui-Ju Cho

    Inventor： Yuh-Jiuan Lin ,  Kun-Feng Lee ,  Chi-Min Chau ,  Hui-Ju Cho

    IPC: C12Q1/68 ,  C12M1/34 ,  G01N33/553

    CPC classification number: G01N33/54326 ,  G01N33/54373 ,  Y10S436/805

    Abstract: The present invention relates to an analytical method and device utilizing magnetic materials and acoustics sensor. The invention employs a magnetic material modified with specific recognizable molecules to capture a substance in a sample and provides an external magnetic field to draw the magnetic material to an sensing region of an acoustics sensor, and then converts an effect occurred on a surface of the sensing region to an amount of the substance in the sample, wherein the effect is caused by a contact of the surface with the magnetic material and the substance.

    Abstract translation: 本发明涉及利用磁性材料和声学传感器的分析方法和装置。 本发明采用用特定可识别分子修饰的磁性材料来捕获样品中的物质，并提供外部磁场以将磁性材料吸引到声学传感器的感测区域，然后转换在感测表面上发生的影响 区域相对于样品中物质的量，其中效果是由表面与磁性材料和物质的接触引起的。

    REAGENT, CHAOTROPIC AGENT, AND REAGENT KIT FOR AND APPLICATIONS OF ISOLATING NUCLEIC ACID BY USE OF MAGNETIC CELLULOSE MATERIAL
    7.
    发明申请
    REAGENT, CHAOTROPIC AGENT, AND REAGENT KIT FOR AND APPLICATIONS OF ISOLATING NUCLEIC ACID BY USE OF MAGNETIC CELLULOSE MATERIAL 有权
    通过使用磁性纤维素材料分离核酸的试剂，化学试剂和试剂盒和应用

    公开(公告)号：US20110166338A1

    公开(公告)日：2011-07-07

    申请号：US12935681

    申请日：2008-04-02

    Applicant: Pei-Shin Jiang ,  Yu-Ting Su ,  Kun-Chan Wu ,  Hui-Ju Cho ,  Wen-Hsun Kuo ,  Yuh-Jiuan Lin ,  Yi-Ling Li ,  Cheng-Chun Kuan

    Inventor： Pei-Shin Jiang ,  Yu-Ting Su ,  Kun-Chan Wu ,  Hui-Ju Cho ,  Wen-Hsun Kuo ,  Yuh-Jiuan Lin ,  Yi-Ling Li ,  Cheng-Chun Kuan

    IPC: C07H1/06 ,  C07H1/08 ,  H01F1/42

    CPC classification number: C07H1/06 ,  C07H21/00 ,  C12N15/1013

    Abstract: Disclosed are a chaotropic agent; a reagent including a chaotropic agent and a lithium salt; a reagent kit including a chaotropic agent; a chaotropic agent, a reagent, a reagent kit, and a method for isolating a nucleic acid by use of a magnetic cellulose material; a method for binding a nucleic acid to a magnetic cellulose material; a method for isolating a nucleic acid; and a method for purifying a chromosome DNA. It is required that each of the chaotropic agents, the reagents, and the reagent kits works with at least one solid-phase, magnetic cellulose-containing carrier to isolate a nucleic acid from non-nucleic acid substances. In addition, each chaotropic agent includes an alcohol substance and a substrate solution for adjusting the alcohol substance to an appropriate concentration and thereby promoting binding of the nucleic acid in a sample to the magnetic cellulose.

    Abstract translation: 公开了一种离液剂; 包含离液剂和锂盐的试剂; 包含离液剂的试剂盒; 离液剂，试剂，试剂盒和通过使用磁性纤维素材料分离核酸的方法; 将核酸与磁性纤维素材料结合的方法; 分离核酸的方法; 以及纯化染色体DNA的方法。 需要每种离液剂，试剂和试剂盒与至少一种固相含磁性纤维素的载体一起工作，以将核酸与非核酸物质分离。 此外，各离液剂包括醇物质和用于将醇物质调节至适当浓度的底物溶液，从而促进样品中的核酸与磁性纤维素的结合。

    Dendritic compound and use thereof
    8.
    发明授权
    Dendritic compound and use thereof 失效
    树枝状化合物及其用途

    公开(公告)号：US07732558B2

    公开(公告)日：2010-06-08

    申请号：US11316822

    申请日：2005-12-27

    Applicant: Abraham Josephk ,  Hui-Ju Cho ,  Yu-Hau Shih ,  Chao-Hung Kao ,  Huang-Chien Liang

    Inventor： Abraham Josephk ,  Hui-Ju Cho ,  Yu-Hau Shih ,  Chao-Hung Kao ,  Huang-Chien Liang

    IPC: C08G69/44 ,  A61B5/055

    CPC classification number: A61K49/124

    Abstract: A dendritic compound of the following structure: PDn-Z-L is disclosed. In the structure above, P is X—(CH2CH2—O)r—, r is an integer ranging from 1000 to 4000, X is OH, NH2, or OR, R is C1 to C10alkyl, Dn is a residue of branched C3 to C30 polyol compounds, n is the quantity of layers of the residue of branched compounds and is an integer equal to or greater than 1, L is a metal cation, Z is the residue of a C3 to C30 compound with multi functional groups. The functional groups illustrated above can be carboxylic groups, amino groups, amide groups, or chelating groups. The carboxylic groups, ester groups, amino groups, or amide groups bind to Dn, and the chelating groups bind to the metal cations.

    Abstract translation: 公开了以下结构的树枝状化合物：PDn-Z-L。 在上述结构中，P为X-（CH 2 CH 2 -O）r - ，r为1000〜4000的整数，X为OH，NH 2或OR，R为C1〜C10烷基，Dn为支链C3〜 C30多元醇化合物，n为支链化合物残基的层数，为1以上的整数，L为金属阳离子，Z为具有多官能团的C3〜C30化合物的残基。 上述官能团可以是羧基，氨基，酰胺基或螯合基。 羧基，酯基，氨基或酰胺基与Dn结合，螯合基与金属阳离子结合。

    Analytical method and device utilizing magnetic materials
    10.
    发明授权
    Analytical method and device utilizing magnetic materials 失效
    利用磁性材料的分析方法和装置

    公开(公告)号：US07410811B2

    公开(公告)日：2008-08-12

    申请号：US11320659

    申请日：2005-12-30

    Applicant: Yuh Jiuan Lin ,  Kun Feng Lee ,  Chi Min Chau ,  Hui Ju Cho

    Inventor： Yuh Jiuan Lin ,  Kun Feng Lee ,  Chi Min Chau ,  Hui Ju Cho

    IPC: G01N33/553

    CPC classification number: G01N33/54326 ,  G01N33/54373 ,  Y10S436/805

    Abstract: The present invention relates to an analytical method and device utilizing magnetic materials and acoustics sensor. The invention employs a magnetic material modified with specific recognizable molecules to capture a substance in a sample and provides an external magnetic field to draw the magnetic material to an sensing region of an acoustics sensor, and then converts an effect occurred on a surface of the sensing region to an amount of the substance in the sample, wherein the effect is caused by a contact of the surface with the magnetic material and the substance.

    Abstract translation: 本发明涉及利用磁性材料和声学传感器的分析方法和装置。 本发明采用用特定可识别分子修饰的磁性材料来捕获样品中的物质，并提供外部磁场以将磁性材料吸引到声学传感器的感测区域，然后转换在感测表面上发生的影响 区域相对于样品中物质的量，其中效果是由表面与磁性材料和物质的接触引起的。

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