公开(公告)号：US08895067B2

公开(公告)日：2014-11-25

申请号：US11568455

申请日：2005-04-28

申请人： Juan Manuel Irache Garreta ,  Carlos Gamazo De La Rasilla ,  Maria Luisa Sanz Larruga ,  Marta Ferrer Puga ,  Beatriz San Román Aberasturi ,  Hesham H. A. Salman ,  Sara Gómez Martinez ,  Javier Ochoa Rep{dot over (a)}raz

发明人： Juan Manuel Irache Garreta ,  Carlos Gamazo De La Rasilla ,  Maria Luisa Sanz Larruga ,  Marta Ferrer Puga ,  Beatriz San Román Aberasturi ,  Hesham H. A. Salman ,  Sara Gómez Martinez ,  Javier Ochoa Rep{dot over (a)}raz

IPC分类号： A61K9/14 ,  A61K36/00 ,  A61K36/06 ,  A61K39/112 ,  A61K39/39 ,  B82Y5/00 ,  A61K51/12 ,  A61K39/00

CPC分类号： A61K36/00 ,  A61K9/14 ,  A61K36/06 ,  A61K39/0275 ,  A61K39/39 ,  A61K51/1244 ,  A61K2039/55511 ,  A61K2039/55555 ,  A61K2039/55572 ,  A61K2039/55594 ,  B82Y5/00 ,  Y02A50/482 ,  Y10S977/773 ,  A61K2300/00

摘要： The composition for stimulating an immune response in a subject comprises methyl vinyl ether and maleic anhydride copolymer-based nanoparticles. Said nanoparticles may further contain an allergen or an antigen and/or an immunostimulating agent, which may be contained inside said nanoparticles and/or at least partially coating the surface of said nanoparticles, and optionally a cross-linking agent. The immune response stimulating composition is useful as an adjuvant in immunotherapy and vaccines.

摘要翻译： 用于刺激受试者的免疫应答的组合物包括甲基乙烯基醚和基于马来酸酐共聚物的纳米颗粒。 所述纳米颗粒可以进一步含有变应原或抗原和/或免疫刺激剂，其可以包含在所述纳米颗粒内部和/或至少部分地涂覆所述纳米颗粒的表面和任选的交联剂。 免疫应答刺激组合物可用作免疫治疗和疫苗中的佐剂。

公开(公告)号：US20070207965A1

公开(公告)日：2007-09-06

申请号：US11365764

申请日：2006-03-01

申请人： Francisco Borras Cuesta ,  Javier Dotor De Las Herrerias ,  Juan Manuel Irache Garreta ,  Fernando Martinez Galan ,  Jesus Prieto Valtuena

发明人： Francisco Borras Cuesta ,  Javier Dotor De Las Herrerias ,  Juan Manuel Irache Garreta ,  Fernando Martinez Galan ,  Jesus Prieto Valtuena

IPC分类号： A61K38/10

CPC分类号： A61K38/10 ,  Y10S514/937

摘要： A Method for the treatment of skin fibrosis with a peptide that inhibits TGF-β, and suitable compositions for its administration. The method includes in particular, the use of peptide P144, a compound that is a known inhibitor of TGF-β, for the treatment of skin fibrosis by topical application. The method is shown effective in an animal model of bleomycin-induced skin sclerosis, to a reduction both of the skin fibrosis and of the content of soluble collagen, without any signs of systemic toxicity being detected. This shows that P144 is effective for topical application in mammals for treating fibrotic skin diseases and pathological scarring of the skin. For the administration of this peptide, stable compositions are also supplied, with pleasant appearance without being greasy, with good spreading characteristics and with a viscosity that permits it to be processed easily in industrial plant, and which are suitable for administering the peptide to humans.

摘要翻译： 用抑制TGF-β的肽治疗皮肤纤维化的方法及其给药的合适组合物。 该方法特别包括使用肽P144，一种已知的TGF-β抑制剂的化合物，用于通过局部应用治疗皮肤纤维化。 该方法显示在博来霉素诱导的皮肤硬化的动物模型中有效，可以减少皮肤纤维化和可溶性胶原含量，而没有检测到任何全身毒性迹象。 这表明P144在哺乳动物中用于治疗纤维化皮肤疾病和皮肤病理性瘢痕形成的局部应用是有效的。 对于该肽的给药，还提供了稳定的组合物，具有愉悦的外观，而不油腻，具有良好的铺展特性，并且具有允许其在工业植物中容易加工的粘度，并且适合于向人体施用肽。