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1.发明授权Method of operating an optical sensor adapted for selective analyte-sensing contact with a plurality of samples 有权操作适于与多个样品进行选择性分析物感测接触的光学传感器的方法公开(公告)号：US06387709B1
公开(公告)日：2002-05-14
申请号：US09941807
申请日：2001-08-29
IPC分类号： G01N2101
CPC分类号： G01N21/8483 , Y10T436/10
摘要： A multiple single use optical sensor includes a series of continuous sensor stripes deposited on a substrate web. At least one sample chamber is adapted to extend transversely across a discrete portion of the series of sensor stripes to facilitate analysis of a sample disposed therein. The sample chamber may be moved, or additional sample chambers provided to enable subsequent measurements of additional samples at unused discrete portions of the sensor stripes. The continuous nature of the sensor stripes provides consistency along the lengths thereof to enable calibration data obtained from one discrete portion of the sensor stripes to be utilized for testing an unknown sample an other discrete portion of the sensor stripes. This advantageously eliminates the need for any particular discrete portion of the sensor stripes to be contacted by more than one sample, for improved sensor performance.
摘要翻译： 多用途光学传感器包括沉积在基片网上的一系列连续传感器条纹。 至少一个样品室适于横向延伸穿过该系列传感器条的离散部分，以便于分析其中设置的样品。 可以移动样品室，或者提供附加的样品室，以便能够在传感器条纹的未使用的分立部分的后续测量附加样品。 传感器条带的连续性质提供沿其长度的一致性，使得从传感器条的一个离散部分获得的校准数据可用于测试未知样品传感器条纹的其他离散部分。 这有利地消除了对传感器条的任何特定离散部分与多于一个样品的接触的需要，以提高传感器性能。
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公开(公告)号：US5340715A
公开(公告)日：1994-08-23
申请号：US711783
申请日：1991-06-07
IPC分类号： G01N21/64 , G01N21/27 , G01N21/55 , G01N21/77 , G01N33/552
CPC分类号： G01N21/7703 , G01N21/648 , Y10S435/808 , Y10S436/805 , Y10S436/807
摘要： An evanescent wave sensor and method for use in analyzing one or more media, the sensor including a waveguide having first and second wave propagating surfaces. The waveguide propagates an input signal along the waveguide between the first and second surfaces. The first surface receives a first radiation signal which indicates the presence of a first analyte, and the second surface receives a second radiation signal representing one or both of a second analyte and a reference. The first and second surfaces can both be contacted with a single medium, or with two separate media, and one or more output signals can be detected.
摘要翻译： 一种用于分析一种或多种介质的ev逝波传感器和方法，所述传感器包括具有第一和第二波传播表面的波导。 波导在第一和第二表面之间沿着波导传播输入信号。 第一表面接收指示第一分析物的存在的第一辐射信号，并且第二表面接收表示第二分析物和参考物中的一个或两者的第二辐射信号。 第一和第二表面都可以与单个介质或两个单独的介质接触，并且可以检测一个或多个输出信号。
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公开(公告)号：US4852967A
公开(公告)日：1989-08-01
申请号：US843637
申请日：1986-03-25
CPC分类号： G01N21/7703 , G01N2021/6434 , G01N21/76
摘要： The present invention relates to a novel evanescent wave sensor which can have a high numerical aperture and is capable of being used in various forms of optically-based assays. Unlike previous fiber optical devices, the present sensors do not use any cladding at the contact points.
摘要翻译： 本发明涉及一种新颖的ev逝波传感器，其能够具有高的数值孔径并且能够用于各种形式的光学测定。 与以前的光纤设备不同，本传感器在接触点处不使用任何覆层。
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公开(公告)号：US06368869B2
公开(公告)日：2002-04-09
申请号：US09775332
申请日：2001-01-31
IPC分类号： G01N2164
CPC分类号： G01N21/6428 , G01N2021/7786
摘要： A liquid permeable metallic coating is utilized in conjunction with a fluorescence based optical sensor. The metallic coating is deposited directly on, and is in physical contact with, the sensing membrane. The metallic coating does not require an intervening substrate layer or other components. When light from a light source is shone through the substantially light transmissive substrate onto the sensing membrane, the metallic overcoating reflects back the excitation light as well as the fluorescence light generated by the sensor such that substantially no light reaches the sample where the light may be scattered and/or absorbed by the sample. Accordingly, the accuracy and repeatability of the sensor is improved while the cost and production times associated with manufacturing the sensor are minimized.
