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公开(公告)号：US5340715A
公开(公告)日：1994-08-23
申请号：US711783
申请日：1991-06-07
IPC分类号： G01N21/64 , G01N21/27 , G01N21/55 , G01N21/77 , G01N33/552
CPC分类号： G01N21/7703 , G01N21/648 , Y10S435/808 , Y10S436/805 , Y10S436/807
摘要： An evanescent wave sensor and method for use in analyzing one or more media, the sensor including a waveguide having first and second wave propagating surfaces. The waveguide propagates an input signal along the waveguide between the first and second surfaces. The first surface receives a first radiation signal which indicates the presence of a first analyte, and the second surface receives a second radiation signal representing one or both of a second analyte and a reference. The first and second surfaces can both be contacted with a single medium, or with two separate media, and one or more output signals can be detected.
摘要翻译： 一种用于分析一种或多种介质的ev逝波传感器和方法，所述传感器包括具有第一和第二波传播表面的波导。 波导在第一和第二表面之间沿着波导传播输入信号。 第一表面接收指示第一分析物的存在的第一辐射信号，并且第二表面接收表示第二分析物和参考物中的一个或两者的第二辐射信号。 第一和第二表面都可以与单个介质或两个单独的介质接触，并且可以检测一个或多个输出信号。
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公开(公告)号：US4852967A
公开(公告)日：1989-08-01
申请号：US843637
申请日：1986-03-25
CPC分类号： G01N21/7703 , G01N2021/6434 , G01N21/76
摘要： The present invention relates to a novel evanescent wave sensor which can have a high numerical aperture and is capable of being used in various forms of optically-based assays. Unlike previous fiber optical devices, the present sensors do not use any cladding at the contact points.
摘要翻译： 本发明涉及一种新颖的ev逝波传感器，其能够具有高的数值孔径并且能够用于各种形式的光学测定。 与以前的光纤设备不同，本传感器在接触点处不使用任何覆层。
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公开(公告)号：US5738992A
公开(公告)日：1998-04-14
申请号：US629595
申请日：1996-04-09
IPC分类号： G01N21/64 , G01N21/27 , G01N21/55 , G01N21/77 , G01N33/543 , G01N33/552
CPC分类号： G01N21/648 , G01N21/7703 , G01N2021/6439 , G01N2021/7709 , G01N2021/7793 , G01N21/6428 , Y10S435/808 , Y10S436/805
摘要： An evanescent wave system and method including an optical sensor for use in assaying a reference material and at least one molecular species or analyte in a test medium or test sample for diagnostic and other applicable purposes. The sensor includes a waveguide for propagating a radiation input along its length. The radiation input causes evanescent electromagnetic waves that are capable of stimulating output emissions that are indicative of a reference material and of one or more molecular species or analytes. By comparing the emission(s) indicative of the reference material to the emission indicative of the presence of the molecular species or analyte, the presence and concentration of the molecule in the sample can be determined. The reference material provides for normalization and/or calibration of the system.
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公开(公告)号：US5525466A
公开(公告)日：1996-06-11
申请号：US246391
申请日：1994-05-20
IPC分类号： G01N21/64 , G01N21/27 , G01N21/55 , G01N21/77 , G01N33/543 , G01N33/552 , G01N3/68
CPC分类号： G01N21/648 , G01N21/7703 , G01N2021/6439 , G01N2021/7709 , G01N2021/7793 , G01N21/6428 , Y10S435/808 , Y10S436/805
摘要： An evanescent wave system and method including an optical sensor for use in assaying a reference material and at least one molecular species or analyte in a test medium or test sample for diagnostic and other applicable purposes. The sensor includes a waveguide for propagating a radiation input along its length. The radiation input causes evanescent electromagnetic waves that are capable of stimulating output emissions that are indicative of a reference material and of one or more molecular species or analytes. By comparing the emission(s) indicative of the reference material to the emission indicative of the presence of the molecular species or analyte, the presence and concentration of the molecule in the sample can be determined. The reference material provides for normalization and/or calibration of the system.
摘要翻译： 一种ev逝波系统和方法，包括用于测定参考材料的光学传感器和用于诊断和其他适用目的的测试介质或测试样品中的至少一种分子种类或分析物。 传感器包括用于沿其长度传播辐射输入的波导。 辐射输入引起能够刺激指示参考物质和一种或多种分子种类或分析物的输出排放的ev逝电磁波。 通过将指示参考物质的排放与指示分子物质或分析物的存在的排放进行比较，可以确定样品中分子的存在和浓度。 参考资料提供了系统的归一化和/或校准。
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15.发明授权Method for the rapid detection of analytes involving specific binding reactions and the use of light attenuating magnetic particles 失效用于快速检测涉及特异性结合反应的分析物和使用光衰减磁性颗粒的方法
公开(公告)号：US5242837A
公开(公告)日：1993-09-07
申请号：US632991
申请日：1990-12-24
IPC分类号： G01N33/543
CPC分类号： G01N33/54366 , Y10S436/80 , Y10S436/805
摘要： The present invention relates to an optical apparatus and a uniaxial method for rapidly measuring spectroscopically labelled specific binding analytes in a reaction assay mixture that contains unbound label without requiring the physical separation of the unbound label from the reaction mixture or sequential reagant additions and incubations. Moreover, the technique is equally applicable to measurements in either serum or whole blood.
摘要翻译： 本发明涉及用于在反应测定混合物中快速测量光谱标记的特异性结合分析物的光学装置和单轴方法，所述反应测定混合物含有未结合的标记而不需要将未结合的标记与反应混合物物理分离或连续的反应物添加和温育。 此外，该技术同样适用于血清或全血中的测量。
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公开(公告)号：US5156976A
公开(公告)日：1992-10-20
申请号：US712003
申请日：1991-06-07
申请人： Rudolf E. Slovacek , Walter F. Love
发明人： Rudolf E. Slovacek , Walter F. Love
IPC分类号： G01N21/03 , G01N21/27 , G01N21/55 , G01N21/64 , G01Q30/14 , G01Q60/00 , G01Q70/08 , G01Q70/10 , G01Q80/00
CPC分类号： G01N21/648 , G01N21/552 , G01N21/7703 , Y10S435/808 , Y10S436/805 , Y10S436/807
摘要： An evanescent wave sensor for use in analyzing a medium, the sensor including a shell having a radiation port at a first end and a base at a second end. The base has a dimension greater than that of the radiation port, and inner and outer wall surfaces of the shell extend between the radiation port and the base. The shell is formed of a material having an index of refraction greater than that of the medium. An apparatus and method for analyzing the medium using the sensor may include a receptacle which defines a chamber about a portion of the shell for contacting the medium to the shell for analysis, optical elements for guiding radiation from a radiation source to the radiation port, and optical elements for guiding fluorescent radiation from the shell to a detector of fluorescent radiation.
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