公开(公告)号：US20240003915A1

公开(公告)日：2024-01-04

申请号：US18271660

申请日：2022-01-05

申请人： NIIGATA UNIVERSITY

发明人： Hiroshi KAWACHI

IPC分类号： G01N33/68

CPC分类号： G01N33/6893 ,  G01N2333/4703 ,  G01N2800/347

摘要： The present invention provides use of an Ephrin-B as a marker for assisting in the diagnosis of nephrotic syndrome, a method for examining nephrotic syndrome comprising measuring the expression level of an Ephrin-B in the urine of a subject, and a diagnostic reagent for nephrotic syndrome comprising a substance that specifically binds to an Ephrin-B.

公开(公告)号：US20240002856A1

公开(公告)日：2024-01-04

申请号：US18037194

申请日：2021-11-15

申请人： NIIGATA UNIVERSITY

发明人： Akihiro SUGAI ,  Osamu ONODERA

IPC分类号： C12N15/113 ,  G01N33/50 ,  A61P25/28

CPC分类号： C12N15/1137 ,  G01N33/5023 ,  A61P25/28 ,  C12N2310/11

摘要： An antisense nucleic acid targeting intron 6 of TDP-43 mRNA, and including a nucleotide sequence complementary to a sequence consisting of 10 or more consecutive bases in a target sequence, wherein the target sequence is the 96th to 330th or 400th to 530th positions of a nucleotide sequence represented by SEQ ID NO:1.

公开(公告)号：US20230367621A1

公开(公告)日：2023-11-16

申请号：US18030612

申请日：2021-10-07

申请人： NIIGATA UNIVERSITY ,  Denka Company Limited

发明人： Shujiro OKUDA ,  Yu WATANABE ,  Hiroshi IZUTSU ,  Keisuke KODAMA

IPC分类号： G06F9/455

CPC分类号： G06F9/45558 ,  G06F2009/45562

摘要： A software providing apparatus that provides software for performing data processing concerning an oncogene, the software operating on a virtual machine and including a software module that executes data processing concerning an oncogene and setting information for determining an operation at a time when the software module executes the data processing, the software providing apparatus comprising a receiving unit that receives an instruction concerning providing the software to an at least one predetermined user group; and a generating unit that, when the instruction has been received, instructs an information processing apparatus which stores a template of a virtual machine including the software to duplicate the template of the virtual machine, hereby causing the information processing apparatus to generate a new virtual machine including software to be provided to the at least one predetermined user group.

公开(公告)号：US20230346823A1

公开(公告)日：2023-11-02

申请号：US18017013

申请日：2021-07-16

申请人： Niigata University ,  Denka Company Limited

发明人： Akihiko SAITO ,  Sawako GOTO ,  Yoshiaki HIRAYAMA

IPC分类号： A61K31/714 ,  A61K31/201 ,  A61P13/12

CPC分类号： A61K31/714 ,  A61K31/201 ,  A61P13/12

摘要： One object of the present invention is to provide an inhibitor for renal injuries induced by an iodinated contrast medium. In this invention, vitamin B12 or a pharmaceutically acceptable salt thereof is used.

公开(公告)号：US20230098487A1

公开(公告)日：2023-03-30

申请号：US17955129

申请日：2022-09-28

申请人： NIIGATA UNIVERSITY ,  SYSMEX CORPORATION

发明人： Takeshi SUZUKI ,  Masato MATSUDA ,  Masato MORIYAMA ,  Sho SHINOHARA ,  Keisuke KITANO ,  Tsukasa SUETAKE ,  Yutaka KOMIYAMA

IPC分类号： G01N33/86

摘要： A method for analyzing a cause of prolonging coagulation time of a blood specimen includes: adding a calcium solution to a first sample resulting from a first waiting time from mixing of a blood specimen from a subject and a measurement reagent for an activated partial thromboplastin time; obtaining a first coagulation time and/or a first parameter regarding a differential of a coagulation waveform, for the first sample; adding the calcium solution to a second sample resulting from a second waiting time, which is longer than the first waiting time, from mixing of the blood specimen from the subject and the measurement reagent; obtaining a second coagulation time and/or a second parameter regarding a differential of a coagulation waveform, for the second sample; and obtaining information regarding a cause of prolonging a coagulation time, on the basis of the first and second coagulation time and/or the first and second parameter.

公开(公告)号：US11485974B2

公开(公告)日：2022-11-01

申请号：US16869812

申请日：2020-05-08

申请人： STELIC INSTITUTE & CO. ,  (NATIONAL UNIVERSITY CORPORATION) NIIGATA UNIVERSITY

发明人： Hiroyuki Yoneyama ,  Kenji Suzuki

IPC分类号： C07H21/04 ,  C12N15/113 ,  A61K9/00 ,  A61K9/08 ,  A61K9/10 ,  A61K31/396 ,  A61K31/7088 ,  A61K31/7105 ,  A61K48/00 ,  A61P9/10 ,  A61P1/00 ,  A61P17/02 ,  A61P19/02 ,  A61K31/713

摘要： The present invention provides methods for retaining and expressing physiologically active substances in a target tissue-specific-manner, by administering the physiologically active substances to target submucous tissue. Specifically, the present inventors demonstrated that, when physiologically active substances were directly administered into submucous tissues without using a carrier, the physiologically active substances were effectively and safely retained at the administration sites over long periods without loss and diffusion, and produced the effect acting in a reservoir-like fashion. The physiologically active substances administered as described above were demonstrated to produce the therapeutic effect without having an influence on organs other than the administered organ.