摘要翻译： 液体可渗透的金属涂层与荧光基光学传感器结合使用。 金属涂层直接沉积在感测膜上并与传感膜物理接触。 金属涂层不需要中间衬底层或其它部件。 当来自光源的光通过基本上透光的基底照射到感测膜上时，金属外涂层反射激发光以及由传感器产生的荧光，使得基本上没有光到达光可以是样品 被样品分散和/或吸收。 因此，传感器的精度和重复性得到改善，同时与生产传感器相关的成本和生产时间最小化。
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公开(公告)号：US5738992A
公开(公告)日：1998-04-14
申请号：US629595
申请日：1996-04-09
IPC分类号： G01N21/64 , G01N21/27 , G01N21/55 , G01N21/77 , G01N33/543 , G01N33/552
CPC分类号： G01N21/648 , G01N21/7703 , G01N2021/6439 , G01N2021/7709 , G01N2021/7793 , G01N21/6428 , Y10S435/808 , Y10S436/805
摘要： An evanescent wave system and method including an optical sensor for use in assaying a reference material and at least one molecular species or analyte in a test medium or test sample for diagnostic and other applicable purposes. The sensor includes a waveguide for propagating a radiation input along its length. The radiation input causes evanescent electromagnetic waves that are capable of stimulating output emissions that are indicative of a reference material and of one or more molecular species or analytes. By comparing the emission(s) indicative of the reference material to the emission indicative of the presence of the molecular species or analyte, the presence and concentration of the molecule in the sample can be determined. The reference material provides for normalization and/or calibration of the system.
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公开(公告)号：US5525466A
公开(公告)日：1996-06-11
申请号：US246391
申请日：1994-05-20
IPC分类号： G01N21/64 , G01N21/27 , G01N21/55 , G01N21/77 , G01N33/543 , G01N33/552 , G01N3/68
CPC分类号： G01N21/648 , G01N21/7703 , G01N2021/6439 , G01N2021/7709 , G01N2021/7793 , G01N21/6428 , Y10S435/808 , Y10S436/805
摘要： An evanescent wave system and method including an optical sensor for use in assaying a reference material and at least one molecular species or analyte in a test medium or test sample for diagnostic and other applicable purposes. The sensor includes a waveguide for propagating a radiation input along its length. The radiation input causes evanescent electromagnetic waves that are capable of stimulating output emissions that are indicative of a reference material and of one or more molecular species or analytes. By comparing the emission(s) indicative of the reference material to the emission indicative of the presence of the molecular species or analyte, the presence and concentration of the molecule in the sample can be determined. The reference material provides for normalization and/or calibration of the system.
摘要翻译： 一种ev逝波系统和方法，包括用于测定参考材料的光学传感器和用于诊断和其他适用目的的测试介质或测试样品中的至少一种分子种类或分析物。 传感器包括用于沿其长度传播辐射输入的波导。 辐射输入引起能够刺激指示参考物质和一种或多种分子种类或分析物的输出排放的ev逝电磁波。 通过将指示参考物质的排放与指示分子物质或分析物的存在的排放进行比较，可以确定样品中分子的存在和浓度。 参考资料提供了系统的归一化和/或校准。
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公开(公告)号：US06306347B1
公开(公告)日：2001-10-23
申请号：US09010096
申请日：1998-01-21
IPC分类号： G01N2101
CPC分类号： G01N21/8483 , Y10T436/10
摘要： A multiple single use optical sensor includes a series of continuous sensor stripes deposited on a substrate web. At least one sample chamber is adapted to extend transversely across a discrete portion of the series of sensor stripes to facilitate analysis of a sample disposed therein. The sample chamber may be moved, or additional sample chambers provided to enable subsequent measurements of additional samples at unused discrete portions of the sensor stripes. The continuous nature of the sensor stripes provides consistency along the lengths thereof to enable calibration data obtained from one discrete portion of the sensor stripes to be utilized for testing an unknown sample an other discrete portion of the sensor stripes. This advantageously eliminates the need for any particular discrete portion of the sensor stripes to be contacted by more than one sample, for improved sensor performance.
