公开(公告)号：US20240358783A1

公开(公告)日：2024-10-31

申请号：US18767841

申请日：2024-07-09

申请人： LYFE CHNG, LLC

发明人： Frank KOCHINKE ,  Chad CONNER ,  Bryan ARRAYALES

IPC分类号： A61K36/185 ,  A61K9/70 ,  A61K31/375 ,  A61K31/404 ,  A61K36/06

CPC分类号： A61K36/185 ,  A61K9/7038 ,  A61K31/375 ,  A61K31/404 ,  A61K36/06

摘要： A method and drug delivery system are provided for transdermally administering a psychedelic active agent to a subject to provide continuous microdose plasma levels of the active agent or a metabolite thereof during an extended drug delivery time period. The transdermal drug delivery system comprises a drug reservoir that houses a formulation containing the active agent, a combination of a solubilizer-type permeation enhancer and a plasticizer-type permeation enhancer, and a pH stabilizing agent. The pH stabilizing agent brings the pH of the formulation, at the system-skin interface, and/or within the skin as the active agent is transported across the skin from the skin surface to the bloodstream, to within 25% of the pKa of the active agent. Formulations and methods of use are also provided.

公开(公告)号：US12064449B2

公开(公告)日：2024-08-20

申请号：US16972090

申请日：2019-06-04

申请人： Sidero Bioscience, LLC

发明人： Darren Wolfe ,  James Connor

IPC分类号： A61K33/26 ,  A23L33/00 ,  A23L33/14 ,  A23L33/165 ,  A23L33/17 ,  A61K35/74 ,  A61K36/06

CPC分类号： A61K33/26 ,  A23L33/14 ,  A23L33/165 ,  A23L33/17 ,  A23L33/30 ,  A61K35/74 ,  A61K36/06

摘要： Disclosed is a composition comprising a microbe expressing ferritin. The composition also comprises elemental iron in an amount of at least 3% by weight on a dry matter basis of the microbe expressing ferritin and the elemental iron. Also disclosed are ingestibles, dietary supplements, and pharmaceutical compositions comprising the composition. Also disclosed are methods for treating a subject comprising administering the composition to the subject. Also disclosed are methods of altering the composition of the gut bacterial microbiome in a subject, the method comprising administering the composition to the subject.

公开(公告)号：US20240252515A1

公开(公告)日：2024-08-01

申请号：US18417621

申请日：2024-01-19

申请人： ARJIL BIOTECH HOLDING COMPANY LIMITED

发明人： Yeh B WU ,  Jir-Mehng LO ,  Hui-Ju LIANG ,  Pei-Hsin LIN ,  Kuo-Kuei HUANG

IPC分类号： A61K31/575 ,  A61K36/06 ,  A61P1/16 ,  A61P11/00 ,  A61P13/12

CPC分类号： A61K31/575 ,  A61K36/06 ,  A61P1/16 ,  A61P11/00 ,  A61P13/12 ,  A61K2236/33

摘要： The present invention relates to a method of preventing or treating a fibrotic condition, comprising administering an effective amount of composition to a subject in need thereof; wherein the composition comprises triterpenes extracted from antrodia camphorate or Anisomeles indica.

公开(公告)号：US20240123006A1

公开(公告)日：2024-04-18

申请号：US18546238

申请日：2022-02-15

申请人： DSM IP ASSETS B.V.

发明人： Joshua CLAYPOOL ,  Aaron COWIESON ,  Kevin FREEMAN ,  Ghislain SCHYNS

IPC分类号： A61K36/06 ,  A23K10/30 ,  A23K20/158 ,  A23K20/163 ,  A23K50/75 ,  A61K31/05 ,  A61K31/4525 ,  A61P1/14

CPC分类号： A61K36/06 ,  A23K10/30 ,  A23K20/158 ,  A23K20/163 ,  A23K50/75 ,  A61K31/05 ,  A61K31/4525 ,  A61P1/14

摘要： The present disclosure relates to methods of feeding animals by providing feed additives that modulate the gut microbiome improve the health and welfare of the animal. The present disclosure further relates to methods of modulating level of secondary metabolites present in the gastrointestinal tract of an animal. Such modulation includes, for example, modulating the level of tryptophan metabolism derivates.

