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公开(公告)号：US08076288B2
公开(公告)日：2011-12-13
申请号：US11206903
申请日：2005-08-17
申请人： Odile Esther Levy , Michael R. Hanley , Carolyn M. Jodka , Diana Y. Lewis , Christopher J. Soares , Soumitra S. Ghosh , Lawrence J. D'Souza , David G. Parkes , Christine M. Mack
发明人： Odile Esther Levy , Michael R. Hanley , Carolyn M. Jodka , Diana Y. Lewis , Christopher J. Soares , Soumitra S. Ghosh , Lawrence J. D'Souza , David G. Parkes , Christine M. Mack
CPC分类号： C07K14/605 , A61K9/0019 , A61K9/19 , A61K38/00 , C07K5/1013 , C07K5/1024 , C07K14/575 , C07K14/58
摘要： The present invention relates generally to novel, selectable hybrid polypeptides useful as agents for the treatment and prevention of metabolic diseases and disorders which can be alleviated by control plasma glucose levels, insulin levels, and/or insulin secretion, such as diabetes and diabetes-related conditions. Such conditions and disorders include, but are not limited to, hypertension, dyslipidemia, cardiovascular disease, eating disorders, insulin-resistance, obesity, and diabetes mellitus of any kind, including type 1, type 2, and gestational diabetes.
摘要翻译： 本发明一般涉及可用作治疗和预防代谢性疾病和病症的新颖的可选择的杂交多肽，其可通过控制血浆葡萄糖水平，胰岛素水平和/或胰岛素分泌而减轻，所述胰岛素分泌如糖尿病和糖尿病相关 条件。 这些病症和障碍包括但不限于高血压，血脂异常，心血管疾病，进食障碍，胰岛素抵抗，肥胖症和任何类型的糖尿病，包括1型，2型和妊娠糖尿病。
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公开(公告)号：US20120253023A1
公开(公告)日：2012-10-04
申请号：US13323608
申请日：2011-12-12
申请人： Odile Esther LEVY , Michael R. Hanley , Carolyn M. Jodka , Diana Y. Lewis , Christopher J. Soares , Soumitra S. Ghosh , Lawrence J. D'Souza , David G. Parkes , Christine M. Mack
发明人： Odile Esther LEVY , Michael R. Hanley , Carolyn M. Jodka , Diana Y. Lewis , Christopher J. Soares , Soumitra S. Ghosh , Lawrence J. D'Souza , David G. Parkes , Christine M. Mack
IPC分类号： C07K19/00
CPC分类号： C07K14/605 , A61K9/0019 , A61K9/19 , A61K38/00 , C07K5/1013 , C07K5/1024 , C07K14/575 , C07K14/58
摘要： The present invention relates generally to novel, selectable hybrid polypeptides useful as agents for the treatment and prevention of metabolic diseases and disorders which can be alleviated by control plasma glucose levels, insulin levels, and/or insulin secretion, such as diabetes and diabetes-related conditions. Such conditions and disorders include, but are not limited to, hypertension, dyslipidemia, cardiovascular disease, eating disorders, insulin-resistance, obesity, and diabetes mellitus of any kind, including type 1, type 2, and gestational diabetes.
摘要翻译： 本发明一般涉及可用作治疗和预防代谢性疾病和病症的新颖的可选择的杂交多肽，其可通过控制血浆葡萄糖水平，胰岛素水平和/或胰岛素分泌而减轻，所述胰岛素分泌如糖尿病和糖尿病相关 条件。 这些病症和障碍包括但不限于高血压，血脂异常，心血管疾病，进食障碍，胰岛素抵抗，肥胖症和任何类型的糖尿病，包括1型，2型和妊娠糖尿病。
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公开(公告)号：US20090286723A1
公开(公告)日：2009-11-19
申请号：US12063420
申请日：2006-08-11
申请人： Odile Esther Levy , Michael R. Hanley , Carolyn M. Jodka , Diana Y. Lewis , Christopher J. Soares , Soumitra S. Ghosh , Lawrence J. D'Souza , David G. Parkes , Christine M. Mack , Behrouz Bruce Forood
发明人： Odile Esther Levy , Michael R. Hanley , Carolyn M. Jodka , Diana Y. Lewis , Christopher J. Soares , Soumitra S. Ghosh , Lawrence J. D'Souza , David G. Parkes , Christine M. Mack , Behrouz Bruce Forood
IPC分类号： A61K38/22 , C07K2/00 , C07K14/585 , C07K14/605 , C07K14/575 , A61P3/10 , A61P9/00
CPC分类号： C07K14/575 , A61K38/00 , C07K2319/00
摘要： The present invention relates generally to novel, selectable hybrid polypeptides useful as agents for the treatment and prevention of metabolic diseases and disorders which can be alleviated by control plasma glucose levels, insulin levels, and/or insulin secretion, such as diabetes and diabetes-related conditions. Such conditions and disorders include, but are not limited to, hypertension, dyslipidemia, cardiovascular disease, eating disorders, insulin-resistance, obesity, and diabetes mellitus of any kind, including type 1, type 2, and gestational diabetes.
