公开(公告)号：US20150246034A1

公开(公告)日：2015-09-03

申请号：US14659819

申请日：2015-03-17

申请人： MALLINCKRODT LLC

发明人： Krishna Devarakonda ,  Michael J. Giuliani ,  Vishal K. Gupta ,  Ralph A. Heasley ,  Susan Shelby

IPC分类号： A61K31/485 ,  A61K9/20 ,  A61K31/167

CPC分类号： A61K31/485 ,  A61K9/0053 ,  A61K9/2013 ,  A61K9/2031 ,  A61K9/2054 ,  A61K9/2086 ,  A61K9/209 ,  A61K31/167 ,  A61K47/10 ,  A61K2300/00

摘要： The present disclosure provides extended release pharmaceutical compositions comprising oxycodone and acetaminophen that produce a quick initial onset of analgesia, yet, maintain analgesia for about 12 hours after administration of the composition to a subject in need thereof. The pharmaceutical compositions disclosed herein also reduce the levels of acetaminophen in a subject's blood near the end of the dosing interval because the acetaminophen released by the pharmaceutical composition is being eliminated by a subject's body faster than it is being absorbed.

摘要翻译： 本公开内容提供了包含羟考酮和对乙酰氨基酚的延长释放药物组合物，其产生快速起始镇痛，然而，在将组合物施用于有需要的受试者后，维持止痛约12小时。 本文公开的药物组合物还降低了在给药间隔结束时受试者血液中的对乙酰氨基酚的水平，因为药物组合物释放的对乙酰氨基酚被受试者的身体比被吸收更快地消除。

公开(公告)号：US08790694B2

公开(公告)日：2014-07-29

申请号：US14132500

申请日：2013-12-18

申请人： Mallinckrodt LLC

发明人： Krishna R. Devarakonda ,  Michael J. Giuliani ,  Vishal K. Gupta ,  Ralph A. Heasley ,  Susan Shelby

IPC分类号： A61K31/485 ,  A61K31/167

CPC分类号： A61K9/2031 ,  A61K9/0065 ,  A61K9/209 ,  A61K31/167 ,  A61K31/485 ,  A61K47/34 ,  A61K2300/00

摘要： The present disclosure provides extended release pharmaceutical compositions comprising an opioid and an additional active pharmaceutical ingredient, wherein the composition exhibits gastric retentive properties which are achieved by a combination of a physical property of the composition and release of the opioid, wherein upon administration to a subject, the composition has at least one pharmacokinetic parameter that differs by less than about 30% when the subject is in a fasted state as compared to a fed state.

摘要翻译： 本公开提供了包含阿片样物质和另外的活性药物成分的延长释放药物组合物，其中所述组合物显示出通过组合物的物理性质和阿片样物质的释放的组合来实现的胃保持性质，其中在施用于受试者 当与进食状态相比，当受试者处于禁食状态时，该组合物具有至少一个药代动力学参数差异小于约30％。

公开(公告)号：US20140170217A1

公开(公告)日：2014-06-19

申请号：US14109052

申请日：2013-12-17

申请人： MALLINCKRODT LLC

发明人： Krishna R. Devarakonda ,  Michael J. Giuliani ,  Vishal K. Gupta ,  Ralph A. Heasley ,  Susan Shelby

IPC分类号： A61K9/24 ,  A61K31/167 ,  A61K31/485

CPC分类号： A61K31/485 ,  A61K9/0053 ,  A61K9/2013 ,  A61K9/2031 ,  A61K9/2054 ,  A61K9/2086 ,  A61K9/209 ,  A61K31/167 ,  A61K47/10 ,  A61K2300/00

摘要： The present disclosure provides an extended release pharmaceutical composition comprising oxycodone and acetaminophen that provides a rapid onset of analgesia, and reduced levels of acetaminophen near the end of the dosing interval. Also provided are methods for reducing the risk of acetaminophen-induced hepatic damage in a subject being treated with an acetaminophen containing composition, as well as methods for treating pain in a subject in need thereof.

摘要翻译： 本公开提供了包含羟考酮和对乙酰氨基酚的延长释放药物组合物，其提供了止痛剂的快速开始，并且在给药间隔结束时附近降低了对乙酰氨基酚的水平。 还提供了降低用含对乙酰氨基酚组合物治疗的受试者中对乙酰氨基酚诱发的肝损伤风险的方法，以及用于治疗有需要的受试者的疼痛的方法。