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公开(公告)号：US08765643B2
公开(公告)日：2014-07-01
申请号：US11680646
申请日：2007-03-01
申请人： Zhida Pan , Su Lu , Liangliang Qiang , John Yupeng Gui , John Richard Nelson , Bahram Moasser , Anup Sood , Gregory Andrew Grossmann , Wei Cai , Zhixin Zheng
发明人： Zhida Pan , Su Lu , Liangliang Qiang , John Yupeng Gui , John Richard Nelson , Bahram Moasser , Anup Sood , Gregory Andrew Grossmann , Wei Cai , Zhixin Zheng
IPC分类号： C40B40/04 , G01N33/53 , G01N33/566
摘要： The composition includes a first probe and a first initiator bonded to the first probe. The composition further includes a second probe and a second initiator bonded to the second probe. The first probe and the second probe are capable of binding to a single analyte. An associated kit, device, and method are provided.
摘要翻译： 组合物包括第一探针和结合到第一探针的第一引发剂。 组合物还包括第二探针和结合到第二探针的第二引发剂。 第一个探针和第二个探针能够结合单个分析物。 提供相关的套件，设备和方法。
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公开(公告)号：US08741813B2
公开(公告)日：2014-06-03
申请号：US11680597
申请日：2007-02-28
申请人： Su Lu , John Yupeng Gui , Bahram Moasser , Wei Cai , Zhixin Zheng , John Richard Nelson
发明人： Su Lu , John Yupeng Gui , Bahram Moasser , Wei Cai , Zhixin Zheng , John Richard Nelson
IPC分类号： C40B40/04 , G01N33/53 , G01N33/566
CPC分类号： C12Q1/6834 , G01N33/533 , G01N33/582
摘要： A composition includes a first probe capable of binding to a first analyte and a first initiator bonded to the first probe. The composition further includes a second probe capable of binding to a second analyte and a second initiator bonded to the second probe. At least one of the first initiator or the second initiator is capable of initiating a controlled polymerization reaction. An associated kit, device, and method are provided.
摘要翻译： 组合物包括能够结合第一分析物的第一探针和与第一探针结合的第一引发剂。 组合物还包括能够结合第二分析物的第二探针和与第二探针结合的第二引发剂。 第一引发剂或第二引发剂中的至少一种能够引发受控的聚合反应。 提供相关的套件，设备和方法。
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公开(公告)号：US20120122734A1
公开(公告)日：2012-05-17
申请号：US11680647
申请日：2007-03-01
申请人： Su Lu , John Yupeng Gui , Bahram Moasser , Wei Cai , Zhixin Zheng , John Richard Nelson
发明人： Su Lu , John Yupeng Gui , Bahram Moasser , Wei Cai , Zhixin Zheng , John Richard Nelson
CPC分类号： G01N33/532 , C08G61/08 , C08G2261/1452 , C08G2261/3324 , C08G2261/418 , C08G2261/94 , C40B40/04 , G01N21/6428 , G01N33/5306 , G01N2021/6439
摘要： A composition includes a first probe and a first initiator bonded to the first probe. The first probe is capable of binding to an analyte and the first initiator is capable of initiating a controlled polymerization reaction. An associated kit, device, and method are provided.
摘要翻译： 组合物包括第一探针和结合到第一探针的第一引发剂。 第一探针能够结合分析物，并且第一引发剂能够引发受控的聚合反应。 提供相关的套件，设备和方法。
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公开(公告)号：US07205385B2
公开(公告)日：2007-04-17
申请号：US10987662
申请日：2004-11-12
CPC分类号： C07D263/44 , A61K49/085 , A61K49/146
摘要： A method for synthesizing extended poly(amino acids) conjugated to imaging agents, such as DTPA, is disclosed. The amino acid is initially conjugated to the imaging agent at the monomer stage, followed by formation of the corresponding N-carboxyanhydride. The method utilizes catalyzed ring opening polymerization of the N-carboxyanhydride of the amino acid-imaging agent monomer allowing the formation of a poly(amino acid) backbone having 100% imaging agent conjugation if desired. However, the present method also permits the degree of conjugation to be controlled by copolymerizing the N-carboxyanhydride of the amino acid-imaging agent monomer with one or more unconjugated monomers, i.e. N-carboxyanhydrides of the same or of other amino acids. Various imaging agents may be employed, and new hybrid random, block, and mixed copolymers may be prepared.
摘要翻译： 公开了用于合成与显影剂缀合的延伸的聚（氨基酸）的方法，例如DTPA。 氨基酸最初在单体阶段与成像剂缀合，然后形成相应的N-羧酸酐。 该方法利用氨基酸显影剂单体的N-羧酸酐的催化开环聚合，如果需要，允许形成具有100％成像剂共轭的聚（氨基酸）主链。 然而，本方法还允许通过使氨基酸显影剂单体的N-羧酸酐与一种或多种非共轭单体，即相同或其它氨基酸的N-羧酸酐共聚来控制缀合度。 可以使用各种成像剂，并且可以制备新的杂化随机，嵌段和混合共聚物。
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