公开(公告)号：US20130040862A1

公开(公告)日：2013-02-14

申请号：US13636799

申请日：2010-04-20

申请人： Zhiyong Li ,  Min Hu ,  Fung Suong Ou ,  Wei Wu ,  R. Stanley Williams

发明人： Zhiyong Li ,  Min Hu ,  Fung Suong Ou ,  Wei Wu ,  R. Stanley Williams

IPC分类号： C40B40/14 ,  C40B50/14 ,  C40B40/18 ,  C40B40/04 ,  B82Y15/00

CPC分类号： G01N21/658

摘要： A multi-pillar structure for molecular analysis is provided. The structure comprises at least two nanopoles, each nanopole attached at one end to a substrate and freely movable along its length. The opposite ends of the at least two nanopoles are each capable of movement toward each other to trap at least one analyte molecule at their opposite ends. Each nanopole is coated with a metal coating. An array of such multi-pillar structures is also provided. A method for preparing the multi-pillar structure is further provided.

摘要翻译： 提供了一种用于分子分析的多支柱结构。 该结构包括至少两个纳米微粒，每个纳米孔一端连接到基底上，并可沿其长度自由移动。 至少两个纳米球的相对端各自能够相互移动以在其相对端捕获至少一种分析物分子。 每个纳米孔涂有金属涂层。 还提供了这种多支柱结构的阵列。 还提供了一种制备多支柱结构的方法。

公开(公告)号：US08314932B2

公开(公告)日：2012-11-20

申请号：US12771440

申请日：2010-04-30

申请人： Fung Suong Ou ,  Zhiyong Li ,  Min Hu ,  Wei Wu

发明人： Fung Suong Ou ,  Zhiyong Li ,  Min Hu ,  Wei Wu

IPC分类号： G01J3/44

CPC分类号： G02B1/12 ,  G01N21/658

摘要： A surface-enhanced Raman spectroscopy device includes a substrate, and an ultraviolet cured resist disposed on the substrate. The ultraviolet cured resist has a pattern of cone-shaped protrusions, where each cone-shaped protrusion has a tip with a radius of curvature equal to or less than 10 nm. The ultraviolet cured resist is formed of a predetermined ratio of a photoinitiator, a cross-linking agent, and a siloxane based backbone chain. A Raman signal-enhancing material is disposed on each of the cone-shaped protrusions.

摘要翻译： 表面增强拉曼光谱装置包括基板和设置在基板上的紫外线固化抗蚀剂。 紫外线固化抗蚀剂具有锥形突起的图案，其中每个锥形突起具有等于或小于10nm的曲率半径的尖端。 紫外线固化的抗蚀剂由光引发剂，交联剂和基于硅氧烷的主链以预定比例形成。 拉曼信号增强材料设置在每个锥形突起上。

公开(公告)号：US20120013902A1

公开(公告)日：2012-01-19

申请号：US12836097

申请日：2010-07-14

申请人： Min Hu ,  Alexandre M. Bratkovski ,  Huel Pei Kuo ,  Jingjing Li ,  Zhiyong Li ,  Fung Suong Ou ,  Michael Josef Stuke ,  Michael Renne Ty Tan ,  Shih-Yuan Wang ,  Wei Wu

发明人： Min Hu ,  Alexandre M. Bratkovski ,  Huel Pei Kuo ,  Jingjing Li ,  Zhiyong Li ,  Fung Suong Ou ,  Michael Josef Stuke ,  Michael Renne Ty Tan ,  Shih-Yuan Wang ,  Wei Wu

IPC分类号： G01J3/44

CPC分类号： G01J3/18 ,  G01J3/44 ,  G01N21/65 ,  G01N2021/651

摘要： An apparatus for detecting at least one species using Raman light detection includes at least one laser source for illuminating a sample containing the at least one species. The apparatus also includes a modulating element for modulating a spatial relationship between the sample and the light beams to cause relative positions of the sample and the light beams to be oscillated, in which Raman light at differing intensity levels are configured to be emitted from the at least one species based upon the different wavelengths of the light beams illuminating the sample. The apparatus also includes a Raman light detector and a post-signal processing unit configured to detect the at least one species.

