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公开(公告)号:US20210220393A1
公开(公告)日:2021-07-22
申请号:US17157118
申请日:2021-01-25
Applicant: McMaster University
Inventor: Eric Brown , Maya Farha , Craig MacNair , Jonathan Stokes
Abstract: Provided herein are methods and compositions for modulating a microorganism's response to an antimicrobial agent. In one embodiment, the method comprises contacting the microorganism with an antimicrobial agent and bicarbonate. In one embodiment, provided herein are methods for treating a microbial infection comprising administering to a subject in need an effective amount of (i) bicarbonate and (ii) an antimicrobial agent. Also provided herein are methods of screening for antimicrobial compounds.
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公开(公告)号:US10940163B2
公开(公告)日:2021-03-09
申请号:US15887469
申请日:2018-02-02
Applicant: McMaster University
Inventor: Eric Brown , Maya Farha , Craig MacNair , Jonathan Stokes
Abstract: Provided herein are methods and compositions for modulating a microorganism's response to an antimicrobial agent. In one embodiment, the method comprises contacting the microorganism with an antimicrobial agent and bicarbonate. In one embodiment, provided herein are methods for treating a microbial infection comprising administering to a subject in need an effective amount of (i) bicarbonate and (ii) an antimicrobial agent. Also provided herein are methods of screening for antimicrobial compounds.
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公开(公告)号:US20240033285A1
公开(公告)日:2024-02-01
申请号:US18476828
申请日:2023-09-28
Applicant: McMaster University
Inventor: Eric Brown , Maya Farha , Craig MacNair , Jonathan Stokes
CPC classification number: A61K33/00 , A61P31/04 , A61P31/10 , A61P31/18 , A61P31/22 , A61P33/02 , A61P31/16 , A61K31/431
Abstract: Provided herein are methods and compositions for modulating a microorganism's response to an antimicrobial agent. In one embodiment, the method comprises contacting the microorganism with an antimicrobial agent and bicarbonate. In one embodiment, provided herein are methods for treating a microbial infection comprising administering to a subject in need an effective amount of (i) bicarbonate and (ii) an antimicrobial agent. Also provided herein are methods of screening for antimicrobial compounds.
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公开(公告)号:US11779595B2
公开(公告)日:2023-10-10
申请号:US17157118
申请日:2021-01-25
Applicant: McMaster University
Inventor: Eric Brown , Maya Farha , Craig MacNair , Jonathan Stokes
CPC classification number: A61K33/00 , A61P31/04 , A61P31/10 , A61P31/16 , A61P31/18 , A61P31/22 , A61P33/02 , A61K31/431 , A61K2300/00 , Y02A50/30
Abstract: Provided herein are methods and compositions for modulating a microorganism's response to an antimicrobial agent. In one embodiment, the method comprises contacting the microorganism with an antimicrobial agent and bicarbonate. In one embodiment, provided herein are methods for treating a microbial infection comprising administering to a subject in need an effective amount of (i) bicarbonate and (ii) an antimicrobial agent. Also provided herein are methods of screening for antimicrobial compounds.
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公开(公告)号:US20180243333A1
公开(公告)日:2018-08-30
申请号:US15887469
申请日:2018-02-02
Applicant: McMaster University
Inventor: Eric Brown , Maya Farha , Craig MacNair , Jonathan Stokes
CPC classification number: A61K33/00 , A61K31/431 , A61K2300/00 , A61P31/04 , A61P31/10 , A61P31/16 , A61P31/18 , A61P31/22 , A61P33/02 , Y02A50/402 , Y02A50/463 , Y02A50/475 , Y02A50/478 , Y02A50/481
Abstract: Provided herein are methods and compositions for modulating a microorganism's response to an antimicrobial agent. In one embodiment, the method comprises contacting the microorganism with an antimicrobial agent and bicarbonate. In one embodiment, provided herein are methods for treating a microbial infection comprising administering to a subject in need an effective amount of (i) bicarbonate and (ii) an antimicrobial agent. Also provided herein are methods of screening for antimicrobial compounds.
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