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11.发明授权Biphenyl compounds useful in the treatment or prevention of cardiovascular disorders 有权用于治疗或预防心血管疾病的联苯化合物公开(公告)号：US07998988B2
公开(公告)日：2011-08-16
申请号：US12083760
申请日：2006-10-09
申请人： Stephan Bartel , Michael Hahn , Wahed Ahmed Moradi , Klaus Münter , Thomas Rölle , Johannes-Peter Stasch , Karl-Heinz Schlemmer , Frank Wunder
发明人： Stephan Bartel , Michael Hahn , Wahed Ahmed Moradi , Klaus Münter , Thomas Rölle , Johannes-Peter Stasch , Karl-Heinz Schlemmer , Frank Wunder
IPC分类号： A01N43/82
CPC分类号： C07D271/07 , C07D249/12 , C07D249/14 , C07D271/113
摘要： The invention relates to biphenyl compounds of formula (I): wherein U, V and W together form a group of the formula *—CH═CH—CH
摘要翻译： 本发明涉及式（I）的联苯化合物：其中U，V和W一起形成式* -CH = CH-CH <，* -CH2-CH2-CH <或* -CH2-CH2-N ，其中*表示与苯环的连接点; A是O或CH2; 和D，E，X，Y，Z，R1，R2，o，n和p如说明书中所定义。 本发明还涉及化合物的化合物的药物组合物。 本发明的化合物和药物组合物可用于治疗或预防心血管疾病。
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12.发明申请Heterocyclic compounds with carboxyl isostere groups and their use for the treatment of cardiovascular diseases 有权具有羧基等排基团的杂环化合物及其用于治疗心血管疾病的用途公开(公告)号：US20090227640A1
公开(公告)日：2009-09-10
申请号：US12083760
申请日：2006-10-09
申请人： Stephan Bartel , Michael Hahn , Wahed Ahmed Moradi , Klaus Münter , Thomas Rölle , Johannes-Peter Stasch , Karl-Heinz Schlemmer , Frank Wunder
发明人： Stephan Bartel , Michael Hahn , Wahed Ahmed Moradi , Klaus Münter , Thomas Rölle , Johannes-Peter Stasch , Karl-Heinz Schlemmer , Frank Wunder
IPC分类号： A61K31/4245 , A61K31/4196 , C07D271/07 , C07D249/12
CPC分类号： C07D271/07 , C07D249/12 , C07D249/14 , C07D271/113
摘要： The present application relates to novel heterocyclic compounds, processes for their preparation, their use for the treatment and/or prophylaxis of diseases, and their use for producing medicaments for the treatment and/or prophylaxis of diseases, especially for the treatment and/or prevention of cardiovascular disorders.
摘要翻译： 本申请涉及新型杂环化合物，其制备方法，其用于治疗和/或预防疾病的用途及其用于治疗和/或预防疾病尤其是用于治疗和/或预防的药物的用途 的心血管疾病。
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13.发明授权公开(公告)号：US08329716B2
公开(公告)日：2012-12-11
申请号：US11547975
申请日：2005-03-30
申请人： Hartmut Schirok , Martin Radtke , Joachim Mittendorf , Raimund Kast , Johannes-Peter Stasch , Mark Jean Gnoth , Klaus Münter , Dieter Lang , Santiago Figueroa Perez , Michael Thutewohl , Samir Bennabi , Heimo Ehmke
发明人： Hartmut Schirok , Martin Radtke , Joachim Mittendorf , Raimund Kast , Johannes-Peter Stasch , Mark Jean Gnoth , Klaus Münter , Dieter Lang , Santiago Figueroa Perez , Michael Thutewohl , Samir Bennabi , Heimo Ehmke
IPC分类号： C07D471/04 , A61K31/437
CPC分类号： C07D471/04
摘要： The invention relates to hetaryloxy-substituted phenylaminopyrimidines, to a process for their preparation and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases in humans and animals, in particular cardiovascular disorders.
