Anti-FcRn antibodies for treatment of auto/allo immune conditions
    1.
    发明申请
    Anti-FcRn antibodies for treatment of auto/allo immune conditions 有权
    用于治疗自身/同种异体免疫病症的抗FcRn抗体

    公开(公告)号:US20070092507A1

    公开(公告)日:2007-04-26

    申请号:US11634676

    申请日:2006-12-06

    IPC分类号: A61K39/395 C07K16/42

    摘要: Antibodies to heavy chain of human FcRn are provided which function as non-competitive inhibitors of IgG binding to FcRn. The antibodies may be polyclonal, monoclonal, chimeric or humanized, or antigen binding fragments thereof. These antibodies are useful for reducing the concentration of pathogenic IgGs in individuals and therefore used as a therapeutic tool in autoimmune and alloimmune conditions.

    摘要翻译: 提供了人FcRn重链的抗体,其作为结合FcRn的IgG的非竞争性抑制剂起作用。 抗体可以是多克隆,单克隆,嵌合或人源化或其抗原结合片段。 这些抗体可用于降低个体中致病性IgG的浓度,因此用作自身免疫和同种异体免疫条件下的治疗工具。

    Modular display system
    3.
    发明申请
    Modular display system 审中-公开
    模块化显示系统

    公开(公告)号:US20070000849A1

    公开(公告)日:2007-01-04

    申请号:US11271404

    申请日:2005-11-10

    IPC分类号: A47F7/00

    CPC分类号: G09F9/33 G09F9/3026

    摘要: A modular display system having individual stackable electronic display panels of convenient and portable size and mounting structures for the support thereof where the stackable electronic display panels mutually juxtapose, mate, and robustly and mutually and adjustably secure together by the use of connector plates at the top of stackable electronic display panels interfacing with interlocking lower connector assemblies and lower connector plate receptors at the bottom of an overhead vertically situated stackable electronic display panel and by interfacing of latches and cams of latch keeper assemblies at the sides of horizontally situated stackable electronic display panels to form a large electronic sign display. Spring-loaded slide pin assemblies foster rapid and secure connection between vertically situated stackable electronic display panels. Adjustment features are also incorporated to align each stackable electronic display panel.

    摘要翻译: 一种模块化显示系统,具有方便和便携的尺寸和安装结构的单个可堆叠电子显示面板,用于支撑可堆叠电子显示面板,其中堆叠式电子显示面板通过在顶部使用连接器板而互相并排,相互并联并且可调节地固定在一起 可叠置的电子显示面板与互锁的下连接器组件和下部连接器板接收器连接在顶部垂直定位的可堆叠的电子显示面板的底部,并且通过将水平定位的可堆叠的电子显示面板的侧面的闩锁保持器组件的闩锁和凸轮的接口连接到 形成一个大型电子标志显示。 弹簧加载的滑动销组件可以在垂直定位的可堆叠电子显示面板之间建立快速和安全的连接。 还结合了调整特征以对准每个可堆叠的电子显示面板。

    Use of photopolymerization for amplification and detection of a Molecular Recognition Event
    6.
    发明授权
    Use of photopolymerization for amplification and detection of a Molecular Recognition Event 有权
    使用光聚合进行扩增和检测分子识别事件

    公开(公告)号:US08652778B2

    公开(公告)日:2014-02-18

    申请号:US13082814

    申请日:2011-04-08

    IPC分类号: C12Q1/68 C40B30/04 B82Y30/00

    摘要: The invention provides methods to detect molecular recognition events. The invention also provides methods to detect the presence of or identify a target species based on its interaction with one or more probe species. The methods of the invention are based on amplification of the signal due to each molecular recognition event. The amplification is achieved through photopolymerization, with the polymer formed being associated with the molecular recognition event. In one aspect, a fluorescent polymer, a magnetic polymer, a radioactive polymer or an electrically conducting polymer can form the basis of detection and amplification. In another aspect, a polymer gel swollen with a fluorescent solution, a magnetic solution, a radioactive solution or an electrically conducting solution can form the basis of detection and amplification. In another aspect, detectable particles can be included in the polymer formed. In another aspect, sufficient polymer forms to be detectable by visual inspection.

