公开(公告)号：US20160193308A1

公开(公告)日：2016-07-07

申请号：US14916448

申请日：2014-08-27

Applicant: OSAKA UNIVERSITY

Inventor： Hironori NAKAGAMI ,  Ryuichi MORISHITA ,  Hiroshi KORIYAMA

IPC: A61K39/00

CPC classification number: A61K39/0005 ,  A61K2039/55594 ,  A61K2039/58 ,  C07K16/2896 ,  C07K16/40 ,  C07K2317/76 ,  C07K2317/94 ,  C12N9/6421

Abstract: The present invention provides a vaccine for the prophylaxis or treatment of diabetes using a polypeptide containing the amino acid sequence shown by SEQ ID NO: 2 or an amino acid sequence of a non-human mammal, which corresponds to SEQ ID NO: 2, and the like as an immunogen, which induces a neutralizing antibody to DPP-4, and a prophylactic or therapeutic agent for diabetes, which contains a DDP-4 neutralizing antibody that recognizes a partial amino acid sequence of the aforementioned DDP-4.

Abstract translation: 本发明提供了使用含有SEQ ID NO：2所示的氨基酸序列的多肽或非人哺乳动物的氨基酸序列（其对应于SEQ ID NO：2）预防或治疗糖尿病的疫苗，以及 作为免疫原的类似物，其诱导DPP-4的中和抗体，以及含有识别上述DDP-4的部分氨基酸序列的DDP-4中和抗体的糖尿病预防或治疗剂。