公开(公告)号：US20200023045A1

公开(公告)日：2020-01-23

申请号：US16486768

申请日：2018-02-20

申请人： OSAKA UNIVERSITY ,  FUNPEP CO., LTD.

发明人： Munehisa SHIMAMURA ,  Tomohiro KAWANO ,  Hironori NAKAGAMI ,  Ryuichi MORISHITA ,  Hideki MOCHIZUKI ,  Akiko TENMA ,  Takako EHARA

IPC分类号： A61K39/00 ,  A61K47/42 ,  A61P9/10 ,  A61P7/02 ,  C07K14/435 ,  A61K39/39

摘要： Provided is an immunogenic composition comprising an antigenic peptide capable of inducing production of a neutralizing antibody against S100A9 and a carrier protein. The immunogenic composition can be used as a highly safe antithrombotic vaccine having antithrombotic effect without a long-term bleeding risk and is useful for the prevention of a disease associated with thrombus formation in which platelet aggregation is involved, particularly for the prevention of recurrent ischemic stroke.

公开(公告)号：US20170275336A1

公开(公告)日：2017-09-28

申请号：US15514310

申请日：2015-09-25

申请人： OSAKA UNIVERSITY

发明人： Hironori NAKAGAMI ,  Ryuichi MORISHITA ,  Hiroshi KORIYAMA ,  Akiko TENMA

IPC分类号： C07K7/08 ,  A61K8/64 ,  A61Q7/00 ,  A61K39/39

CPC分类号： C07K7/08 ,  A61K8/64 ,  A61K38/00 ,  A61K39/39 ,  A61K2039/55516 ,  A61Q7/00

摘要： An object of the present invention is to provide a novel peptide and a novel immunostimulant or hair grower containing the peptide as an active ingredient. The present invention provides a peptide of 23 or less amino acids comprising the amino acid sequence LHRLKRLRKRL (SEQ ID NO: 1), preferably the amino acid sequence LHRLKRLRKRLK (SEQ ID NO: 9), and also provides an immunostimulant containing the peptide, a vaccine adjuvant containing the peptide, a vaccine composition containing the peptide, and a hair grower containing the peptide.

公开(公告)号：US20230330214A1

公开(公告)日：2023-10-19

申请号：US18028613

申请日：2021-09-30

申请人： OSAKA UNIVERSITY ,  TAKARA BIO INC. ,  ANGES, INC.

发明人： Hironori NAKAGAMI ,  Ryuichi MORISHITA ,  Hiroki HAYASHI ,  Yasunori AMAISHI ,  Sachiko OKAMOTO ,  Junichi MINENO ,  Hisato IKAI ,  Junko MICHIBATA ,  Takao KOMATSUNO

IPC分类号： A61K39/215 ,  A61P37/04

CPC分类号： A61K39/215 ,  A61P37/04 ,  A61K2039/53

摘要： Provided is DNA that: encodes a coronavirus (SARS CoV-2) spike protein or a fragment thereof; and has been optimized to partially or fully exhibit a codon included in a DNA sequence.

公开(公告)号：US20190105388A1

公开(公告)日：2019-04-11

申请号：US16087799

申请日：2017-03-24

申请人： OSAKA UNIVERSITY ,  FUNPEP CO., LTD.

发明人： Hironori NAKAGAMI ,  Ryuichi MORISHITA ,  Akiko TENMA

IPC分类号： A61K39/39 ,  A61P37/04 ,  A61K39/395 ,  A61K39/00

摘要： The present invention provides a vaccine containing a complex of a peptide consisting of the amino acid sequence of SEQ ID NO: 1 and an epitope of a disease-causing biological protein such as DPP4, IL-17A, IgE, S100A9 or PCSK9, which vaccine uses a less antigenic carrier protein and is capable of inducing antibody production to serve as an effective vaccine.

公开(公告)号：US20170258895A1

公开(公告)日：2017-09-14

申请号：US15528502

申请日：2015-11-20

申请人： ANGES MG, INC. ,  OSAKA UNIVERSITY ,  DS PHARMA ANIMAL HEALTH CO., LTD.

发明人： Hironori NAKAGAMI ,  Ryuichi MORISHITA ,  Hiroshi KORIYAMA ,  Hideki TOMIOKA ,  Kenji NAOHARA

IPC分类号： A61K39/29 ,  A61K39/00 ,  C12N7/00

摘要： The present invention provides a combination preparation for inducing a specific immune response to an antigenic peptide, which contains (I) the antigenic peptide, and (II) an expression vector encoding a chimeric hepatitis B virus core antigen polypeptide, into which the antigenic peptide has been inserted or added, wherein said antigenic peptide is inserted in a region of amino acid residues 74-87 or 130-138 of the hepatitis B virus core antigen polypeptide, or added to the N-terminal or C-terminal of the hepatitis B virus core antigen polypeptide, wherein the antigenic peptide of (I) and the expression vector of (II) are substantially simultaneously administered to a subject.