公开(公告)号：US20240123005A1

公开(公告)日：2024-04-18

申请号：US18138101

申请日：2023-04-23

申请人： VCENNA Technology & Labs Inc.

发明人： Seyed Reza Etminan

IPC分类号： A61K36/06 ,  B01D11/02 ,  B01D36/00

CPC分类号： A61K36/06 ,  B01D11/0207 ,  B01D11/0257 ,  B01D11/0265 ,  B01D11/0288 ,  B01D36/00 ,  A61K2236/31

摘要： A system for extracting substances from a source material includes a chamber assembly, one or more ultrasonic transducers, and one or more convective mixing mechanisms. The chamber assembly defines a chamber. The chamber is configured to hold source material and a solvent such that at least a portion of the source material is immersed in the solvent. The one or more ultrasonic transducers are configured to produce ultrasonic waves that impinge on at least a portion of the portion of the source material in the solvent. The one or more mixers are configured to mix at least a portion of the source material.

公开(公告)号：US20240108640A1

公开(公告)日：2024-04-04

申请号：US18475724

申请日：2023-09-27

申请人： TURTLE BEAR HOLDINGS, LLC

发明人： Paul Edward STAMETS

IPC分类号： A61K31/661 ,  A61K9/08 ,  A61K31/05 ,  A61K31/352 ,  A61K31/4045 ,  A61K31/455 ,  A61K36/06 ,  A61K36/066 ,  A61K36/07 ,  A61K36/185 ,  A61K36/73 ,  A61P25/24

CPC分类号： A61K31/661 ,  A61K9/08 ,  A61K31/05 ,  A61K31/352 ,  A61K31/4045 ,  A61K31/455 ,  A61K36/06 ,  A61K36/066 ,  A61K36/07 ,  A61K36/185 ,  A61K36/73 ,  A61P25/24

摘要： Described herein are neurotrophic and nootropic compositions and methods for treating subjects with such compositions. In one aspect the composition comprises one or more tryptamines or in pure form or extracts from psilocybin containing mushrooms, or combinations thereof optionally combined with one or more phenethylamines or amphetamines in pure form or extracts from a plant or mushroom, or combinations thereof, optionally one or more erinacines or hericenones in pure form, extracts from Hericium mushroom species (e.g., H. erinaceus, H. coralloides, H. ramosum) or combinations thereof, optionally one or more cannabinoids in pure form or extracts from Cannabis sativa, Cannabis sativa, Cannabis indica, or Cannabis ruderalis, optionally, one or more adversive compounds, and optionally one or more pharmaceutically acceptable excipients.

公开(公告)号：US11910808B2

公开(公告)日：2024-02-27

申请号：US16920997

申请日：2020-07-06

申请人： Native Microbials, Inc.

发明人： Mallory Embree ,  Luke Picking ,  Grant Gogul ,  Janna Tarasova

IPC分类号： A23K10/18 ,  A23K50/10 ,  A23L33/135 ,  A61K35/74 ,  A61K35/741 ,  A61K35/742 ,  A61K36/06 ,  A61K36/062 ,  A61P15/04 ,  A61K36/064 ,  A23K40/35 ,  A61K9/00 ,  A23L31/10 ,  A61P31/04 ,  A61K39/02 ,  C12N1/14 ,  C12N1/20 ,  A23K20/158 ,  A23K20/163 ,  A23K20/28 ,  A23K10/30 ,  A23K10/37 ,  A61K35/748

CPC分类号： A23K10/18 ,  A23K10/30 ,  A23K10/37 ,  A23K20/158 ,  A23K20/163 ,  A23K20/28 ,  A23K40/35 ,  A23K50/10 ,  A23L31/10 ,  A23L33/135 ,  A61K9/0019 ,  A61K9/0053 ,  A61K35/74 ,  A61K35/741 ,  A61K35/742 ,  A61K36/06 ,  A61K36/062 ,  A61K36/064 ,  A61K39/02 ,  A61P15/04 ,  A61P31/04 ,  C12N1/14 ,  C12N1/20 ,  A61K35/748

摘要： The present disclosure provides compositions formulated for ruminants that comprise beneficial microbes. Particularly, the disclosure provides a composition comprising microorganisms with at least 97% sequence identity to any one of SEQ ID NOs: 1-60 and 2045-2107. Such compositions can be used for increasing milk production or improving milk compositional characteristics in ruminants.

