公开(公告)号：US20160193308A1

公开(公告)日：2016-07-07

申请号：US14916448

申请日：2014-08-27

Applicant: OSAKA UNIVERSITY

Inventor： Hironori NAKAGAMI ,  Ryuichi MORISHITA ,  Hiroshi KORIYAMA

IPC: A61K39/00

CPC classification number: A61K39/0005 ,  A61K2039/55594 ,  A61K2039/58 ,  C07K16/2896 ,  C07K16/40 ,  C07K2317/76 ,  C07K2317/94 ,  C12N9/6421

Abstract: The present invention provides a vaccine for the prophylaxis or treatment of diabetes using a polypeptide containing the amino acid sequence shown by SEQ ID NO: 2 or an amino acid sequence of a non-human mammal, which corresponds to SEQ ID NO: 2, and the like as an immunogen, which induces a neutralizing antibody to DPP-4, and a prophylactic or therapeutic agent for diabetes, which contains a DDP-4 neutralizing antibody that recognizes a partial amino acid sequence of the aforementioned DDP-4.

Abstract translation: 本发明提供了使用含有SEQ ID NO：2所示的氨基酸序列的多肽或非人哺乳动物的氨基酸序列（其对应于SEQ ID NO：2）预防或治疗糖尿病的疫苗，以及 作为免疫原的类似物，其诱导DPP-4的中和抗体，以及含有识别上述DDP-4的部分氨基酸序列的DDP-4中和抗体的糖尿病预防或治疗剂。

公开(公告)号：US20170275336A1

公开(公告)日：2017-09-28

申请号：US15514310

申请日：2015-09-25

Applicant: OSAKA UNIVERSITY

Inventor： Hironori NAKAGAMI ,  Ryuichi MORISHITA ,  Hiroshi KORIYAMA ,  Akiko TENMA

IPC: C07K7/08 ,  A61K8/64 ,  A61Q7/00 ,  A61K39/39

CPC classification number: C07K7/08 ,  A61K8/64 ,  A61K38/00 ,  A61K39/39 ,  A61K2039/55516 ,  A61Q7/00

Abstract: An object of the present invention is to provide a novel peptide and a novel immunostimulant or hair grower containing the peptide as an active ingredient. The present invention provides a peptide of 23 or less amino acids comprising the amino acid sequence LHRLKRLRKRL (SEQ ID NO: 1), preferably the amino acid sequence LHRLKRLRKRLK (SEQ ID NO: 9), and also provides an immunostimulant containing the peptide, a vaccine adjuvant containing the peptide, a vaccine composition containing the peptide, and a hair grower containing the peptide.

公开(公告)号：US20170258895A1

公开(公告)日：2017-09-14

申请号：US15528502

申请日：2015-11-20

Applicant: ANGES MG, INC. ,  OSAKA UNIVERSITY ,  DS PHARMA ANIMAL HEALTH CO., LTD.

Inventor： Hironori NAKAGAMI ,  Ryuichi MORISHITA ,  Hiroshi KORIYAMA ,  Hideki TOMIOKA ,  Kenji NAOHARA

IPC: A61K39/29 ,  A61K39/00 ,  C12N7/00

Abstract: The present invention provides a combination preparation for inducing a specific immune response to an antigenic peptide, which contains (I) the antigenic peptide, and (II) an expression vector encoding a chimeric hepatitis B virus core antigen polypeptide, into which the antigenic peptide has been inserted or added, wherein said antigenic peptide is inserted in a region of amino acid residues 74-87 or 130-138 of the hepatitis B virus core antigen polypeptide, or added to the N-terminal or C-terminal of the hepatitis B virus core antigen polypeptide, wherein the antigenic peptide of (I) and the expression vector of (II) are substantially simultaneously administered to a subject.

公开(公告)号：US20160319013A1

公开(公告)日：2016-11-03

申请号：US15108415

申请日：2014-12-26

Applicant: OSAKA UNIVERSITY

Inventor： Hiroshi KORIYAMA ,  Hironori NAKAGAMI ,  Ryuichi MORISHITA

IPC: C07K16/24 ,  A61K39/00

CPC classification number: C07K16/244 ,  A61K39/0005 ,  C07K2317/34 ,  C07K2317/76

Abstract: The present invention provides a vaccine against IL-17A, which uses, as an immunogen, a polypeptide containing the amino acid sequence shown in SEQ ID NO: 1, or an amino acid sequence derived from a non-human mammal, which corresponds to SEQ ID NO: 1, a prophylactic or therapeutic agent containing the vaccine for diseases involving IL-17A as an aggravation factor, and the like.

Abstract translation: 本发明提供一种针对IL-17A的疫苗，其使用包含SEQ ID NO：1所示的氨基酸序列的多肽或来自非人哺乳动物的氨基酸序列作为免疫原，其对应于SEQ ID NO： ID NO：1，含有涉及IL-17A的疾病疫苗作为加重因子的预防或治疗剂等。