-
公开(公告)号：US20250065122A1
公开(公告)日：2025-02-27
申请号：US18947702
申请日：2024-11-14
Applicant: LivaNova USA, Inc. , East Tennessee State University
Inventor： Imad Libbus , Badri Amurthur , Bruce H. KenKnight , Jeffrey L. Ardell
Abstract: A method may include delivering stimulation to a nerve of a patient using a first set of stimulation parameters. The method may further include detecting a first heart rate change within a range between a baseline heart rate and a predefined threshold. The method may further include, subsequent to detecting the first heart rate change, detecting a second heart rate change that is outside of the range between the baseline heart rate and the predefined threshold. The method may further include delivering stimulation to the nerve of the patient using a second set of stimulation parameters based on the second heart rate change being outside of the range between the baseline heart rate and the predefined threshold.
-
2.发明授权公开(公告)号：US11738199B2
公开(公告)日：2023-08-29
申请号：US17390481
申请日：2021-07-30
Applicant: LivaNova USA, Inc. , EAST TENNESSEE STATE UNIVERSITY
Inventor： Bruce H. KenKnight , Jeffrey L. Ardell , Imad Libbus , Badri Amurthur
IPC: A61N1/36
CPC classification number: A61N1/36139 , A61N1/3615 , A61N1/36053 , A61N1/36114
Abstract: Systems and methods are provided for delivering neurostimulation therapies to patients for treating chronic heart failure. A neural fulcrum zone is identified and ongoing neurostimulation therapy is delivered within the neural fulcrum zone. This neural fulcrum zone corresponds to a combination of stimulation parameters at which autonomic engagement is achieved, while the tachycardia-inducing stimulation effects are offset by the bradycardia-inducing effects, thereby minimizing side effects such as significant heart rate changes while providing a therapeutic level of stimulation.
-
3.发明申请公开(公告)号：US20220016429A1
公开(公告)日：2022-01-20
申请号：US17390481
申请日：2021-07-30
Applicant: LivaNova USA, Inc. , EAST TENNESSEE STATE UNIVERSITY
Inventor： Bruce H. KenKnight , Jeffrey L. Ardell , Imad Libbus , Badri Amurthur
IPC: A61N1/36
Abstract: Systems and methods are provided for delivering neurostimulation therapies to patients for treating chronic heart failure. A neural fulcrum zone is identified and ongoing neurostimulation therapy is delivered within the neural fulcrum zone. This neural fulcrum zone corresponds to a combination of stimulation parameters at which autonomic engagement is achieved, while the tachycardia-inducing stimulation effects are offset by the bradycardia-inducing effects, thereby minimizing side effects such as significant heart rate changes while providing a therapeutic level of stimulation.
-
4.发明授权公开(公告)号：US10300284B2
公开(公告)日：2019-05-28
申请号：US15600519
申请日：2017-05-19
Applicant: LivaNova USA, Inc. , EAST TENNESSEE STATE UNIVERSITY
Inventor： Bruce H. KenKnight , Jeffrey L. Ardell , Imad Libbus , Badri Amurthur
IPC: A61N1/36
Abstract: Systems and methods are provided for delivering neurostimulation therapies to patients for treating chronic heart failure. A neural fulcrum zone is identified and ongoing neurostimulation therapy is delivered within the neural fulcrum zone. This neural fulcrum zone corresponds to a combination of stimulation parameters at which autonomic engagement is achieved, while the tachycardia-inducing stimulation effects are offset by the bradycardia-inducing effects, thereby minimizing side effects such as significant heart rate changes while providing a therapeutic level of stimulation.
-
公开(公告)号：US12157008B2
公开(公告)日：2024-12-03
申请号：US17716807
申请日：2022-04-08
Applicant: LivaNova USA, Inc. , East Tennessee State University
Inventor： Imad Libbus , Badri Amurthur , Bruce H. KenKnight , Jeffrey L. Ardell
Abstract: Systems and methods are provided for delivering neurostimulation therapies to patients for treating chronic heart failure. A neural fulcrum zone is identified and ongoing neurostimulation therapy is delivered within the neural fulcrum zone. The implanted stimulation device includes a physiological sensor for monitoring the patient's response to the neurostimulation therapy on an ambulatory basis over extended periods of time and a control system for adjusting stimulation parameters to maintain stimulation in the neural fulcrum zone based on detected changes in the physiological response to stimulation.
