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公开(公告)号：US07723347B2
公开(公告)日：2010-05-25
申请号：US11587630
申请日：2005-04-14
申请人： Hartmut Schirok , Johannes-Peter Stasch , Raimund Kast , Klaus Münter , Marc Jean Gnoth , Santiago Figureoa Perez , Michael Thutewohl , Samir Bennabi , Dieter Lang , Joachim Mittendorf , Martin Radtke , Heimo Ehmke
发明人： Hartmut Schirok , Johannes-Peter Stasch , Raimund Kast , Klaus Münter , Marc Jean Gnoth , Santiago Figureoa Perez , Michael Thutewohl , Samir Bennabi , Dieter Lang , Joachim Mittendorf , Martin Radtke , Heimo Ehmke
IPC分类号： C07D471/04 , A61K31/437
CPC分类号： C07D471/04
摘要： The invention relates to substituted phenylaminopyrimidines, to a process for their preparation and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases in humans and animals, in particular cardiovascular disorders.
摘要翻译： 本发明涉及取代的苯基氨基嘧啶，其制备方法及其用于制备用于治疗和/或预防人和动物疾病，特别是心血管疾病的药物。
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公开(公告)号：US20080269268A1
公开(公告)日：2008-10-30
申请号：US11587630
申请日：2005-04-14
申请人： Hartmut Schirok , Johannes-Peter Stasch , Raimund Kast , Klaus Munter , Mark Jean Gnoth , Santiago Figureoa Perez , Michael Thutewohl , Samir Bennabi , Dieter Lang , Joachim Mittendorf , Martin Radtke , Heimo Ehmke
发明人： Hartmut Schirok , Johannes-Peter Stasch , Raimund Kast , Klaus Munter , Mark Jean Gnoth , Santiago Figureoa Perez , Michael Thutewohl , Samir Bennabi , Dieter Lang , Joachim Mittendorf , Martin Radtke , Heimo Ehmke
IPC分类号： A61K31/506 , C07D401/14 , A61P9/00 , A61P15/00
CPC分类号： C07D471/04
摘要： The invention relates to substituted phenylaminopyrimidines, to a process for their preparation and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases in humans and animals, in particular cardiovascular disorders.
摘要翻译： 本发明涉及取代的苯基氨基嘧啶，其制备方法及其用于制备用于治疗和/或预防人和动物疾病，特别是心血管疾病的药物。
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3.发明授权公开(公告)号：US08329716B2
公开(公告)日：2012-12-11
申请号：US11547975
申请日：2005-03-30
申请人： Hartmut Schirok , Martin Radtke , Joachim Mittendorf , Raimund Kast , Johannes-Peter Stasch , Mark Jean Gnoth , Klaus Münter , Dieter Lang , Santiago Figueroa Perez , Michael Thutewohl , Samir Bennabi , Heimo Ehmke
发明人： Hartmut Schirok , Martin Radtke , Joachim Mittendorf , Raimund Kast , Johannes-Peter Stasch , Mark Jean Gnoth , Klaus Münter , Dieter Lang , Santiago Figueroa Perez , Michael Thutewohl , Samir Bennabi , Heimo Ehmke
IPC分类号： C07D471/04 , A61K31/437
CPC分类号： C07D471/04
摘要： The invention relates to hetaryloxy-substituted phenylaminopyrimidines, to a process for their preparation and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases in humans and animals, in particular cardiovascular disorders.
摘要翻译： 本发明涉及苯甲酰氧基取代的苯基氨基嘧啶，其制备方法及其用于制备用于治疗和/或预防人和动物疾病，特别是心血管疾病的药物。
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4.发明申请公开(公告)号：US20080139595A1
公开(公告)日：2008-06-12
申请号：US11547975
申请日：2005-03-30
申请人： Hartmut Schirok , Martin Radtke , Joachim Mittendorf , Raimund Kast , Johannes-Peter Stasch , Mark Jean Gnoth , Klaus Munter , Dieter Lang , Santiago Figueroa Perez , Michael Thutewohl , Samir Bennabi , Heimo Ehmke
发明人： Hartmut Schirok , Martin Radtke , Joachim Mittendorf , Raimund Kast , Johannes-Peter Stasch , Mark Jean Gnoth , Klaus Munter , Dieter Lang , Santiago Figueroa Perez , Michael Thutewohl , Samir Bennabi , Heimo Ehmke
IPC分类号： C07D487/04 , A61K31/506 , A61P9/00
CPC分类号： C07D471/04
摘要： The invention relates to hetaryloxy-substituted phenylaminopyrimidines, to a process for their preparation and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases in humans and animals, in particular cardiovascular disorders.