摘要翻译： 本发明涉及苯甲酰氧基取代的苯基氨基嘧啶，其制备方法及其用于制备用于治疗和/或预防人和动物疾病，特别是心血管疾病的药物。
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公开(公告)号：US07723347B2
公开(公告)日：2010-05-25
申请号：US11587630
申请日：2005-04-14
申请人： Hartmut Schirok , Johannes-Peter Stasch , Raimund Kast , Klaus Münter , Marc Jean Gnoth , Santiago Figureoa Perez , Michael Thutewohl , Samir Bennabi , Dieter Lang , Joachim Mittendorf , Martin Radtke , Heimo Ehmke
发明人： Hartmut Schirok , Johannes-Peter Stasch , Raimund Kast , Klaus Münter , Marc Jean Gnoth , Santiago Figureoa Perez , Michael Thutewohl , Samir Bennabi , Dieter Lang , Joachim Mittendorf , Martin Radtke , Heimo Ehmke
IPC分类号： C07D471/04 , A61K31/437
CPC分类号： C07D471/04
摘要： The invention relates to substituted phenylaminopyrimidines, to a process for their preparation and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases in humans and animals, in particular cardiovascular disorders.
摘要翻译： 本发明涉及取代的苯基氨基嘧啶，其制备方法及其用于制备用于治疗和/或预防人和动物疾病，特别是心血管疾病的药物。
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15.发明授权Heteroaryloxy-substituted phenylaminopyrimidines as rho-kinase inhibitors 失效杂环氧基取代的苯基氨基嘧啶作为rho激酶抑制剂公开(公告)号：US07737153B2
公开(公告)日：2010-06-15
申请号：US10531889
申请日：2003-10-16
申请人： Achim Feurer , Samir Bennabi , Heike Heckroth , Hartmut Schirok , Joachim Mittendorf , Raimund Kast , Johannes-Peter Stasch , Jean Mark Gnoth , Klaus Münter , Dieter Lang , Santiago Figueroa Perez , Heimo Ehmke
发明人： Achim Feurer , Samir Bennabi , Heike Heckroth , Hartmut Schirok , Joachim Mittendorf , Raimund Kast , Johannes-Peter Stasch , Jean Mark Gnoth , Klaus Münter , Dieter Lang , Santiago Figueroa Perez , Heimo Ehmke
IPC分类号： A01N43/90 , A61K31/519 , A61K31/505 , C07D487/00 , C07D239/02 , C07D401/00 , C07D403/00 , C07D405/00 , C07D409/00 , C07D411/00 , C07D413/00 , C07D417/00 , C07D419/00
CPC分类号： C07D401/14 , C07D403/12 , C07D471/04
摘要： The invention relates to heteroaryloxy-substituted phenylaminopyrimidines, to methods for the production thereof, and to the use of the same for producing medicaments for the treatment and/or prophylaxis of diseases, especially cardiovascular diseases. The inventive compounds inhibit Rho-Kinase.
摘要翻译： 本发明涉及杂芳氧基取代的苯基氨基嘧啶，其制备方法及其用于制备用于治疗和/或预防疾病，特别是心血管疾病的药物。 本发明化合物抑制Rho-激酶。
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公开(公告)号：US08487111B2
公开(公告)日：2013-07-16
申请号：US12665718
申请日：2008-06-07
申请人： Swen Allerheiligen , Marcus Bauser , Hartmut Schirok , Ulrich Rester , Stefan Heitmeier , Christoph Gerdes , Georges Von Degenfeld , Elke Dittrich-Wengenroth , Uwe Saatmann , Julia Straβburger , Klaus Münter , Mark Jean Gnoth , Dieter Lang
发明人： Swen Allerheiligen , Marcus Bauser , Hartmut Schirok , Ulrich Rester , Stefan Heitmeier , Christoph Gerdes , Georges Von Degenfeld , Elke Dittrich-Wengenroth , Uwe Saatmann , Julia Straβburger , Klaus Münter , Mark Jean Gnoth , Dieter Lang
IPC分类号： A61K31/44 , C07D413/00
CPC分类号： C07D413/14
摘要： The invention relates to novel substituted oxazolidinones, to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular of thromboembolic disorders.
