公开(公告)号：US20210002194A1

公开(公告)日：2021-01-07

申请号：US16848430

申请日：2020-04-14

Applicant: Genomatica, Inc.

Inventor： Warren Clark ,  Michael Japs ,  Mark J. Burk

IPC: C07C29/76 ,  C12P7/18

Abstract: A process of isolating 1,4-butanediol (1,4-BDO) from a fermentation broth includes separating a liquid fraction enriched in 1,4-BDO from a solid fraction comprising cells, removing water from said liquid fraction, removing salts from said liquid fraction, and purifying 1,4-BDO. A process for producing 1,4-BDO includes culturing a 1,4-BDO-producing microorganism in a fermentor for a sufficient period of time to produce 1,4-BDO. The 1,4-BDO-producing microorganism includes a microorganism having a 1,4-BDO pathway having one or more exogenous genes encoding a 1,4-BDO pathway enzyme and/or one or more gene disruptions. The process for producing 1,4-BDO further includes isolating 1,4-BDO.

公开(公告)号：US20190177255A1

公开(公告)日：2019-06-13

申请号：US16216965

申请日：2018-12-11

Applicant: Genomatica, Inc.

Inventor： SVB Janardhan Garikipati ,  Michael Japs ,  Ishmael M. Sonico

IPC: C07C29/80 ,  B01D3/14 ,  B01D3/00 ,  C12P7/18 ,  C08G65/34 ,  C08G18/32 ,  C07C31/20

Abstract: A process of purifying 1,4-butanediol (1,4-BDO) from a fermentation broth including separating solid materials, salts and water, and subjecting the resulting material to a two, three or four column distillation system, that can include a wiped film evaporator to produce a purified 1,4-butanediol.

公开(公告)号：US20190112247A1

公开(公告)日：2019-04-18

申请号：US15975630

申请日：2018-05-09

Applicant: Genomatica, Inc.

Inventor： Warren Clark ,  Michael Japs ,  Mark J. Burk

IPC: C07C29/76 ,  C12P7/18

Abstract: A process of isolating 1,4-butanediol (1,4-BDO) from a fermentation broth includes separating a liquid fraction enriched in 1,4-BDO from a solid fraction comprising cells, removing water from said liquid fraction, removing salts from said liquid fraction, and purifying 1,4-BDO. A process for producing 1,4-BDO includes culturing a 1,4-BDO-producing microorganism in a fermentor for a sufficient period of time to produce 1,4-BDO. The 1,4-BDO-producing microorganism includes a microorganism having a 1,4-BDO pathway having one or more exogenous genes encoding a 1,4-BDO pathway enzyme and/or one or more gene disruptions. The process for producing 1,4-BDO further includes isolating 1,4-BDO.

公开(公告)号：US09873652B2

公开(公告)日：2018-01-23

申请号：US14776517

申请日：2014-03-14

Applicant: Genomatica, Inc.

Inventor： SVB Janardhan Garikipati ,  Michael Japs ,  Ishmael M. Sonico

IPC: C07C29/80 ,  C07C29/74 ,  B01D3/14 ,  C07C29/90 ,  B01D1/22 ,  B01D3/00 ,  C07C29/00 ,  C07C31/20 ,  C12P7/18

CPC classification number: C07C29/80 ,  B01D1/22 ,  B01D3/002 ,  B01D3/143 ,  B01D3/145 ,  C07C29/00 ,  C07C29/74 ,  C07C29/90 ,  C07C31/207 ,  C12P7/18 ,  C07C33/046

Abstract: A process of purifying 1,4-butanediol (1,4-BDO) from a fermentation broth including separating solid materials, salts and water, and subjecting the resulting material to a two, three or four column distillation system, that can include a wiped film evaporator to produce a purified 1,4-butanediol product.

公开(公告)号：US20210002195A1

公开(公告)日：2021-01-07

申请号：US16799743

申请日：2020-02-24

Applicant: Genomatica, Inc.

Inventor： SVB Janardhan Garikipati ,  Michael Japs ,  Ishmael M. Sonico

IPC: C07C29/80 ,  C12P7/18 ,  C08G18/32 ,  C08G65/34 ,  B01D3/00 ,  B01D3/14 ,  C07C31/20

Abstract: A process of purifying 1,4-butanediol (1,4-BDO) from a fermentation broth including separating solid materials, salts and water, and subjecting the resulting material to a two, three or four column distillation system, that can include a wiped film evaporator to produce a purified 1,4-butanediol.

公开(公告)号：US20170369913A1

公开(公告)日：2017-12-28

申请号：US15538448

申请日：2015-12-22

Applicant: Genomatica, Inc.

Inventor： Lauri H. Suominen ,  Connor J. Galleher ,  Michael Japs ,  Mark J. Burk ,  Cara Tracewell

IPC: C12P13/00 ,  C12N11/16 ,  C12N9/96 ,  C12N9/88 ,  C12N1/20 ,  C12N15/52 ,  C12N1/02

Abstract: Provided is a method of producing and isolating a diamine produced by microbial fermentation that minimizes undesirable salt formation to provide a lower cost process.

公开(公告)号：US20140275465A1

公开(公告)日：2014-09-18

申请号：US14211863

申请日：2014-03-14

Applicant: Genomatica, Inc.

Inventor： SVB Janardhan Garikipati ,  Michael Japs ,  Ishmael M. Sonico

IPC: C07C29/80 ,  C12P7/18 ,  C08G65/26 ,  C08G18/32 ,  C08G63/16 ,  C08G63/06 ,  C07C29/90 ,  C07C31/20

CPC classification number: C07C29/80 ,  B01D3/002 ,  B01D3/143 ,  B01D3/145 ,  C07C31/207 ,  C08G18/3206 ,  C08G65/34 ,  C12P7/18

Abstract: A process of purifying 1,4-butanediol (1,4-BDO) from a fermentation broth including separating solid materials, salts and water, and subjecting the resulting material to a two, three or four column distillation system, that can include a wiped film evaporator to produce a purified 1,4-butanediol.

Abstract translation: 从发酵液中纯化1,4-丁二醇（1,4-BDO）的方法，包括分离固体物质，盐和水，并将所得物质进行二，三或四列蒸馏系统，其可以包括擦拭 薄膜蒸发器以产生纯化的1,4-丁二醇。