摘要翻译： 用于使用拉曼光检测来检测至少一种物质的装置包括用于照亮含有至少一种物质的样品的至少一个激光源。 该装置还包括用于调制样品与光束之间的空间关系的调制元件，以使得样品和光束的相对位置发生振荡，其中以不同强度水平的拉曼光被配置为从at 基于照射样品的光束的不同波长的至少一种物质。 该装置还包括拉曼光检测器和被配置为检测至少一种物种的后信号处理单元。

公开(公告)号：US20110188033A1

公开(公告)日：2011-08-04

申请号：US12696853

申请日：2010-01-29

申请人： Min Hu ,  Alexandre M. Bratkovski ,  Jingjing Li ,  Huei Pei Kuo ,  Zhiyong Li ,  Fung Suong Ou ,  Michael Josef Stuke ,  Michael Renne Ty Tan ,  Shih-Yuan Wang ,  Wei Wu

发明人： Min Hu ,  Alexandre M. Bratkovski ,  Jingjing Li ,  Huei Pei Kuo ,  Zhiyong Li ,  Fung Suong Ou ,  Michael Josef Stuke ,  Michael Renne Ty Tan ,  Shih-Yuan Wang ,  Wei Wu

IPC分类号： G01J3/44

CPC分类号： G01J3/44

摘要： An apparatus for detecting at least one molecule using Raman light detection includes a substrate for supporting a sample containing the at least one molecule, a laser source for emitting a laser beam to cause Raman light emission from the at least one molecule, a modulating element for modulating a spatial relationship between the laser beam and the substrate at an identified frequency to cause the Raman light to be emitted from the at least one molecule at the identified frequency, at least one detector for detecting the Raman light emitted from the at least one molecule, and a post-signal processing unit configured to process the detected Raman light emission at the identified frequency to detect the at least one molecule.

摘要翻译： 用于使用拉曼光检测检测至少一个分子的装置包括用于支撑含有至少一个分子的样品的基底，用于发射激光束以产生来自至少一个分子的拉曼光发射的激光源， 以识别的频率调制激光束和衬底之间的空间关系，以使所述拉曼光以所识别的频率从所述至少一个分子发射;至少一个检测器，用于检测从所述至少一个分子发射的拉曼光 以及后信号处理单元，被配置为处理所识别的频率处的所检测的拉曼光发射以检测所述至少一个分子。

公开(公告)号：US09244015B2

公开(公告)日：2016-01-26

申请号：US13636784

申请日：2010-04-20

申请人： Zhiyong Li ,  Min Hu ,  Fung Suong Ou ,  Wei Wu

发明人： Zhiyong Li ,  Min Hu ,  Fung Suong Ou ,  Wei Wu

IPC分类号： G01J3/44 ,  B05D5/06 ,  B44C1/22 ,  C23C16/48 ,  C25D5/02 ,  G02B5/08 ,  G01N21/65

CPC分类号： G01N21/658 ,  G01N21/648

摘要： A self-arranging, luminescence-enhancement device 101 for surface-enhanced luminescence. The self-arranging, luminescence-enhancement device 101 for surface-enhanced luminescence includes a substrate 110, and a plurality 120 of flexible columnar structures. A flexible columnar structure 120-1 of the plurality 120 includes a flexible column 120-1A, and a metallic cap 120-1B coupled to the apex 120-1 C of the flexible column 120-1A. At least the flexible columnar structure 120-1 and a second flexible columnar structure 120-2 are configured to self-arrange into a close-packed configuration with at least one molecule 220-1 disposed between at least the metallic cap 120-1B and a second metallic cap 120-2B of respective flexible columnar structure 120-1 and second flexible columnar structure 120-2.

摘要翻译： 用于表面增强发光的自配置发光增强装置101。 用于表面增强发光的自配置发光增强装置101包括基板110和多个120个柔性柱状结构。 多个120的柔性柱状结构120-1包括柔性柱120-1A以及耦合到柔性柱120-1A的顶点120-1C的金属盖120-1B。 至少柔性柱状结构120-1和第二柔性柱状结构120-2构造成自配置成紧密堆积构造，其中至少一个分子220-1设置在至少金属盖120-1B和 各个柔性柱状结构120-1的第二金属盖120-2B和第二柔性柱状结构120-2。

公开(公告)号：US08665432B2

公开(公告)日：2014-03-04

申请号：US12915148

申请日：2010-10-29

申请人： Min Hu ,  Michael Josef Stuke ,  Zhiyong Li ,  Wei Wu ,  Fung Suong Ou ,  Shih-Yuan Wang ,  Lars Helge Thylen

