SURFACE EXPRESSION VECTOR FOR FUSION PROTEIN OF MYO-2 PEPTIDE MULTIMER AND MYOSTATIN, AND MICROORGANISM TRANSFORMED BY THEREOF
    11.
    发明申请
    SURFACE EXPRESSION VECTOR FOR FUSION PROTEIN OF MYO-2 PEPTIDE MULTIMER AND MYOSTATIN, AND MICROORGANISM TRANSFORMED BY THEREOF 有权
    MYO-2肽多糖和肌糖蛋白融合蛋白的表面表达载体及其转化的微生物

    公开(公告)号:US20100226891A1

    公开(公告)日:2010-09-09

    申请号:US12682453

    申请日:2007-11-30

    CPC分类号: C07K14/475

    摘要: The present invention relates to a fusion protein in which a myostatin mature protein is fused to a multimer of myostatin-derived antigenic peptide Myo-2, a surface expression vector containing a polynucleotide encoding the fusion protein, a recombinant microorganism transformed with the vector, and a feedstuff additive or a pharmaceutical composition containing the microorganism as an effective ingredient. The feedstuff additive or pharmaceutical composition according to the present invention can be used for muscle development and regulation of muscle growth in livestock and poultry, as well as for preventing and treating muscle-wasting diseases and degenerative diseases such as muscular dystrophy, muscular atrophy and the like. In addition, the transformed strain shows the same effect even if the strain itself after culture thereof is directly used, and thus it is very economical.

    摘要翻译: 本发明涉及一种融合蛋白,其中肌生成抑制素成熟蛋白质与产生肌生成抑制素的抗原肽Myo-2的多聚体融合,含有编码融合蛋白的多核苷酸的表面表达载体,用载体转化的重组微生物,以及 饲料添加剂或含有该微生物作为有效成分的药物组合物。 根据本发明的饲料添加剂或药物组合物可用于肌肉发育和调节家畜和家禽中的肌肉生长,以及用于预防和治疗肌肉消瘦疾病和退行性疾病如肌营养不良症,肌肉萎缩症和 喜欢。 此外,即使直接使用其培养后的菌株本身,转化菌株也显示相同的效果,因此是非常经济的。

    HIV-like particles and the use thereof
    12.
    发明授权
    HIV-like particles and the use thereof 有权
    HIV样颗粒及其用途

    公开(公告)号:US07517683B2

    公开(公告)日:2009-04-14

    申请号:US10466134

    申请日:2002-01-08

    摘要: Disclosed are alphavirus-based expression vectors expressing env, gag, pro, and/or pol genes of HIV-1, their transcripts, and transformed host cells. The present invention describes the expression of the Gag, Env, Pol, and/or Pro Proteins using the above expression vectors, and HIV-like particles (HIVLPs) composed of the above recombinant proteins. The virus-like particles (VLPs) of the present invention, as the mature and infective particles, are very useful as an antigen for a diagnostic kit for HIV infection as well as for a vaccine composition for prevention of HIV infection.

    摘要翻译: 公开了表达HIV-1,其转录物和转化的宿主细胞的env,gag,pro和/或pol基因的基于甲病毒的表达载体。 本发明描述了使用上述表达载体的Gag,Env,Pol和/或Pro蛋白以及由上述重组蛋白组成的HIV样颗粒(HIVLP)的表达。 作为成熟和感染性颗粒的本发明的病毒样颗粒(VLP)作为用于HIV感染的诊断试剂盒的抗原以及用于预防HIV感染的疫苗组合物是非常有用的。