公开(公告)号：US11414655B2

公开(公告)日：2022-08-16

申请号：US16642149

申请日：2018-08-31

申请人： Niigata University ,  Adeka Corporation

发明人： Tsutomu Sato ,  Tsutomu Hoshino ,  Toshihiko Takehana ,  Seiji Koike ,  Koichi Shigeno

IPC分类号： C12N9/90 ,  C12P7/02 ,  C12N1/20

摘要： An object of the present invention is to provide a method for preparing ambrein, which can easily and efficiently obtain the ambrein.
The object can be solved by a mutated tetraprenyl-β-curcumene cyclase wherein (1) a 4th amino acid residue of a DXDD motif, aspartic acid, is substituted with an amino acid other than aspartic acid, and (2) an amino acid adjacent to the N-terminus of a (A/S/G)RX(H/N)XXP motif is substituted with an amino acid other than tyrosine, or a 4th amino acid of the GXGX(G/A/P) motif is substituted with an amino acid other than leucine.

公开(公告)号：US20220175940A1

公开(公告)日：2022-06-09

申请号：US17593570

申请日：2020-02-27

申请人： NIIGATA UNIVERSITY

发明人： Eisaku KONDO

IPC分类号： A61K47/64 ,  C07K7/06 ,  A61K47/36 ,  A61K47/42 ,  A61P35/00

摘要： A peptide is composed of an amino acid sequence represented by general formula (I), and accumulates in cancer-associated fibroblasts. (In general formula (I), X11 is a peptide residue composed of an amino acid sequence of (a) or (b) below: (a) an amino acid sequence represented by any one of SEQ ID NOs: 1 to 4, (b) an amino acid sequence in which one or two amino acids have been deleted, substituted or added in an amino acid sequence represented by any one of SEQ ID NOs: 1 to 4; Y11 is a peptide linker composed of an amino acid residue of at least 1 but not more than 10 amino acids, wherein each amino acid residue is independently a glycine residue, a proline residue, a serine residue, a cysteine residue or a lysine residue; X12 is either a peptide residue composed of an amino acid sequence of (a) or (b) above, or a retro-inverso peptide residue thereof; and n11 represents an integer of at least 0 but not more than 9.) [Formula 1] X11—(Y11—X12)n11  (I)

公开(公告)号：US20190246457A1

公开(公告)日：2019-08-08

申请号：US16386621

申请日：2019-04-17

申请人： NGK INSULATORS, LTD. ,  National University Corporation Hokkaido University ,  National University Corporation Niigata University

发明人： Michiro AOKI ,  Yoshio Kondo ,  Tsuyoshi Totani ,  Atsushi Sakurai

IPC分类号： H05B3/12 ,  H05B3/00

CPC分类号： H05B3/12 ,  H05B3/0038 ,  H05B3/10 ,  H05B2203/032

摘要： An infrared heater includes a heater body and a casing. The heater body includes a heating element and a metamaterial structure capable of emitting infrared radiation having a peak wavelength of a non-Planck distribution when thermal energy is supplied from the heating element. The casing has an interior space in which the heater body is disposed and whose pressure is reducible. In addition, the casing includes an infrared radiation transmitting portion capable of transmitting the infrared radiation emitted by the metamaterial structure to an outside of the casing.

公开(公告)号：US20190216856A1

公开(公告)日：2019-07-18

申请号：US16329039

申请日：2017-08-30

申请人： NIIGATA UNIVERSITY

发明人： Takayoshi SHIMOHATA ,  Masato KANAZAWA

IPC分类号： A61K35/30 ,  A61K35/15 ,  A61K9/10 ,  C12N5/00 ,  A61P9/10 ,  C12N5/079 ,  C12N5/0786 ,  A61P19/00

CPC分类号： A61K35/30 ,  A61K9/10 ,  A61K35/15 ,  A61P9/10 ,  A61P19/00 ,  A61P43/00 ,  C12N5/0018 ,  C12N5/0622 ,  C12N5/0645

摘要： The present invention provides a method for producing a cell culture for promoting angiogenesis or axon outgrowth, particularly for the treatment of a cerebrovascular disease, an ischemic cardiac disease or traumatic brain injury and spinal cord injury, which comprises culturing a cell population containing microglia and/or monocytes under conditions of low oxygen concentration and/or low sugar concentration to produce the culture, a cell preparation obtained by the method, and a method for treating a cerebrovascular disease, an ischemic cardiac disease or traumatic cerebrospinal neuropathy by using the cell preparation.