发明人： Min Hu ,  Michael Josef Stuke ,  Zhiyong Li ,  Wei Wu ,  Fung Suong Ou ,  Shih-Yuan Wang ,  Lars Helge Thylen

IPC分类号： G01N21/65

CPC分类号： G01J3/44 ,  G01N21/658

摘要： An apparatus for performing surface enhanced Raman spectroscopy (SERS) includes a substrate and a plurality of nano-pillars, each of the plurality of nano-pillars having a first end attached to the substrate, a second end located distally from the substrate, and a body portion extending between the first end and the second end, in which the plurality of nano-pillars are arranged in an array on the substrate, and in which each of the plurality of nano-pillars is formed of a polymer material that is functionalized to expand in the presence of a fluid to cause gaps between the plurality of nano-pillars to shrink when the fluid is supplied onto the nano-pillars.

摘要翻译： 用于进行表面增强拉曼光谱（SERS）的设备包括基底和多个纳米柱，多个纳米柱中的每一个具有连接到基底的第一端，位于远离基底的第二端，以及 主体部分在所述第一端和所述第二端之间延伸，其中所述多个纳米柱以阵列布置在所述基底上，并且所述多个纳米柱中的每一个由聚合物材料形成，所述聚合物材料被官能化为 在存在流体的情况下膨胀，以便当将流体供应到纳米支柱上时，使多个纳米柱之间的间隙收缩。

公开(公告)号：US20130027698A1

公开(公告)日：2013-01-31

申请号：US13636784

申请日：2010-04-20

申请人： Zhiyong Li ,  Min Hu ,  Fung Suong Ou ,  Wei Wu

发明人： Zhiyong Li ,  Min Hu ,  Fung Suong Ou ,  Wei Wu

IPC分类号： G01J3/44 ,  C25D5/02 ,  C23C16/48 ,  B44C1/22 ,  G02B5/08 ,  B05D5/06

CPC分类号： G01N21/658 ,  G01N21/648

摘要： A self-arranging, luminescence-enhancement device 101 for surface-enhanced luminescence. The self-arranging, luminescence-enhancement device 101 for surface-enhanced luminescence includes a substrate 110, and a plurality 120 of flexible columnar structures. A flexible columnar structure 120-1 of the plurality 120 includes a flexible column 120-1A, and a metallic cap 120-1B coupled to the apex 120-1 C of the flexible column 120-1A. At least the flexible columnar structure 120-1 and a second flexible columnar structure 120-2 are configured to self-arrange into a close-packed configuration with at least one molecule 220-1 disposed between at least the metallic cap 120-1B and a second metallic cap 120-2B of respective flexible columnar structure 120-1 and second flexible columnar structure 120-2.

摘要翻译： 用于表面增强发光的自配置发光增强装置101。 用于表面增强发光的自配置发光增强装置101包括基板110和多个120个柔性柱状结构。 多个120的柔性柱状结构120-1包括柔性柱120-1A以及耦合到柔性柱120-1A的顶点120-1C的金属盖120-1B。 至少柔性柱状结构120-1和第二柔性柱状结构120-2构造成自配置成紧密堆积构造，其中至少一个分子220-1设置在至少金属盖120-1B和 各个柔性柱状结构120-1的第二金属盖120-2B和第二柔性柱状结构120-2。

公开(公告)号：US08208137B2

公开(公告)日：2012-06-26

申请号：US12696853

申请日：2010-01-29

申请人： Min Hu ,  Alexandre M. Bratkovski ,  Jingjing Li ,  Huei Pei Kuo ,  Zhiyong Li ,  Fung Suong Ou ,  Michael Josef Stuke ,  Michael Renne Ty Tan ,  Shih-Yuan Wang ,  Wei Wu

发明人： Min Hu ,  Alexandre M. Bratkovski ,  Jingjing Li ,  Huei Pei Kuo ,  Zhiyong Li ,  Fung Suong Ou ,  Michael Josef Stuke ,  Michael Renne Ty Tan ,  Shih-Yuan Wang ,  Wei Wu

IPC分类号： G01J3/44

CPC分类号： G01J3/44

摘要： An apparatus for detecting at least one molecule using Raman light detection includes a substrate for supporting a sample containing the at least one molecule, a laser source for emitting a laser beam to cause Raman light emission from the at least one molecule, a modulating element for modulating a spatial relationship between the laser beam and the substrate at an identified frequency to cause the Raman light to be emitted from the at least one molecule at the identified frequency, at least one detector for detecting the Raman light emitted from the at least one molecule, and a post-signal processing unit configured to process the detected Raman light emission at the identified frequency to detect the at least one molecule.