公开(公告)号：US20160319013A1

公开(公告)日：2016-11-03

申请号：US15108415

申请日：2014-12-26

申请人： OSAKA UNIVERSITY

发明人： Hiroshi KORIYAMA ,  Hironori NAKAGAMI ,  Ryuichi MORISHITA

IPC分类号： C07K16/24 ,  A61K39/00

CPC分类号： C07K16/244 ,  A61K39/0005 ,  C07K2317/34 ,  C07K2317/76

摘要： The present invention provides a vaccine against IL-17A, which uses, as an immunogen, a polypeptide containing the amino acid sequence shown in SEQ ID NO: 1, or an amino acid sequence derived from a non-human mammal, which corresponds to SEQ ID NO: 1, a prophylactic or therapeutic agent containing the vaccine for diseases involving IL-17A as an aggravation factor, and the like.

摘要翻译： 本发明提供一种针对IL-17A的疫苗，其使用包含SEQ ID NO：1所示的氨基酸序列的多肽或来自非人哺乳动物的氨基酸序列作为免疫原，其对应于SEQ ID NO： ID NO：1，含有涉及IL-17A的疾病疫苗作为加重因子的预防或治疗剂等。

公开(公告)号：US20230374103A1

公开(公告)日：2023-11-23

申请号：US18027695

申请日：2021-09-27

申请人： OSAKA UNIVERSITY

发明人： Munehisa SHIMAMURA ,  Hironori NAKAGAMI ,  Ryuichi MORISHITA

IPC分类号： C07K14/705 ,  A61P11/00 ,  A61P35/00

CPC分类号： C07K14/70575 ,  A61P11/00 ,  A61P35/00 ,  A61K38/00

摘要： Provided are preventive or therapeutic agents for fibrotic diseases and cancer. A Wnt signaling pathway inhibitor or a preventive and therapeutic agent for fibrotic diseases or cancer, both comprising an oligopeptide consisting of an amino acid sequence containing a DE loop sequence of RANKL protein and a β-strand sequence of RANKL protein placed adjacent to the N-terminal side of the DE loop sequence.

公开(公告)号：US20230310561A1

公开(公告)日：2023-10-05

申请号：US18023573

申请日：2021-09-07

申请人： OSAKA UNIVERSITY

发明人： Hironori NAKAGAMI ,  Ryuichi MORISHITA ,  Shuko TAKEDA ,  Hiroki HAYASHI

IPC分类号： A61K39/00 ,  A61P25/28

CPC分类号： A61K39/0005 ,  A61P25/28 ,  A61K2039/6031 ,  A61K2039/575

摘要： The present invention provides an immunogenic composition comprising an antigenic peptide and a carrier protein, wherein the antigenic peptide is capable of eliciting production of an antibody against a phosphorylated tau protein and is a human tau protein fragment containing (1) YSpSPGpSPG (SEQ ID NO: 2), (2) AKpSpTPpTAE (SEQ ID NO: 5), (3) AKpSpTPTAE (SEQ ID NO: 31), (4) AKpSTPpTAE (SEQ ID NO: 32), (5) AKSpTPpTAE (SEQ ID NO: 33), or (6) IVpYKpSPV (SEQ ID NO: 24).

公开(公告)号：US20210205446A1

公开(公告)日：2021-07-08

申请号：US17200552

申请日：2021-03-12

申请人： OSAKA UNIVERSITY ,  FUNPEP CO., LTD.

发明人： Hironori NAKAGAMI ,  Ryuichi MORISHITA ,  Akiko TENMA

IPC分类号： A61K39/39 ,  A61K39/00 ,  A61P37/04 ,  A61K39/395

摘要： The present invention provides a vaccine containing a complex of a peptide consisting of the amino acid sequence of SEQ ID NO: 1 and an epitope of a disease-causing biological protein such as DPP4, IL-17A, IgE, S100A9 or PCSK9, which vaccine uses a less antigenic carrier protein and is capable of inducing antibody production to serve as an effective vaccine.

公开(公告)号：US20160193308A1

公开(公告)日：2016-07-07

申请号：US14916448

申请日：2014-08-27

申请人： OSAKA UNIVERSITY

发明人： Hironori NAKAGAMI ,  Ryuichi MORISHITA ,  Hiroshi KORIYAMA

IPC分类号： A61K39/00

CPC分类号： A61K39/0005 ,  A61K2039/55594 ,  A61K2039/58 ,  C07K16/2896 ,  C07K16/40 ,  C07K2317/76 ,  C07K2317/94 ,  C12N9/6421

摘要： The present invention provides a vaccine for the prophylaxis or treatment of diabetes using a polypeptide containing the amino acid sequence shown by SEQ ID NO: 2 or an amino acid sequence of a non-human mammal, which corresponds to SEQ ID NO: 2, and the like as an immunogen, which induces a neutralizing antibody to DPP-4, and a prophylactic or therapeutic agent for diabetes, which contains a DDP-4 neutralizing antibody that recognizes a partial amino acid sequence of the aforementioned DDP-4.

摘要翻译： 本发明提供了使用含有SEQ ID NO：2所示的氨基酸序列的多肽或非人哺乳动物的氨基酸序列（其对应于SEQ ID NO：2）预防或治疗糖尿病的疫苗，以及 作为免疫原的类似物，其诱导DPP-4的中和抗体，以及含有识别上述DDP-4的部分氨基酸序列的DDP-4中和抗体的糖尿病预防或治疗剂。