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公开(公告)号：US20190126045A1
公开(公告)日：2019-05-02
申请号：US16234097
申请日：2018-12-27
Applicant: LivaNova USA, Inc. , East Tennessee State University
Inventor： Imad Libbus , Badri Amurthur , Bruce H. KenKnight , Jeffrey L. Ardell
Abstract: Systems and methods are provided for delivering neurostimulation therapies to patients for treating chronic heart failure. A neural fulcrum zone is identified and ongoing neurostimulation therapy is delivered within the neural fulcrum zone. The implanted stimulation device includes a physiological sensor for monitoring the patient's response to the neurostimulation therapy on an ambulatory basis over extended periods of time and a control system for adjusting stimulation parameters to maintain stimulation in the neural fulcrum zone based on detected changes in the physiological response to stimulation.
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公开(公告)号：US20220226657A1
公开(公告)日：2022-07-21
申请号：US17716807
申请日：2022-04-08
Applicant: LivaNova USA, Inc. , East Tennessee State University
Inventor： Imad Libbus , Badri Amurthur , Bruce H. KenKnight , Jeffrey L. Ardell
Abstract: Systems and methods are provided for delivering neurostimulation therapies to patients for treating chronic heart failure. A neural fulcrum zone is identified and ongoing neurostimulation therapy is delivered within the neural fulcrum zone. The implanted stimulation device includes a physiological sensor for monitoring the patient's response to the neurostimulation therapy on an ambulatory basis over extended periods of time and a control system for adjusting stimulation parameters to maintain stimulation in the neural fulcrum zone based on detected changes in the physiological response to stimulation.
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公开(公告)号：US11298543B2
公开(公告)日：2022-04-12
申请号：US16234097
申请日：2018-12-27
Applicant: LivaNova USA, Inc. , East Tennessee State University
Inventor： Imad Libbus , Badri Amurthur , Bruce H. KenKnight , Jeffrey L. Ardell
Abstract: Systems and methods are provided for delivering neurostimulation therapies to patients for treating chronic heart failure. A neural fulcrum zone is identified and ongoing neurostimulation therapy is delivered within the neural fulcrum zone. The implanted stimulation device includes a physiological sensor for monitoring the patient's response to the neurostimulation therapy on an ambulatory basis over extended periods of time and a control system for adjusting stimulation parameters to maintain stimulation in the neural fulcrum zone based on detected changes in the physiological response to stimulation.
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公开(公告)号：US20180117333A1
公开(公告)日：2018-05-03
申请号：US15805062
申请日：2017-11-06
Applicant: CYBERONICS, INC. , East Tennessee State University
Inventor： Imad Libbus , Badri Amurthur , Bruce H. KenKnight , Jeffrey L. Ardell
CPC classification number: A61N1/36114 , A61N1/36053 , A61N1/36135 , A61N1/36139 , A61N1/3615 , A61N1/37217 , A61N1/37264
Abstract: Systems and methods are provided for delivering neurostimulation therapies to patients for treating chronic heart failure. A neural fulcrum zone is identified and ongoing neurostimulation therapy is delivered within the neural fulcrum zone. The implanted stimulation device includes a physiological sensor for monitoring the patient's response to the neurostimulation therapy on an ambulatory basis over extended periods of time and a control system for adjusting stimulation parameters to maintain stimulation in the neural fulcrum zone based on detected changes in the physiological response to stimulation.
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15.发明授权公开(公告)号：US09446237B2
公开(公告)日：2016-09-20
申请号：US14861390
申请日：2015-09-22
Applicant: CYBERONICS, INC. , East Tennessee State University
Inventor： Imad Libbus , Badri Amurthur , Bruce H. KenKnight , Jeffrey L. Ardell
CPC classification number: A61N1/36114 , A61N1/36053 , A61N1/36135 , A61N1/36139 , A61N1/3615 , A61N1/37217 , A61N1/37264
Abstract: Systems and methods are provided for delivering neurostimulation therapies to patients for treating chronic heart failure. A neural fulcrum zone is identified and ongoing neurostimulation therapy is delivered within the neural fulcrum zone. The implanted stimulation device includes a physiological sensor for monitoring the patient's response to the neurostimulation therapy on an ambulatory basis over extended periods of time and a control system for adjusting stimulation parameters to maintain stimulation in the neural fulcrum zone based on detected changes in the physiological response to stimulation.