摘要翻译： 本发明涉及苯甲酰氧基取代的苯基氨基嘧啶，其制备方法及其用于制备用于治疗和/或预防人和动物疾病，特别是心血管疾病的药物。
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5.发明授权Heteroaryloxy-substituted phenylaminopyrimidines as rho-kinase inhibitors 失效杂环氧基取代的苯基氨基嘧啶作为rho激酶抑制剂公开(公告)号：US07737153B2
公开(公告)日：2010-06-15
申请号：US10531889
申请日：2003-10-16
申请人： Achim Feurer , Samir Bennabi , Heike Heckroth , Hartmut Schirok , Joachim Mittendorf , Raimund Kast , Johannes-Peter Stasch , Jean Mark Gnoth , Klaus Münter , Dieter Lang , Santiago Figueroa Perez , Heimo Ehmke
发明人： Achim Feurer , Samir Bennabi , Heike Heckroth , Hartmut Schirok , Joachim Mittendorf , Raimund Kast , Johannes-Peter Stasch , Jean Mark Gnoth , Klaus Münter , Dieter Lang , Santiago Figueroa Perez , Heimo Ehmke
IPC分类号： A01N43/90 , A61K31/519 , A61K31/505 , C07D487/00 , C07D239/02 , C07D401/00 , C07D403/00 , C07D405/00 , C07D409/00 , C07D411/00 , C07D413/00 , C07D417/00 , C07D419/00
CPC分类号： C07D401/14 , C07D403/12 , C07D471/04
摘要： The invention relates to heteroaryloxy-substituted phenylaminopyrimidines, to methods for the production thereof, and to the use of the same for producing medicaments for the treatment and/or prophylaxis of diseases, especially cardiovascular diseases. The inventive compounds inhibit Rho-Kinase.
摘要翻译： 本发明涉及杂芳氧基取代的苯基氨基嘧啶，其制备方法及其用于制备用于治疗和/或预防疾病，特别是心血管疾病的药物。 本发明化合物抑制Rho-激酶。
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6.发明申请Heteroaryloxy-substituted phenylaminopyrimidines as rho-kinase inhibitors 失效杂环氧基取代的苯基氨基嘧啶作为rho激酶抑制剂公开(公告)号：US20060241127A1
公开(公告)日：2006-10-26
申请号：US10531889
申请日：2003-10-16
申请人： Achim Feurer , Samir Bennabi , Heike Heckroth , Hartmut Schirok , Joachim Mittendorf , Raimund Kast , Johannes-Peter Stasch , Jean Gnoth , Klaus Munter , Dieter Lang , Santiago Perez , Heimo Ehmke
发明人： Achim Feurer , Samir Bennabi , Heike Heckroth , Hartmut Schirok , Joachim Mittendorf , Raimund Kast , Johannes-Peter Stasch , Jean Gnoth , Klaus Munter , Dieter Lang , Santiago Perez , Heimo Ehmke
IPC分类号： A61K31/519 , A61K31/513 , A61K31/506 , C07D487/04 , C07D403/02
CPC分类号： C07D401/14 , C07D403/12 , C07D471/04
摘要： The invention relates to heteroaryloxy-substituted phenylaminopyrimidines, to methods for the production thereof, and to the use of the same for producing medicaments for the treatment and/or prophylaxis of diseases, especially cardiovascular diseases. The inventive compounds inhibit Rho-Kinase.
摘要翻译： 本发明涉及杂芳氧基取代的苯基氨基嘧啶，其制备方法及其用于制备用于治疗和/或预防疾病，特别是心血管疾病的药物。 本发明化合物抑制Rho-激酶。
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7.发明申请Pyrrolopyridine-Substituted Benzol Derivatives for Treating Cardiovascular Diseases 审中-公开用于治疗心血管疾病的吡咯并吡啶取代的苯衍生物公开(公告)号：US20080249105A1
公开(公告)日：2008-10-09
申请号：US10582184
申请日：2004-11-26
申请人： Samir Bennabi , Heike Heckroth , Hartmut Schirok , Joachim Mittendorf , Raimund Kast , Johannes-Peter Stasch , Mark Jean Gnoth , Klaus Minter , Dieter Lang , Santiago Figueroa Perez , Marcus Bauser , Achim Feurer , Heimo Ehmke
发明人： Samir Bennabi , Heike Heckroth , Hartmut Schirok , Joachim Mittendorf , Raimund Kast , Johannes-Peter Stasch , Mark Jean Gnoth , Klaus Minter , Dieter Lang , Santiago Figueroa Perez , Marcus Bauser , Achim Feurer , Heimo Ehmke
IPC分类号： A61K31/496 , C07D471/02 , A61K31/437 , A61P15/10 , A61P9/00 , C07D401/14
CPC分类号： C07D471/04
摘要： The invention relates to heteroaryl-substituted benzenes, to a process for their preparation and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases in humans and animals, in particular cardiovascular disorders.