摘要翻译： 用于使用拉曼光检测检测至少一个分子的装置包括用于支撑含有至少一个分子的样品的基底，用于发射激光束以产生来自至少一个分子的拉曼光发射的激光源， 以识别的频率调制激光束和衬底之间的空间关系，以使所述拉曼光以所识别的频率从所述至少一个分子发射;至少一个检测器，用于检测从所述至少一个分子发射的拉曼光 以及后信号处理单元，被配置为处理所识别的频率处的所检测的拉曼光发射以检测所述至少一个分子。

公开(公告)号：US20120105841A1

公开(公告)日：2012-05-03

申请号：US12915148

申请日：2010-10-29

申请人： Min Hu ,  Michael Josef Stuke ,  Zhiyong Li ,  Wei Wu ,  Fung Suong Ou ,  Shih-Yuan Wang ,  Lars Helge Thylen

发明人： Min Hu ,  Michael Josef Stuke ,  Zhiyong Li ,  Wei Wu ,  Fung Suong Ou ,  Shih-Yuan Wang ,  Lars Helge Thylen

IPC分类号： G01J3/44

CPC分类号： G01J3/44 ,  G01N21/658

摘要： An apparatus for performing surface enhanced Raman spectroscopy (SERS) includes a substrate and a plurality of nano-pillars, each of the plurality of nano-pillars having a first end attached to the substrate, a second end located distally from the substrate, and a body portion extending between the first end and the second end, in which the plurality of nano-pillars are arranged in an array on the substrate, and in which each of the plurality of nano-pillars is formed of a polymer material that is functionalized to expand in the presence of a fluid to cause gaps between the plurality of nano-pillars to shrink when the fluid is supplied onto the nano-pillars.

摘要翻译： 用于进行表面增强拉曼光谱（SERS）的设备包括基底和多个纳米柱，多个纳米柱中的每一个具有连接到基底的第一端，位于远离基底的第二端，以及 主体部分在所述第一端和所述第二端之间延伸，其中所述多个纳米柱以阵列布置在所述基底上，并且所述多个纳米柱中的每一个由聚合物材料形成，所述聚合物材料被官能化为 在存在流体的情况下膨胀，以便当将流体供应到纳米支柱上时，使多个纳米柱之间的间隙收缩。

公开(公告)号：US20120092660A1

公开(公告)日：2012-04-19

申请号：US12905891

申请日：2010-10-15

申请人： Wei Wu ,  Zhiyong Li ,  Shih-Yuan Wang ,  Michael Josef Stuke ,  Lars Helge Thylen ,  Fung Suong Ou ,  Min Hu

发明人： Wei Wu ,  Zhiyong Li ,  Shih-Yuan Wang ,  Michael Josef Stuke ,  Lars Helge Thylen ,  Fung Suong Ou ,  Min Hu

IPC分类号： G01J3/44

CPC分类号： G01N21/658

摘要： An apparatus for performing SERS includes a substrate and flexible nano-fingers, each of the nano-fingers having a first end attached to the substrate, a free second end, and a body portion extending between the first end and the second end, in which the nano-fingers are arranged in an array on the substrate. The apparatus also includes an active material layer disposed on each of the second ends of the plurality of nano-fingers, in which the nano-fingers are to be in a substantially collapsed state in which the active layers on at least two of the nano-fingers contact each other under dominant attractive forces between the plurality of nano-fingers and in which the active material layers are to repel each other when the active material layers are electrostatically charged.

摘要翻译： 用于执行SERS的装置包括基底和柔性纳米指，每个纳米指具有连接到基底的第一端，自由的第二端和在第一端和第二端之间延伸的主体部分，其中 纳米手指以阵列排列在基板上。 该装置还包括设置在多个纳米手指的每个第二端上的活性材料层，其中纳米指状物将处于基本上塌陷的状态，其中在至少两个纳米手指上的活性层， 手指在多个纳米手指之间的主导吸引力下彼此接触，并且当活性材料层被静电充电时，活性材料层将彼此排斥。