公开(公告)号：US06392059B1

公开(公告)日：2002-05-21

申请号：US09856462

申请日：2001-06-07

申请人： Shiro Terashima ,  Masanori Takadoi ,  Akihiro Ishiwata ,  Tadashi Katoh

发明人： Shiro Terashima ,  Masanori Takadoi ,  Akihiro Ishiwata ,  Tadashi Katoh

IPC分类号： C07D30792

CPC分类号： C07D307/92 ,  C07D493/08

摘要： Intermediates for the preparation of himbacine exhibiting muscarinic M2 receptor antagonism, which are hydronaphtho[2,3-c]furan derivatives represented by general formula (1) or intermediates for the preparation thereof: wherein R1 is lower alkyl or aralky; R2 is hydrogen, lower alkyl or aralkyl; R3 and R4 together represent oxygen or methylene, or alternatively R4 is hydroxyl, lower alkoxy, aralkyloxy or lower acyloxy, with R3 being hydrogen; R5 and R6 together represent oxygen, or alternatively R6 is hydroxyl, lower alkxy, aralkyloxy or lower acyloxy, with R5 being hydrogen; and either of the broken lines is a single bond and the other thereof is a double bond, or alternatively both are single bonds.

摘要翻译： 用于制备表现出毒蕈碱M2受体拮抗作用的烟草碱的中间体，它们是由通式（1）表示的氢萘并[2,3-c]呋喃衍生物或其制备中间体：其中R1是低级烷基或芳烷基; R2是氢，低级烷基或芳烷基; R3和R4一起代表氧或亚甲基，或者R4是羟基，低级烷氧基，芳烷氧基或低级酰氧基，R3是氢; R5和R6一起代表氧，或者R6是羟基，低级烷氧基，芳烷氧基或低级酰氧基，R5是氢; 并且任一条虚线是单键，另一条是双键，或者两者都是单键。

公开(公告)号：US5300515A

公开(公告)日：1994-04-05

申请号：US824983

申请日：1992-01-24

申请人： Yasuo Takano ,  Masanori Takadoi ,  Takashi Hirayama ,  Atsuhiro Yamanishi

发明人： Yasuo Takano ,  Masanori Takadoi ,  Takashi Hirayama ,  Atsuhiro Yamanishi

IPC分类号： C07D211/60 ,  C07D401/04 ,  C07D401/14 ,  C07D417/04 ,  C07D211/68

CPC分类号： C07D401/04 ,  C07D211/60 ,  C07D401/14 ,  C07D417/04

摘要： Anti-dementia medicaments comprising a carbamic acid derivative or their pharmaceutically acceptable acid addition salts having an anti-amnesic activity as an active ingredient are provided. The carbamic acid derivatives are represented by a general formula (1) ##STR1## wherein Ar denotes an aromatic heterocyclic ring which may have at least one substituent or its benzene-condensed ring, or phenyl group which may have at least one substituent, R.sup.1 denotes hydrogen atom or lower alkyl group, R.sup.2 denotes lower alkyl group which may be substituted with halogen atom, phenyl group which may have at least one substituent, naphthyl group, or five- or six-membered heterocyclic ring and its benzene-condensed ring, X and Y, which may be the same or different, denote sulfur atom or oxygen atom.

摘要翻译： 提供了包含氨基甲酸衍生物或其药学上可接受的具有抗遗忘活性的酸加成盐作为有效成分的抗痴呆药物。 氨基甲酸衍生物由通式（1）（*化学结构*）（1）表示，其中Ar表示可具有至少一个取代基的芳族杂环或其苯稠合的环，或可以具有 至少一个取代基，R1表示氢原子或低级烷基，R2表示可被卤素原子取代的低级烷基，可具有至少一个取代基的苯基，萘基或五元或六元杂环， 苯稠合环，X和Y可以相同或不同，表示硫原子或氧原子。