摘要翻译： 本发明一般涉及可用作治疗和预防代谢性疾病和病症的新颖的可选择的杂交多肽，其可通过控制血浆葡萄糖水平，胰岛素水平和/或胰岛素分泌而减轻，所述胰岛素分泌如糖尿病和糖尿病相关 条件。 这些病症和障碍包括但不限于高血压，血脂异常，心血管疾病，进食障碍，胰岛素抵抗，肥胖症和任何类型的糖尿病，包括1型，2型和妊娠糖尿病。
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公开(公告)号：US08895498B2
公开(公告)日：2014-11-25
申请号：US13591677
申请日：2012-08-22
申请人： Odile Esther Levy , Alain D. Baron , Lawrence J. D'Souza , Mary Erickson , Soumitra G. Ghosh , Michael R. Hanley , Samuel Janssen , Carolyn M. Jodka , Diana Y. Lewis , Christine M. Mack , David G. Parkes , Richard A. Pittner , Christopher J. Soares , Ved Srivastava , Andrew A. Young , Thao Le
发明人： Odile Esther Levy , Alain D. Baron , Lawrence J. D'Souza , Mary Erickson , Soumitra G. Ghosh , Michael R. Hanley , Samuel Janssen , Carolyn M. Jodka , Diana Y. Lewis , Christine M. Mack , David G. Parkes , Richard A. Pittner , Christopher J. Soares , Ved Srivastava , Andrew A. Young , Thao Le
IPC分类号： A61K38/00 , A61P3/10 , C07K7/06 , C07K14/575
CPC分类号： C07K14/575 , A61K38/00 , C07K7/06 , C07K14/605
摘要： The present invention relates generally to novel GIP analogs and GIP hybrid polypeptides with selectable properties, useful as agents for the treatment and prevention of metabolic diseases and disorders, for example those which can be alleviated by control plasma glucose levels, insulin levels, and/or insulin secretion, positive inotropic effects, reduction of catabolic effects, slowing of gastric emptying. Such conditions and disorders include, but are not limited to, hypertension, dyslipidemia, cardiovascular disease, eating disorders, critical care, insulin-resistance, obesity, and diabetes mellitus of any kind, including type 1, type 2, and gestational diabetes.
摘要翻译： 本发明一般涉及具有可选性质的新型GIP类似物和GIP杂合多肽，其可用作治疗和预防代谢性疾病和病症的药剂，例如可通过控制血浆葡萄糖水平，胰岛素水平和/或 胰岛素分泌，正性肌力作用，分解代谢作用降低，胃排空减慢。 这些病症和障碍包括但不限于高血压，血脂异常，心血管疾病，饮食失调，重症监护，胰岛素抵抗，肥胖症和任何类型的糖尿病，包括1型，2型和妊娠糖尿病。
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公开(公告)号：US20130137631A1
公开(公告)日：2013-05-30
申请号：US13591677
申请日：2012-08-22
申请人： Odile Esther LEVY , Alain D. Baron , Lawrence J. D'Souza , Mary Erickson , Soumitra G. Ghosh , Michael R. Hanley , Samuel Janssen , Carolyn M. Jodka , Diana Y. Lewis , Christine M. Mack , David G. Parkes , Richard A. Pittner , Christopher J. Soares , Ved Srivastava , Andrew A. Young , Thao Le
发明人： Odile Esther LEVY , Alain D. Baron , Lawrence J. D'Souza , Mary Erickson , Soumitra G. Ghosh , Michael R. Hanley , Samuel Janssen , Carolyn M. Jodka , Diana Y. Lewis , Christine M. Mack , David G. Parkes , Richard A. Pittner , Christopher J. Soares , Ved Srivastava , Andrew A. Young , Thao Le
IPC分类号： C07K14/575 , C07K7/06
CPC分类号： C07K14/575 , A61K38/00 , C07K7/06 , C07K14/605
摘要： The present invention relates generally to novel GIP analogs and GIP hybrid polypeptides with selectable properties, useful as agents for the treatment and prevention of metabolic diseases and disorders, for example those which can be alleviated by control plasma glucose levels, insulin levels, and/or insulin secretion, positive inotropic effects, reduction of catabolic effects, slowing of gastric emptying. Such conditions and disorders include, but are not limited to, hypertension, dyslipidemia, cardiovascular disease, eating disorders, critical care, insulin-resistance, obesity, and diabetes mellitus of any kind, including type 1, type 2, and gestational diabetes.