摘要翻译： 本发明涉及杂芳基取代的苯，涉及其制备方法及其用于制备用于治疗和/或预防人和动物疾病，特别是心血管疾病的药物。
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8.发明申请3-Tetrazolyl Indazoles, 3-Tetrazolyl Pyrazolopyridines, and use Thereof 审中-公开3-四唑基吲唑，3-四唑基吡唑并吡啶，及其用途公开(公告)号：US20100113507A1
公开(公告)日：2010-05-06
申请号：US12299906
申请日：2007-04-30
申请人： Chantal Fürstner , Hartmut Schirok , Nils Griebenow , Joachim Mittendorf , Johannes-Peter Stasch , Frank Wunder
发明人： Chantal Fürstner , Hartmut Schirok , Nils Griebenow , Joachim Mittendorf , Johannes-Peter Stasch , Frank Wunder
IPC分类号： A61K31/437 , A61P9/00 , A61P11/00 , A61P25/28 , A61P25/16 , A61P29/00 , C07D471/04
CPC分类号： C07D405/14 , C07D403/04 , C07D409/14 , C07D471/04
摘要： The present application relates to novel 3-tetrazolylindazole and 3-tetrazolylpyrazolo[3,4-b]-pyridine derivatives, processes for their preparation, their use alone or in combination for the treatment and/or prophylaxis of diseases, and their use for producing medicaments for the treatment and/or prophylaxis of diseases, especially for the treatment and/or prevention of cardiovascular disorders.
摘要翻译： 本申请涉及新的3-四唑基吲唑和3-四唑基吡唑并[3,4-b] - 吡啶衍生物，其制备方法，它们单独使用或组合用于治疗和/或预防疾病及其用于生产 用于治疗和/或预防疾病的药物，特别是用于治疗和/或预防心血管疾病。
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9.发明申请公开(公告)号：US20100004235A1
公开(公告)日：2010-01-07
申请号：US12298532
申请日：2007-04-17
申请人： Hartmut Schirok , Nils Griebenow , Chantal Fürstner , Joachim Mittendorf , Johannes-Peter Stasch , Frank Wunder , Karl-Heinz Schlemmer , Stefan Heitmeier , Friederike Stoll
发明人： Hartmut Schirok , Nils Griebenow , Chantal Fürstner , Joachim Mittendorf , Johannes-Peter Stasch , Frank Wunder , Karl-Heinz Schlemmer , Stefan Heitmeier , Friederike Stoll
IPC分类号： A61K31/5377 , C07D471/02 , A61K31/437 , C07D413/14 , A61P9/00
CPC分类号： C07D471/04
摘要： The present application relates to novel heterocyclyl-substituted fused pyrazole derivatives, to processes for their preparation, to their use, alone or in combination, for the treatment and/or prevention of diseases and to their use for preparing medicaments for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of cardiovascular disorders.
摘要翻译： 本申请涉及新的杂环基取代的稠合吡唑衍生物，其制备方法，其单独或组合用于治疗和/或预防疾病及其用于制备用于治疗和/或治疗的药物的用途 预防疾病，特别是用于治疗和/或预防心血管疾病。
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10.发明申请Quinoxalinones and their use especially in the treatment of cardiovascular diseases 审中-公开喹喔啉酮及其用途特别用于治疗心血管疾病公开(公告)号：US20060247244A1
公开(公告)日：2006-11-02
申请号：US10503521
申请日：2003-01-27
申请人： Jens-Kerim Ergüden , Peter Kolkhof , Julio Castro-Palomino , Alexander Kuhl , Raimund Kast , Johannes-Peter Stasch , Hanna Tinel , Klaus Münter , Klemens Lustig , Josef Pernerstorfer , Martin Bechem , Jörg Hüser
发明人： Jens-Kerim Ergüden , Peter Kolkhof , Julio Castro-Palomino , Alexander Kuhl , Raimund Kast , Johannes-Peter Stasch , Hanna Tinel , Klaus Münter , Klemens Lustig , Josef Pernerstorfer , Martin Bechem , Jörg Hüser
IPC分类号： A61K31/498 , C07D241/36
CPC分类号： C07D403/12 , C07D241/44 , C07D401/12 , C07D405/12 , C07D409/12
摘要： The invention relates to quinoxalinones and to methods for producing the same as well as the use thereof for preparing drugs for the treatment and/or prophylaxis of diseases, especially of cardiovascular diseases.
摘要翻译： 本发明涉及喹喔啉酮及其制备方法以及其用于制备用于治疗和/或预防疾病，特别是心血管疾病的药物的用途。
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