    摘要翻译: 本发明提供检测分子识别事件的方法。 本发明还提供了基于其与一种或多种探针物种的相互作用来检测靶物种的存在或鉴定目的物种的方法。 本发明的方法基于由于每个分子识别事件引起的信号的放大。 通过光聚合实现扩增,形成的聚合物与分子识别事件相关联。 一方面,荧光聚合物,磁性聚合物,放射性聚合物或导电聚合物可以形成检测和扩增的基础。 另一方面,用荧光溶液,磁性溶液,放射性溶液或导电溶液溶胀的聚合物凝胶可以形成检测和扩增的基础。 在另一方面,所形成的聚合物中可以包括可检测的颗粒。 另一方面,足够的聚合物形式可通过视觉检查来检测。

    Device for redirecting boat motor exhaust
    7.
    发明授权
    Device for redirecting boat motor exhaust 失效
    重新定向船用电机排气装置

    公开(公告)号:US07306500B1

    公开(公告)日:2007-12-11

    申请号:US11000669

    申请日:2004-11-30

    IPC分类号: B63H21/34

    摘要: The present invention is a device which redirects motor exhaust fumes a distance away from a boat. This device can be applied to a boat's propulsion motor or to its generator for purposes of preventing carbon monoxide poisoning of a boat's passengers. The device includes an adaptor for attaching to a boat motor exhaust port and an elongate extension hose attached to the adaptor. The extension hose is made buoyant through use of a plurality of flotation collars disposed along the length of the hose. An extension rod is inserted into the collars to keep the hose rigid and the distal exhaust end of the hose directed away from a boat to which the device is attached.

    摘要翻译: 本发明是一种将电动机废气重新排列离船的距离的装置。 该装置可以应用于船的推进马达或其发电机,以防止一小时乘客的一氧化碳中毒。 该装置包括用于附接到船用电机排气口的适配器和连接到适配器的细长延伸软管。 延伸软管通过使用沿着软管的长度设置的多个浮选环制成浮力。 将延伸杆插入套环中以保持软管刚性并且软管的远端排气端远离装置所附接的船。

    Clinical application utilizing genetic data for effective medication management
    8.
    发明申请
    Clinical application utilizing genetic data for effective medication management 审中-公开
    临床应用利用遗传数据进行有效的药物治疗

    公开(公告)号:US20130029862A1

    公开(公告)日:2013-01-31

    申请号:US13488397

    申请日:2012-06-04

    IPC分类号: C40B30/04 C40B40/06

    摘要: The present disclosure relates a predictive method, based on a subject's genetic profile, which defines variability in a specific disease or condition to determine medication response, including determining select VNTR and SNP occurrence combinations which are associated with specific responses to medications, kits and DNA chips/arrays containing such combinations so as to effectuate better medication management.

    摘要翻译: 本公开涉及基于受试者遗传图谱的预测方法,该方法定义特定疾病或病症中的变异性以确定药物应答,包括确定与药物,试剂盒和DNA芯片的特异性反应相关的选择性VNTR和SNP发生组合 /包含这些组合的阵列,以便实现更好的药物管理。

    Use of Photopolymerization for Amplification and Detection of a Molecular Recognition Event
    9.
    发明申请
    Use of Photopolymerization for Amplification and Detection of a Molecular Recognition Event 有权
    使用光聚合扩增和检测分子识别事件

    公开(公告)号:US20110251092A1

    公开(公告)日:2011-10-13

    申请号:US13082814

    申请日:2011-04-08

    IPC分类号: C40B30/04 G01N21/75 B82Y15/00

    摘要: The invention provides methods to detect molecular recognition events. The invention also provides methods to detect the presence of or identify a target species based on its interaction with one or more probe species. The methods of the invention are based on amplification of the signal due to each molecular recognition event. The amplification is achieved through photopolymerization, with the polymer formed being associated with the molecular recognition event. In one aspect, a fluorescent polymer, a magnetic polymer, a radioactive polymer or an electrically conducting polymer can form the basis of detection and amplification. In another aspect, a polymer gel swollen with a fluorescent solution, a magnetic solution, a radioactive solution or an electrically conducting solution can form the basis of detection and amplification. In another aspect, detectable particles can be included in the polymer formed. In another aspect, sufficient polymer forms to be detectable by visual inspection.

    摘要翻译: 本发明提供检测分子识别事件的方法。 本发明还提供了基于其与一种或多种探针物种的相互作用来检测靶物种的存在或鉴定目的物种的方法。 本发明的方法基于由于每个分子识别事件引起的信号的放大。 通过光聚合实现扩增,形成的聚合物与分子识别事件相关联。 一方面,荧光聚合物,磁性聚合物,放射性聚合物或导电聚合物可以形成检测和扩增的基础。 另一方面,用荧光溶液,磁性溶液,放射性溶液或导电溶液溶胀的聚合物凝胶可以形成检测和扩增的基础。 在另一方面,所形成的聚合物中可以包括可检测的颗粒。 另一方面,足够的聚合物形式可通过视觉检查来检测。