公开(公告)号：US06392059B1

公开(公告)日：2002-05-21

申请号：US09856462

申请日：2001-06-07

申请人： Shiro Terashima ,  Masanori Takadoi ,  Akihiro Ishiwata ,  Tadashi Katoh

发明人： Shiro Terashima ,  Masanori Takadoi ,  Akihiro Ishiwata ,  Tadashi Katoh

IPC分类号： C07D30792

CPC分类号： C07D307/92 ,  C07D493/08

摘要： Intermediates for the preparation of himbacine exhibiting muscarinic M2 receptor antagonism, which are hydronaphtho[2,3-c]furan derivatives represented by general formula (1) or intermediates for the preparation thereof: wherein R1 is lower alkyl or aralky; R2 is hydrogen, lower alkyl or aralkyl; R3 and R4 together represent oxygen or methylene, or alternatively R4 is hydroxyl, lower alkoxy, aralkyloxy or lower acyloxy, with R3 being hydrogen; R5 and R6 together represent oxygen, or alternatively R6 is hydroxyl, lower alkxy, aralkyloxy or lower acyloxy, with R5 being hydrogen; and either of the broken lines is a single bond and the other thereof is a double bond, or alternatively both are single bonds.

摘要翻译： 用于制备表现出毒蕈碱M2受体拮抗作用的烟草碱的中间体，它们是由通式（1）表示的氢萘并[2,3-c]呋喃衍生物或其制备中间体：其中R1是低级烷基或芳烷基; R2是氢，低级烷基或芳烷基; R3和R4一起代表氧或亚甲基，或者R4是羟基，低级烷氧基，芳烷氧基或低级酰氧基，R3是氢; R5和R6一起代表氧，或者R6是羟基，低级烷氧基，芳烷氧基或低级酰氧基，R5是氢; 并且任一条虚线是单键，另一条是双键，或者两者都是单键。

公开(公告)号：US06380404B1

公开(公告)日：2002-04-30

申请号：US09806835

申请日：2001-05-29

申请人： Paul Nicholas Davey ,  Chi-Lam Tse

发明人： Paul Nicholas Davey ,  Chi-Lam Tse

IPC分类号： C07D30792

CPC分类号： C07D307/92

摘要： Norlabdane oxide, which is a well known fragrance material having ambergris-type odors, is prepared from 12-acetoxy-norlabdane oxide by a hydrogenation reaction.

摘要翻译： 通过氢化反应由12-乙酸基 - 正辛烷氧化物制备作为具有琥珀酸型气味的众所周知的香料的诺拉普丹氧化物。