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公开(公告)号：US07173037B2
公开(公告)日：2007-02-06
申请号：US10513869
申请日：2003-04-25
申请人： Cristina Alonso-Alija , Erwin Bischoff , Klaus Münter , Johannes-Peter Stasch , Elke Stahl , Stefan Weigand , Achim Feurer
发明人： Cristina Alonso-Alija , Erwin Bischoff , Klaus Münter , Johannes-Peter Stasch , Elke Stahl , Stefan Weigand , Achim Feurer
IPC分类号： C07D471/04 , A61K31/506 , C07D231/38
CPC分类号： C07D471/04 , A61K31/506 , A61K45/06 , A61K2300/00
摘要： The present invention relates to compounds which stimulate soluble guanylate cyclase, to the preparation thereof and to the use thereof as medicaments, in particular as medicaments for the treatment of cardiovascular disorders and/or sexual dysfunction.
摘要翻译： 本发明涉及刺激可溶性鸟苷酸环化酶，其制备及其作为药物的用途，特别是作为用于治疗心血管疾病和/或性功能障碍的药物的化合物。
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18.发明授权Endothelin antagonist and beta receptor blocking agent as combined preparations 有权内皮素拮抗剂和β受体阻断剂作为联合制剂公开(公告)号：US06352992B1
公开(公告)日：2002-03-05
申请号：US09508989
申请日：2000-03-20
申请人： Michael Kirchengast , Klaus Münter
发明人： Michael Kirchengast , Klaus Münter
IPC分类号： A61K31505
CPC分类号： A61K45/06
摘要： A combination of endothelin antagonists and beta-receptor blockers is described. The combination is suitable for controlling diseases.
摘要翻译： 描述了内皮素拮抗剂和β-受体阻滞剂的组合。 该组合适用于控制疾病。
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公开(公告)号：US20100261759A1
公开(公告)日：2010-10-14
申请号：US12665718
申请日：2008-06-07
申请人： Swen Allerheiligen , Marcus Bauser , Hartmut Schirok , Ulrich Rester , Stefan Heitmeier , Christoph Gerdes , Georges Von Degenfeld , Elke Dittrich-Wengenroth , Uwe Saatman , Julia Strassburger , Klaus Münter , Mark Jean Gnoth , Dieter Lang
发明人： Swen Allerheiligen , Marcus Bauser , Hartmut Schirok , Ulrich Rester , Stefan Heitmeier , Christoph Gerdes , Georges Von Degenfeld , Elke Dittrich-Wengenroth , Uwe Saatman , Julia Strassburger , Klaus Münter , Mark Jean Gnoth , Dieter Lang
IPC分类号： A61K31/4439 , C07D413/14 , A61P7/02
CPC分类号： C07D413/14
摘要： The invention relates to novel substituted oxazolidinones, to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular of thromboembolic disorders.
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20.发明授权Derivatives of 2-(1-benzyl-1H-pyrazolo(3,4-B)pyridine-3-yl)-5(-4-pyridinyl)l-4-pyrimidinamines and the use thereof as quanylate cyclase stimulators 有权2-（1-苄基-1H-吡唑并（3,4-B）吡啶-3-基）-5（-4-吡啶基）-1- [4-嘧啶胺]的衍生物及其作为苯甲酸酯环化酶刺激剂的用途公开(公告)号：US07135474B2
公开(公告)日：2006-11-14
申请号：US10514909
申请日：2003-05-05
IPC分类号： C07D471/04 , A61K31/505 , C07D231/38
CPC分类号： C07D471/04
摘要： This application relates to compounds of the formula (I) in which R1 is chlorine, cyano, trifluoromethyl or methoxy and R2 is hydrogen or flurorine; or R1 and R2 are both fluorine; and to pharmaceutically acceptable salts of these materials. Pharmaceutical compositions containing these materials, and methods of using them in treatment of hypertension and sexual dysfunction are also disclosed and claimed.
摘要翻译： 本申请涉及式（I）化合物，其中R 1是氯，氰基，三氟甲基或甲氧基，R 2是氢或氟磺酰; 或R 1和R 2均为氟; 以及这些材料的药学上可接受的盐。 还公开并要求保护含有这些材料的药物组合物和使用它们治疗高血压和性功能障碍的方法。
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