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公开(公告)号:US20240399153A1
公开(公告)日:2024-12-05
申请号:US18731997
申请日:2024-06-03
Applicant: LivaNova USA, Inc.
Inventor: Scott Stubbs , Imad Libbus , Scott Mazar , Bruce KenKnight , Badri Amurthur
Abstract: Systems and methods for customizable titration of an implantable neurostimulator are provided. A method of titrating a neurostimulation signal delivered to a patient from an implantable pulse generator includes delivering a first neurostimulation signal with a first set of parameters, increasing a first value of the first neurostimulation signal at a first rate for a first period of time while delivering the first neurostimulation signal, ceasing delivery of the first neurostimulation signal when the first value reaches a first target value, delivering a second neurostimulation signal with a second set of parameters, and increasing the second neurostimulation signal at a second rate for a second period of time while delivering the second neurostimulation signal.
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公开(公告)号:US12157008B2
公开(公告)日:2024-12-03
申请号:US17716807
申请日:2022-04-08
Applicant: LivaNova USA, Inc. , East Tennessee State University
Inventor: Imad Libbus , Badri Amurthur , Bruce H. KenKnight , Jeffrey L. Ardell
Abstract: Systems and methods are provided for delivering neurostimulation therapies to patients for treating chronic heart failure. A neural fulcrum zone is identified and ongoing neurostimulation therapy is delivered within the neural fulcrum zone. The implanted stimulation device includes a physiological sensor for monitoring the patient's response to the neurostimulation therapy on an ambulatory basis over extended periods of time and a control system for adjusting stimulation parameters to maintain stimulation in the neural fulcrum zone based on detected changes in the physiological response to stimulation.
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公开(公告)号:US12076566B2
公开(公告)日:2024-09-03
申请号:US17129467
申请日:2020-12-21
Applicant: LivaNova USA, Inc.
Inventor: Imad Libbus , Bruce H. KenKnight
IPC: A61N1/36 , A61B5/349 , A61N1/05 , A61N1/37 , A61N1/372 , G16H20/30 , G16H20/40 , G16H40/20 , G16H40/63 , G16Z99/00
CPC classification number: A61N1/36139 , A61B5/349 , A61N1/0551 , A61N1/36114 , A61N1/36132 , A61N1/3615 , A61N1/36167 , A61N1/3702 , A61N1/37223 , A61N1/37235 , G16H20/30 , G16H20/40 , G16H40/20 , G16H40/63 , G16Z99/00
Abstract: Systems and methods are provided for delivering neurostimulation therapies to patients. A titration process is used to gradually increase the stimulation intensity to a desired therapeutic level until a target T-wave alternans change from a baseline T-wave alternans is achieved.
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公开(公告)号:US11865344B2
公开(公告)日:2024-01-09
申请号:US16705043
申请日:2019-12-05
Applicant: LivaNova USA, Inc.
Inventor: Imad Libbus , Bruce H. KenKnight , Badri Amurthur , Scott R. Stubbs
IPC: A61N1/36 , A61N1/05 , G16H40/63 , A61N1/37 , G16Z99/00 , G16H40/20 , G16H20/30 , A61B5/349 , A61N1/372 , G16H20/40
CPC classification number: A61N1/36139 , A61B5/349 , A61N1/0551 , A61N1/3615 , A61N1/36114 , A61N1/36132 , A61N1/36167 , A61N1/3702 , A61N1/37223 , A61N1/37235 , G16H20/30 , G16H20/40 , G16H40/20 , G16H40/63 , G16Z99/00
Abstract: Systems and methods are provided for delivering neurostimulation therapies to patients. A titration process is used to gradually increase the stimulation intensity to a desired therapeutic level. Between titration sessions one or more parameters, such as, for example, an acclimation interval, may be adjusted based on the patient's response to the stimulation. This personalized titration process can minimize the amount of time required to complete titration so as to begin delivery of the stimulation at therapeutically desirable levels.
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公开(公告)号:US11666760B2
公开(公告)日:2023-06-06
申请号:US17216251
申请日:2021-03-29
Applicant: LivaNova USA, Inc.
