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Patent Agency Ranking
公开(公告)号：US20190382500A1
公开(公告)日：2019-12-19
申请号：US16439495
申请日：2019-06-12
Applicant: Novartis AG
Inventor： Aida Abujoub , John Blankenship , Dexiu Bu , Tony Fleming , Brian Holmberg , Connie Hong , Lu Huang , Chonghui Zhang
IPC: C07K16/28 , C07K14/725 , C07K14/705 , C12N5/0783 , A61P35/00 , A61K35/17
Abstract: The invention provides compositions and methods for treating diseases associated with expression of BCMA. The invention also relates to chimeric antigen receptor (CAR) specific to BCMA, vectors encoding the same, and recombinant T cells comprising the BCMA CAR. The invention also includes methods of administering a genetically modified T cell expressing a CAR that comprises a BCMA binding domain.
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公开(公告)号：US11939389B2
公开(公告)日：2024-03-26
申请号：US18170969
申请日：2023-02-17
Applicant: Novartis AG
Inventor： Aida Abujoub , John Blankenship , Dexiu Bu , Tony Fleming , Brian Holmberg , Connie Hong , Lu Huang , Chonghui Zhang
IPC: C07K16/28 , A61K35/17 , A61P35/00 , C07K14/705 , C07K14/725 , C12N5/0783 , A61K38/00
CPC classification number: C07K16/2878 , A61K35/17 , A61P35/00 , C07K14/7051 , C07K14/70578 , C12N5/0636 , A61K38/00 , C07K2317/565 , C07K2317/622 , C07K2317/732 , C07K2317/76 , C07K2319/02 , C07K2319/03 , C07K2319/30 , C07K2319/33
Abstract: The invention provides compositions and methods for treating diseases associated with expression of BCMA. The invention also relates to chimeric antigen receptor (CAR) specific to BCMA, vectors encoding the same, and recombinant T cells comprising the BCMA CAR. The invention also includes methods of administering a genetically modified T cell expressing a CAR that comprises a BCMA binding domain.
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公开(公告)号：US20230183368A1
公开(公告)日：2023-06-15
申请号：US18170969
申请日：2023-02-17
Applicant: Novartis AG
Inventor： Aida Abujoub , John Blankenship , Dexiu Bu , Tony Fleming , Brian Holmberg , Connie Hong , Lu Huang , Chonghui Zhang
IPC: C07K16/28 , A61P35/00 , A61K35/17 , C07K14/725 , C07K14/705 , C12N5/0783
CPC classification number: C07K16/2878 , A61P35/00 , A61K35/17 , C07K14/7051 , C07K14/70578 , C12N5/0636 , A61K38/00
Abstract: The invention provides compositions and methods for treating diseases associated with expression of BCMA. The invention also relates to chimeric antigen receptor (CAR) specific to BCMA, vectors encoding the same, and recombinant T cells comprising the BCMA CAR. The invention also includes methods of administering a genetically modified T cell expressing a CAR that comprises a BCMA binding domain.
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公开(公告)号：US11608382B2
公开(公告)日：2023-03-21
申请号：US16439495
申请日：2019-06-12
Applicant: Novartis AG
Inventor： Aida Abujoub , John Blankenship , Dexiu Bu , Tony Fleming , Brian Holmberg , Connie Hong , Lu Huang , Chonghui Zhang
IPC: C07K16/28 , A61P35/00 , A61K35/17 , C07K14/725 , C07K14/705 , C12N5/0783 , A61K38/00
Abstract: The invention provides compositions and methods for treating diseases associated with expression of BCMA. The invention also relates to chimeric antigen receptor (CAR) specific to BCMA, vectors encoding the same, and recombinant T cells comprising the BCMA CAR. The invention also includes methods of administering a genetically modified T cell expressing a CAR that comprises a BCMA binding domain.
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公开(公告)号：US20210139585A1
公开(公告)日：2021-05-13
申请号：US16877878
申请日：2020-05-19
Applicant: Novartis AG
Inventor： Brian Granda , Amy Rayo , Connie Hong , Dattananda Chelur , Haihui Lu , Regis Cebe , Sunyoung Jang
Abstract: The present disclosure provides CD19 binding molecules that specifically bind to CD19, including monospecific, bispecific and trispecific binding molecules, conjugates comprising the CD19 binding molecules, and pharmaceutical compositions comprising the CD19 binding molecules and the conjugates. The disclosure further provides methods of using the C19 binding molecules to treat diseases and disorders associated with expression of CD19. The disclosure yet further provides recombinant host cells engineered to express the CD19 binding molecules and methods of producing the CD19 binding molecules by culturing the host cells under conditions in which the CD19 binding molecules are expressed.
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