公开(公告)号：US20180243333A1

公开(公告)日：2018-08-30

申请号：US15887469

申请日：2018-02-02

Applicant: McMaster University

Inventor： Eric Brown ,  Maya Farha ,  Craig MacNair ,  Jonathan Stokes

IPC: A61K33/00 ,  A61P31/04 ,  A61P31/10 ,  A61P31/18 ,  A61P31/16 ,  A61P31/22 ,  A61P33/02

CPC classification number: A61K33/00 ,  A61K31/431 ,  A61K2300/00 ,  A61P31/04 ,  A61P31/10 ,  A61P31/16 ,  A61P31/18 ,  A61P31/22 ,  A61P33/02 ,  Y02A50/402 ,  Y02A50/463 ,  Y02A50/475 ,  Y02A50/478 ,  Y02A50/481

Abstract: Provided herein are methods and compositions for modulating a microorganism's response to an antimicrobial agent. In one embodiment, the method comprises contacting the microorganism with an antimicrobial agent and bicarbonate. In one embodiment, provided herein are methods for treating a microbial infection comprising administering to a subject in need an effective amount of (i) bicarbonate and (ii) an antimicrobial agent. Also provided herein are methods of screening for antimicrobial compounds.