Abstract translation: 提供系统和方法用于向患者提供神经刺激疗法用于治疗慢性心力衰竭。 识别神经支点区域，并在神经支点区域内递送正在进行的神经刺激治疗。 植入的刺激装置包括生理传感器，用于在延长的时间段内基于动态监测患者对神经刺激疗法的反应，以及控制系统，用于根据检测到的生理反应的变化调整刺激参数以维持神经支点区域中的刺激 刺激。
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Patent Agency Ranking
16.发明授权公开(公告)号：US10195438B2
公开(公告)日：2019-02-05
申请号：US15783941
申请日：2017-10-13
Applicant: CYBERONICS, INC. , EAST TENNESSEE STATE UNIVERSITY
Inventor： Imad Libbus , Badri Amurthur , Bruce H. KenKnight , Jeffrey L. Ardell
Abstract: Systems and methods are provided for delivering neurostimulation therapies to patients for treating chronic heart failure. A neural fulcrum zone is identified and ongoing neurostimulation therapy is delivered within the neural fulcrum zone. The implanted stimulation device includes a physiological sensor for recording the patient's response to the neurostimulation therapy on an ambulatory basis over extended periods of time.
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17.发明申请公开(公告)号：US20170319854A1
公开(公告)日：2017-11-09
申请号：US15600519
申请日：2017-05-19
Applicant: CYBERONICS, INC. , EAST TENNESSEE STATE UNIVERSITY
Inventor： Bruce H. KenKnight , Jeffrey L. Ardell , Imad Libbus , Badri Amurthur
IPC: A61N1/36
CPC classification number: A61N1/36139 , A61N1/36053 , A61N1/36114 , A61N1/3615
Abstract: Systems and methods are provided for delivering neurostimulation therapies to patients for treating chronic heart failure. A neural fulcrum zone is identified and ongoing neurostimulation therapy is delivered within the neural fulcrum zone. This neural fulcrum zone corresponds to a combination of stimulation parameters at which autonomic engagement is achieved, while the tachycardia-inducing stimulation effects are offset by the bradycardia-inducing effects, thereby minimizing side effects such as significant heart rate changes while providing a therapeutic level of stimulation.
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公开(公告)号：US09808626B2
公开(公告)日：2017-11-07
申请号：US15267922
申请日：2016-09-16
Applicant: CYBERONICS, INC. , East Tennessee State University
Inventor： Imad Libbus , Badri Amurthur , Bruce H. KenKnight , Jeffrey L. Ardell
CPC classification number: A61N1/36114 , A61N1/36053 , A61N1/36135 , A61N1/36139 , A61N1/3615 , A61N1/37217 , A61N1/37264
Abstract: Systems and methods are provided for delivering neurostimulation therapies to patients for treating chronic heart failure. A neural fulcrum zone is identified and ongoing neurostimulation therapy is delivered within the neural fulcrum zone. The implanted stimulation device includes a physiological sensor for monitoring the patient's response to the neurostimulation therapy on an ambulatory basis over extended periods of time and a control system for adjusting stimulation parameters to maintain stimulation in the neural fulcrum zone based on detected changes in the physiological response to stimulation.
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19.发明申请公开(公告)号：US20170296824A1
公开(公告)日：2017-10-19
申请号：US15585742
申请日：2017-05-03
Applicant: CYBERONICS, INC. , EAST TENNESSEE STATE UNIVERSITY
Inventor： Bruce H. KenKnight , Imad Libbus , Badri Amurthur , Jeffrey L. Ardell
CPC classification number: A61N1/36139 , A61N1/36053 , A61N1/36114 , A61N1/36157 , A61N1/36171 , A61N1/3627
Abstract: Systems and methods are provided for delivering neurostimulation therapies to patients for treating chronic heart failure. A neural fulcrum zone is identified and ongoing neurostimulation therapy is delivered within the neural fulcrum zone. This neural fulcrum zone may be identified by monitoring a patient's response to incrementally increased intensity settings at a first frequency. If the incremental intensity increases do not result in the identification of the neural fulcrum zone, the frequency may be changed to provide finer resolution identification of the neural fulcrum zone.
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20.发明授权公开(公告)号：US09669220B2
公开(公告)日：2017-06-06
申请号：US15230023
申请日：2016-08-05
Applicant: CYBERONICS, INC. , EAST TENNESSEE STATE UNIVERSITY
Inventor： Bruce H. KenKnight , Jeffrey L. Ardell , Imad Libbus , Badri Amurthur
IPC: A61N1/36
CPC classification number: A61N1/36139 , A61N1/36053 , A61N1/36114 , A61N1/3615
Abstract: Systems and methods are provided for delivering neurostimulation therapies to patients for treating chronic heart failure. A neural fulcrum zone is identified and ongoing neurostimulation therapy is delivered within the neural fulcrum zone. This neural fulcrum zone corresponds to a combination of stimulation parameters at which autonomic engagement is achieved, while the tachycardia-inducing stimulation effects are offset by the bradycardia-inducing effects, thereby minimizing side effects such as significant heart rate changes while providing a therapeutic level of stimulation.
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