摘要翻译： 多用途光学传感器包括沉积在基片网上的一系列连续传感器条纹。 至少一个样品室适于横向延伸穿过该系列传感器条的离散部分，以便于分析其中设置的样品。 可以移动样品室，或者提供附加的样品室，以便能够在传感器条纹的未使用的分立部分的后续测量附加样品。 传感器条带的连续性质提供沿其长度的一致性，使得从传感器条的一个离散部分获得的校准数据可用于测试未知样品传感器条纹的其他离散部分。 这有利地消除了对传感器条的任何特定离散部分与多于一个样品的接触的需要，以提高传感器性能。
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公开(公告)号：US06207110B1
公开(公告)日：2001-03-27
申请号：US09137728
申请日：1998-08-21
IPC分类号： G01N2164
CPC分类号： G01N21/6428 , G01N2021/7786
摘要： A liquid permeable metallic coating is utilized in conjunction with a fluorescence based optical sensor. The metallic coating is deposited directly on, and is in physical contact with, the sensing membrane. The metallic coating does not require an intervening substrate layer or other components. When light from a light source is shone through the substantially light transmissive substrate onto the sensing membrane, the metallic overcoating reflects back the excitation light as well as the fluorescence light generated by the sensor such that substantially no light reaches the sample where the light may be scattered and/or absorbed by the sample. Accordingly, the accuracy and repeatability of the sensor is improved while the cost and production times associated with manufacturing the sensor are minimized.
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公开(公告)号：US6074607A
公开(公告)日：2000-06-13
申请号：US231546
申请日：1999-01-14
CPC分类号： G01N21/643 , G01N31/22 , G01N31/225 , G01N21/05 , Y10T436/207497 , Y10T436/209163
摘要： A polymeric sensing membrane having a Stern-Volmer constant within a pre-determined range of Stern-Volmer constants. The membrane includes a polymeric material having a fluorescent dye molecule dispersed therein. The dye molecule is capable of having its fluorescence collisionally quenched by a gas to be detected by the membrane. In one embodiment, the membrane includes a fluorescent dye molecule which has a relaxation time and a polymeric material having a permeability within a range of permeabilities defined by a mathematical function of the pre-determined range of Stern-Volmer constants. In another embodiment, the membrane includes a polymeric having a permeability and a fluorescent dye molecule having a relaxation time within a range of relaxation times defined by a mathematical function of the pre-determined range of Stern-Volmer constants.
摘要翻译： 一种聚合物传感膜，其具有在Stern-Volmer常数的预定范围内的斯特 - 沃尔默常数。 膜包括其中分散有荧光染料分子的聚合物材料。 染料分子能够通过被膜检测的气体使其荧光发生碰撞猝灭。 在一个实施方案中，膜包括具有松弛时间的荧光染料分子和具有由预定范围的斯特 - 沃尔默常数的数学函数定义的渗透性范围内的渗透性的聚合物材料。 在另一个实施方案中，膜包括具有渗透性的聚合物和荧光染料分子，其弛豫时间在松弛时间的范围内，其由Stern-Volmer常数的预定范围的数学函数限定。
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公开(公告)号：US06190612B1
公开(公告)日：2001-02-20
申请号：US09010161
申请日：1998-01-21
IPC分类号： G01N2164
CPC分类号： G01N31/225
摘要： Optical sensor formulations comprising polymeric sensing formulations and methods of predictably making optical sensor formulations, for, e.g., measuring O2 levels in patient blood samples. These formulations may be, e.g., deposited as a membrane on light-transmissive substrates. In an embodiment, O2-sensing formulations may be made by a process including selecting a first homopolymer comprised of first monomeric units, the first homopolymer having a first PermO2 value; selecting a second homopolymer comprised of second monomeric units, the second homopolymer having a second PermO2 value that is different from the first PermO2 value; and copolymerizing the first and second monomeric units to obtain a copolymer having an intermediate PermO2 value, i.e., between the two PermO2 values, the intermediate PermO2 providing the desired PermO2 for the desired oxygen sensing formulation. By adjusting the relative amounts of the first and second monomeric units, a series of polymers having a desired range of intermediate permeability values (and hence Stem-Volmer characteristic kSV values) may be obtained.
摘要翻译： 包括聚合物感测配方的光学传感器配方和可预测地制造光学传感器配方的方法，例如测量患者血液样品中的O 2水平。 这些制剂可以例如在透光性基材上作为膜沉积。 在一个实施方案中，O 2感测制剂可以通过包括选择由第一单体单元组成的第一均聚物，第一均聚物具有第一PermO 2值的方法制备; 选择由第二单体单元组成的第二均聚物，所述第二均聚物具有不同于第一PermO 2值的第二PermO 2值; 并且使第一和第二单体单元共聚以获得具有中等PermO 2值，即两个PermO 2值之间的中间体PermO 2，为所需的氧气感测配方提供期望的PermO 2的共聚物。 通过调节第一和第二单体单元的相对量，可以获得具有期望范围的中间渗透率值（并因此具有Stem-Volmer特征kSV值）的一系列聚合物。
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