公开(公告)号：US20220380420A1

公开(公告)日：2022-12-01

申请号：US17817084

申请日：2022-08-03

Applicant: StemRIM Inc. ,  OSAKA UNIVERSITY

Inventor： Katsuto TAMAI ,  Takashi SHIMBO ,  Takehiko YAMAZAKI

IPC: C07K14/47 ,  A61P17/06

Abstract: The present inventors discovered that an HMGB1 fragment peptide having a specific amino acid sequence exhibits an effect of suppressing erythema, scaling (desquamation), and thickening (infiltration) of the skin in an animal model of psoriasis. Based on these findings, pharmaceutical compositions for the prevention and/or treatment of psoriasis, which comprise the HMGB1 fragment peptide having the specific amino acid sequence are provided.

公开(公告)号：US20220265787A1

公开(公告)日：2022-08-25

申请号：US17631072

申请日：2020-07-30

Applicant: STEMRIM INC. ,  OSAKA UNIVERSITY

Inventor： Katsuto TAMAI ,  Takashi SHIMBO ,  Takehiko YAMAZAKI

IPC: A61K38/57 ,  A61K9/00 ,  A61P1/04 ,  A61P43/00 ,  C12N5/0775

Abstract: The present disclosure includes a composition for promoting growth or suppressing decrease of mesenchymal stem cells comprising serpin A3.

公开(公告)号：US20210024594A1

公开(公告)日：2021-01-28

申请号：US16967919

申请日：2019-02-07

Applicant: StemRIM Inc. ,  OSAKA UNIVERSITY

Inventor： Katsuto TAMAI ,  Takashi SHIMBO ,  Takehiko YAMAZAKI

IPC: C07K14/47 ,  A61P17/06

Abstract: The present inventors discovered that an HMGB1 fragment peptide having a specific amino acid sequence exhibits an effect of suppressing erythema, scaling (desquamation), and thickening (infiltration) of the skin in an animal model of psoriasis. Based on these findings, pharmaceutical compositions for the prevention and/or treatment of psoriasis, which comprise the HMGB1 fragment peptide having the specific amino acid sequence are provided.

公开(公告)号：US20210163552A1

公开(公告)日：2021-06-03

申请号：US16608139

申请日：2018-04-24

Applicant: SHIONOGI & CO., LTD. ,  StemRIM Inc.

Inventor： Yoichiro NIHASHI ,  Tomoyuki KAWACHI ,  Yukiko YAMATSU ,  Masataka FUMOTO ,  Takehiko YAMAZAKI

IPC: C07K14/47 ,  C12N5/077

Abstract: A peptide which can be utilized as an active ingredient of a composition for use in stimulation of migration of PDGFRα-positive cells, a composition for use in recruitment of bone marrow mesenchymal stem cells from bone marrow to peripheral blood, a composition for use in regeneration of tissues, or a composition for use in stimulation of migration of bone marrow-derived stromal cells is provided.

公开(公告)号：US20230173027A1

公开(公告)日：2023-06-08

申请号：US17919872

申请日：2021-04-19

Applicant: Shionogi & Co., Ltd. ,  StemRim Inc.

Inventor： Nao MATSUOKA ,  Shuichi HATANO ,  Yuya KUGA ,  Maki OKABE ,  Takehiko YAMAZAKI ,  Koichi YOKOTA

IPC: A61K38/19 ,  A61K47/12 ,  A61K47/26 ,  A61K47/02 ,  A61K9/19

CPC classification number: A61K38/19 ,  A61K47/12 ,  A61K47/26 ,  A61K47/02 ,  A61K9/19

Abstract: A pharmaceutical composition containing the substance according to any one of the following (a) to (c), an organic acid, a metal salt of an organic acid, and a sugar and/or a sugar alcohol, wherein when the pharmaceutical composition is dissolved in distilled water for injection, a pH of the pharmaceutical composition is 3.0 to 4.5, the substance according to any one of the following (a) to (c) can be stabilized;



(a) an HMGB1 fragment peptide comprising the amino acid sequence set forth in SEQ ID NO: 1 or an acid addition salt thereof;
(b) a peptide comprising an amino acid sequence having substitution, deletion, insertion or addition of one or more amino acids in the amino acid sequence set forth in SEQ ID NO: 1, and having an activity of stimulating migration of a cell, or an acid addition salt thereof; and
(c) a peptide comprising an amino acid sequence having about 80% or more of sequence identity to the amino acid sequence set forth in SEQ ID NO: 1, and having an activity of stimulating migration of a cell, or an acid addition salt thereof.

公开(公告)号：US20180055886A1

公开(公告)日：2018-03-01

申请号：US15674835

申请日：2017-08-11

Applicant: GENOMIX CO., LTD. ,  OSAKA UNIVERSITY

Inventor： Katsuto TAMAI ,  Takehiko YAMAZAKI ,  Takenao CHINO ,  Yasufumi KANEDA

IPC: A61K35/28 ,  C12N5/0775

CPC classification number: A61K35/28 ,  A61K2035/124 ,  C12N5/0663

Abstract: Biologically low invasive vessels are filled with biological factors that have the activity of mobilizing specific functional cells in the body. The vessels are indwelled in the body. After specific functional cells are mobilized into the vessels, the vessels are removed from the body to collect functional cell populations mobilized to the vessels. Alternatively, the cells are directly collected from the vessels indwelled in the body.