Anti-FcRn antibodies for treatment of auto/allo immune conditions
    11.
    发明申请
    Anti-FcRn antibodies for treatment of auto/allo immune conditions 有权
    用于治疗自身/同种异体免疫病症的抗FcRn抗体

    公开(公告)号:US20070092507A1

    公开(公告)日:2007-04-26

    申请号:US11634676

    申请日:2006-12-06

    IPC分类号: A61K39/395 C07K16/42

    摘要: Antibodies to heavy chain of human FcRn are provided which function as non-competitive inhibitors of IgG binding to FcRn. The antibodies may be polyclonal, monoclonal, chimeric or humanized, or antigen binding fragments thereof. These antibodies are useful for reducing the concentration of pathogenic IgGs in individuals and therefore used as a therapeutic tool in autoimmune and alloimmune conditions.

    摘要翻译: 提供了人FcRn重链的抗体,其作为结合FcRn的IgG的非竞争性抑制剂起作用。 抗体可以是多克隆,单克隆,嵌合或人源化或其抗原结合片段。 这些抗体可用于降低个体中致病性IgG的浓度,因此用作自身免疫和同种异体免疫条件下的治疗工具。