公开(公告)号：US20240368235A1

公开(公告)日：2024-11-07

申请号：US18776908

申请日：2024-07-18

Applicant: StemRIM Inc. ,  OSAKA UNIVERSITY

Inventor： Katsuto TAMAI ,  Takashi SHIMBO ,  Takehiko YAMAZAKI

IPC: C07K14/47 ,  A61K38/00 ,  A61P1/00 ,  A61P17/06 ,  A61P37/06

Abstract: The present inventors identified many nuclear proteins contained in the extract of skin tissue by mass spectrometry, randomly selected multiple partial amino acid sequences of the nuclear proteins, chemically synthesized peptides consisting of the partial amino acid sequences, and examined their activity of mobilizing mesenchymal stem cells. As a result, it was found that these multiple peptides show the activity of mobilizing mesenchymal stem cells into peripheral blood, even though their amino acid sequences are completely different from each other. The inventors also found that fragment peptides of the nuclear proteins have therapeutic effects on diseases characterized by inflammation and abnormalities of the immune system (e.g., inflammatory bowel disease and psoriasis). Based on these findings, a new regenerative medicine technology that can overcome the problems of cell transplantation therapy is provided.

公开(公告)号：US20240299496A1

公开(公告)日：2024-09-12

申请号：US18697330

申请日：2022-09-30

Applicant: Osaka University ,  Niigata University ,  StemRIM Inc.

Inventor： Katsuto TAMAI ,  Takashi SHIMBO ,  Shuji TERAI ,  Atsunori TSUCHIYA ,  Takehiko YAMAZAKI

IPC: A61K38/19 ,  A61P1/16

CPC classification number: A61K38/19 ,  A61P1/16

Abstract: The present inventors have discovered that a peptide derived from HMGB1 can be used as a therapeutic and/or preventive agent for fatty liver, nonalcoholic steatohepatitis, and various symptoms accompanied by the fatty liver. On the basis of this discovery, the present application provides a use of the peptide derived from HMGB1 which is different from conventional uses.

公开(公告)号：US20220380420A1

公开(公告)日：2022-12-01

申请号：US17817084

申请日：2022-08-03

Applicant: StemRIM Inc. ,  OSAKA UNIVERSITY

Inventor： Katsuto TAMAI ,  Takashi SHIMBO ,  Takehiko YAMAZAKI

IPC: C07K14/47 ,  A61P17/06

Abstract: The present inventors discovered that an HMGB1 fragment peptide having a specific amino acid sequence exhibits an effect of suppressing erythema, scaling (desquamation), and thickening (infiltration) of the skin in an animal model of psoriasis. Based on these findings, pharmaceutical compositions for the prevention and/or treatment of psoriasis, which comprise the HMGB1 fragment peptide having the specific amino acid sequence are provided.

公开(公告)号：US20220265787A1

公开(公告)日：2022-08-25

申请号：US17631072

申请日：2020-07-30

Applicant: STEMRIM INC. ,  OSAKA UNIVERSITY

Inventor： Katsuto TAMAI ,  Takashi SHIMBO ,  Takehiko YAMAZAKI

IPC: A61K38/57 ,  A61K9/00 ,  A61P1/04 ,  A61P43/00 ,  C12N5/0775

Abstract: The present disclosure includes a composition for promoting growth or suppressing decrease of mesenchymal stem cells comprising serpin A3.

公开(公告)号：US20210024594A1

公开(公告)日：2021-01-28

申请号：US16967919

申请日：2019-02-07

Applicant: StemRIM Inc. ,  OSAKA UNIVERSITY

Inventor： Katsuto TAMAI ,  Takashi SHIMBO ,  Takehiko YAMAZAKI

IPC: C07K14/47 ,  A61P17/06

Abstract: The present inventors discovered that an HMGB1 fragment peptide having a specific amino acid sequence exhibits an effect of suppressing erythema, scaling (desquamation), and thickening (infiltration) of the skin in an animal model of psoriasis. Based on these findings, pharmaceutical compositions for the prevention and/or treatment of psoriasis, which comprise the HMGB1 fragment peptide having the specific amino acid sequence are provided.