Inventor: Shivkumar Sabesan , Steven E. Maschino
IPC: A61N1/36
CPC classification number: A61N1/36064 , A61N1/36053 , A61N1/36139 , A61N1/36178
Abstract: A method includes applying, by an implantable medical device (IMD), stimulation to a cranial nerve of a patient responsive to a determination that a level of synchrony between neural activity of one or more regions of an autonomic nervous system of the patient and one or more regions of a central nervous system of the patient falls below a first threshold and discontinuing the application of stimulation by the IMD when the level of synchrony exceeds a second threshold.
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公开(公告)号:US20230126576A1
公开(公告)日:2023-04-27
申请号:US17508539
申请日:2021-10-22
Applicant: LivaNova USA, Inc.
Inventor: Gerrard Merrill Carlson
IPC: A61N1/36
Abstract: A seizure detection system comprises a sensor and a control system. The sensor is configured to detect acceleration data associated with a patient’s movements. The control system is programmed to monitor, via the sensor, the acceleration data to detect a seizure precursor event. The control system is further programmed to, upon detection of the seizure precursor event, perform a frequency analysis of the acceleration data to identify a frequency of the patient’s movements. The control system is further programmed to determine that the patient is experiencing a seizure event based on the frequency of the patient’s movements.
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公开(公告)号:US11633600B2
公开(公告)日:2023-04-25
申请号:US17136804
申请日:2020-12-29
Applicant: LivaNova USA, Inc.
Inventor: Imad Libbus , Bruce KenKnight , Scott Stubbs , Scott Mazar
IPC: A61N1/36
Abstract: A neurostimulation system comprises a sensor and a control system. The sensor is configured to detect a cardiac physiological measure of a patient. The control system is programmed to monitor, via the sensor, the cardiac physiological measure during the treatment. The control system is further programmed to detect a change in the cardiac physiological measure during the treatment. The control system is further programmed to determine, based on the detected change in the cardiac physiological measure, a first transition time in a duty cycle of a neurostimulation signal delivered to the patient where the neurostimulation signal transitions between a stimulation OFF period and a stimulation ON period.
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公开(公告)号:US11554263B2
公开(公告)日:2023-01-17
申请号:US16422746
申请日:2019-05-24
Applicant: LivaNova USA, Inc.
Inventor: Imad Libbus , Bruce D. Nearing , Badri Amurthur , Bruce H. KenKnight , Richard L. Verrier
Abstract: An implantable vagus nerve stimulation (VNS) system includes a sensor configured to measure ECG data for a patient, a stimulation subsystem configured to deliver VNS to the patient, and a control system configured to perform a heart rate variability analysis with the ECG data. In some aspects, performing the heart rate variability analysis includes measuring R-R intervals between successive R-waves for the ECG data measured during a stimulation period and a baseline period, plotting each R-R interval against an immediately preceding R-R interval for each of the stimulation period and the baseline period, and determining at least one of a standard deviation from an axis of a line perpendicular to an identity line for each of the stimulation period plot and the baseline period plot or a centroid of each of the stimulation period plot and the baseline period plot.
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公开(公告)号:US11529514B2
公开(公告)日:2022-12-20
申请号:US15918519
申请日:2018-03-12
Applicant: LivaNova USA, Inc.
Inventor: Stephen L. Bolea , Thomas B. Hoegh , Brian D. Kuhnley , Dale G. Suilmann , Bruce J. Persson , John P. Beck , Sidney F. Hauschild , Wondimeneh Tesfayesus , Jason J. Skubitz , Mark R. Bosshard , Daniel A. Parrish , Robert E. Atkinson
Abstract: Devices, systems and methods of neurostimulation for treating obstructive sleep apnea. The system is adapted to send an electrical signal from an implanted neurostimulator through a stimulation lead to a patient's nerve at an appropriate phase of the respiratory cycle based on input from a respiration sensing lead. External components are adapted for wireless communication with the neurostimulator. The neurostimulator is adapted to deliver therapeutic stimulation based on inputs.
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公开(公告)号:US11433237B2
公开(公告)日:2022-09-06
申请号:US16711309
申请日:2019-12-11
Applicant: LivaNova USA, Inc.
Inventor: Eric Lovett
IPC: A61N1/36
Abstract: The present disclosure relates to a method for modulating the nervous system in order to reduce inflammation. The method includes delivering a vagus nerve stimulation (VNS) therapy to a vagus nerve of a patient for the treatment of inflammation according to a first set of parameters. The method further includes delivering a secondary nerve stimulation (SNS) therapy to a secondary nerve of the patient for the treatment of a sleep disorder according to a second set of parameters different from the first set of parameters.
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