-
Patent Agency Ranking
公开(公告)号：US10967184B2
公开(公告)日：2021-04-06
申请号：US16265765
申请日：2019-02-01
Applicant: LIVANOVA USA, INC. , EAST TENNESSEE STATE UNIVERSITY
Inventor： Imad Libbus , Badri Amurthur , Bruce H. KenKnight , Jeffrey L. Ardell
Abstract: Systems and methods are provided for delivering neurostimulation therapies to patients for treating chronic heart failure. A neural fulcrum zone is identified and ongoing neurostimulation therapy is delivered within the neural fulcrum zone. The implanted stimulation device includes a physiological sensor for recording the patient's response to the neurostimulation therapy on an ambulatory basis over extended periods of time.
-
7.发明申请公开(公告)号：US20190168001A1
公开(公告)日：2019-06-06
申请号：US16265765
申请日：2019-02-01
Applicant: LIVANOVA USA, INC. , EAST TENNESSEE STATE UNIVERSITY
Inventor： Imad Libbus , Badri Amurthur , Bruce H. KenKnight , Jeffrey L. Ardell
Abstract: Systems and methods are provided for delivering neurostimulation therapies to patients for treating chronic heart failure. A neural fulcrum zone is identified and ongoing neurostimulation therapy is delivered within the neural fulcrum zone. The implanted stimulation device includes a physiological sensor for recording the patient's response to the neurostimulation therapy on an ambulatory basis over extended periods of time.
-
8.发明授权公开(公告)号：US11077304B2
公开(公告)日：2021-08-03
申请号：US16422588
申请日：2019-05-24
Applicant: LivaNova USA, Inc. , EAST TENNESSEE STATE UNIVERSITY
Inventor： Bruce H. KenKnight , Jeffrey L. Ardell , Imad Libbus , Badri Amurthur
IPC: A61N1/36
Abstract: Systems and methods are provided for delivering neurostimulation therapies to patients for treating chronic heart failure. A neural fulcrum zone is identified and ongoing neurostimulation therapy is delivered within the neural fulcrum zone. This neural fulcrum zone corresponds to a combination of stimulation parameters at which autonomic engagement is achieved, while the tachycardia-inducing stimulation effects are offset by the bradycardia-inducing effects, thereby minimizing side effects such as significant heart rate changes while providing a therapeutic level of stimulation.
-
9.发明授权公开(公告)号：US10974050B2
公开(公告)日：2021-04-13
申请号：US16009099
申请日：2018-06-14
Applicant: LivaNova USA, Inc. , East Tennessee State University
Inventor： Imad Libbus , Badri Amurthur , Bruce H. KenKnight , Jeffrey L. Ardell , Gregory A. Ordway
Abstract: Multi-modal stimulation therapy may be utilized in which two or more stimulation therapies having different stimulation parameters may be delivered to a single patient. This can preferentially stimulate different nerve fiber types and drive different functional responses in the target organs. The stimulation parameters that may vary between the different stimulation therapies include, for example, pulse frequency, pulse width, pulse amplitude, and duty cycle.
-
10.发明授权公开(公告)号：US10463859B2
公开(公告)日：2019-11-05
申请号：US15585742
申请日：2017-05-03
Applicant: LivaNova USA, Inc. , EAST TENNESSEE STATE UNIVERSITY
Inventor： Bruce H. KenKnight , Imad Libbus , Badri Amurthur , Jeffrey L. Ardell
Abstract: Systems and methods are provided for delivering neurostimulation therapies to patients for treating chronic heart failure. A neural fulcrum zone is identified and ongoing neurostimulation therapy is delivered within the neural fulcrum zone. This neural fulcrum zone may be identified by monitoring a patient's response to incrementally increased intensity settings at a first frequency. If the incremental intensity increases do not result in the identification of the neural fulcrum zone, the frequency may be changed to provide finer resolution identification of the neural fulcrum zone.
-
-
-
-
-
-
-
-
-
Search Results
83
records
(took 0.028 seconds)