公开(公告)号：US20240024395A1

公开(公告)日：2024-01-25

申请号：US18257420

申请日：2021-12-21

申请人： INTERVET INC.

发明人： Sietske Kooijman ,  Ruud Philip Antoon Maria Segers ,  Maarten Hendrik Witvliet

IPC分类号： A61K36/06 ,  A61K31/343 ,  A61K47/64 ,  A61P39/02

CPC分类号： A61K36/06 ,  A61K31/343 ,  A61K47/643 ,  A61K47/646 ,  A61P39/02 ,  A61K2039/552

摘要： The present invention pertains to the use of conjugated T-2 toxin (T2) in a method to protect an animal against T2 induced mycotoxicosis, in particular to protect against a decrease in average daily weight gain, intestinal damage, skin damage and snout damage, thus one or more of these signs of mycotoxicosis induced by T2 as a result of the ingestion of T2.

公开(公告)号：US11865151B2

公开(公告)日：2024-01-09

申请号：US16792178

申请日：2020-02-14

申请人： GUTSYBIO INC.

发明人： Genevieve Hansen

IPC分类号： A61K36/06 ,  C12N1/16 ,  A23L33/14 ,  A23L33/00 ,  A23L33/21

CPC分类号： A61K36/06 ,  A23L33/14 ,  A23L33/21 ,  A23L33/30 ,  C12N1/16 ,  A23V2002/00

摘要： The present invention provides method for treating a metabolic disorder, dietary intolerance, or malabsorption in a subject that causes an excess of a metabolite or a dietary substance, particularly a carbohydrate such as galactose or fructose, that the subject does not tolerate by administering an effective amount of an adaptively evolved yeast strain to the subject or to food that reduces the excess of the metabolite or dietary substance. Specifically, the invention is directed to methods for treating the metabolic disorder, such as galactosemia or fructosemia, in which an excess of the carbohydrate is present. The invention also provides isolated, adaptively evolved yeast strains that degrades a metabolite or dietary ingredient, such as galactose or fructose, and methods for preparing such isolated, adaptively evolved yeast strains.

公开(公告)号：US11833183B2

公开(公告)日：2023-12-05

申请号：US17585612

申请日：2022-01-27

申请人： TCI CO., LTD.

发明人： Yung-Hsiang Lin ,  Pei-Yi Wu

IPC分类号： A61K36/746 ,  A61P17/18 ,  A61P1/14 ,  A61K36/06 ,  A61K35/747 ,  A61P3/04 ,  A61K35/00

CPC分类号： A61K36/746 ,  A61K35/747 ,  A61K36/06 ,  A61P1/14 ,  A61P3/04 ,  A61P17/18 ,  A61K2035/115

摘要： A method for improving body shape and improving skin condition using a noni fruit ferment is provided, and the method includes: administrating a composition to a subject in need thereof. The composition includes an effective amount of noni fruit ferment. The noni fruit ferment is prepared by (a) mixing glucose and noni fruit with water for extraction, to obtain a noni fruit broth, and (b) fermenting the noni fruit broth with a plurality of bacteria strains. The bacteria strains include yeast, lactic acid bacteria, and acetic acid bacteria. In step (b), the noni fruit broth and the bacteria strains are irradiated with a red light source with a wavelength of 620 nm to 750 nm. In addition, the noni fruit ferment also has at least one of the following functions: removing free radicals, improving defecation status, and improving gastrointestinal motility.