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公开(公告)号：US20140066370A1
公开(公告)日：2014-03-06
申请号：US13511201
申请日：2010-11-23
申请人： Behrouz Bruce Forood , Soumitra S. Ghosh , James L. Trevaskis , Chengzao Sun , Odile Esther Levy , Lawrence J. D'Souza , Christopher J. Soares
发明人： Behrouz Bruce Forood , Soumitra S. Ghosh , James L. Trevaskis , Chengzao Sun , Odile Esther Levy , Lawrence J. D'Souza , Christopher J. Soares
IPC分类号： C07K14/605
CPC分类号： C07K14/605 , A61K38/00 , A61K47/54 , A61K47/542 , A61K47/554 , A61K47/60 , A61K47/64 , A61K47/643 , C07K14/575 , C07K14/57563 , C07K14/585
摘要： The disclosure provides Polypeptide Conjugates with multiple improved pharmacological and pharmacokinetic properties and their use in treating various diseases and conditions, such as diabetes and/or obesity.
摘要翻译： 本公开提供多肽缀合物具有多种改善的药理学和药代动力学性质及其在治疗各种疾病和病症如糖尿病和/或肥胖症中的用途。
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17.发明授权Peptide-peptidase-inhibitor conjugates and methods of making and using same 失效肽 - 肽酶 - 抑制剂缀合物及其制备和使用方法公开(公告)号：US08598314B2
公开(公告)日：2013-12-03
申请号：US12680539
申请日：2008-09-26
申请人： Soumitra S. Ghosh , Josue Alfaro-Lopez , Lawrence J. D'Souza , Odile Esther Levy , Qing Lin , Christopher J. Soares
发明人： Soumitra S. Ghosh , Josue Alfaro-Lopez , Lawrence J. D'Souza , Odile Esther Levy , Qing Lin , Christopher J. Soares
CPC分类号： A61K47/64 , A61K47/545 , A61K47/55
摘要： Peptide-peptidase inhibitor conjugate molecules and methods of manufacture thereof are disclosed. These conjugate molecules are useful as agents for the treatment and prevention of metabolic and cardiovascular diseases, disorders, and conditions. Such diseases, conditions and disorders include, but are not limited to, hypertension, dyslipidemia, cardiovascular disease, eating disorders, insulin-resistance, obesity, and diabetes mellitus of any kind, and other diabetes-related disorders.
摘要翻译： 公开了肽肽酶抑制剂缀合物分子及其制备方法。 这些缀合物分子可用作治疗和预防代谢和心血管疾病，病症和病症的药剂。 这些疾病，病症和障碍包括但不限于高血压，血脂异常，心血管疾病，进食障碍，胰岛素抵抗，肥胖症和任何类型的糖尿病以及其它与糖尿病有关的疾病。
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18.发明申请PEPTIDE-PEPTIDASE-INHIBITOR CONJUGATES AND METHODS OF MAKING AND USING SAME 失效肽 - 肽抑制剂结合物及其制备方法和使用方法公开(公告)号：US20100286365A1
公开(公告)日：2010-11-11
申请号：US12680539
申请日：2008-09-26
申请人： Soumitra S. Ghosh , Josue Alfaro-Lopez , Lawrence J. D'Souza , Odile Esther Levy , Qing Lin , Christopher J. Soares
发明人： Soumitra S. Ghosh , Josue Alfaro-Lopez , Lawrence J. D'Souza , Odile Esther Levy , Qing Lin , Christopher J. Soares
IPC分类号： C07K1/10
CPC分类号： A61K47/64 , A61K47/545 , A61K47/55
摘要： Peptide-peptidase inhibitor conjugate molecules and methods of manufacture thereof are disclosed. These conjugate molecules are useful as agents for the treatment and prevention of metabolic and cardiovascular diseases, disorders, and conditions. Such diseases, conditions and disorders include, but are not limited to, hypertension, dyslipidemia, cardiovascular disease, eating disorders, insulin-resistance, obesity, and diabetes mellitus of any kind, and other diabetes-related disorders.
摘要翻译： 公开了肽肽酶抑制剂缀合物分子及其制备方法。 这些缀合物分子可用作治疗和预防代谢和心血管疾病，病症和病症的药剂。 这些疾病，病症和障碍包括但不限于高血压，血脂异常，心血管疾病，进食障碍，胰岛素抵抗，肥胖症和任何类型的糖尿病以及其它与糖尿病有关的疾病。
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公开(公告)号：US08759295B2
公开(公告)日：2014-06-24
申请号：US12785396
申请日：2010-05-21
申请人： Soumitra S. Ghosh , Josue Alfaro-Lopez , Lawrence J. D'Souza , Odile Esther Levy , Qing Lin , Christopher J. Soares
发明人： Soumitra S. Ghosh , Josue Alfaro-Lopez , Lawrence J. D'Souza , Odile Esther Levy , Qing Lin , Christopher J. Soares
IPC分类号： A61K38/26 , C07K14/605 , C07K19/00 , A61P3/10 , A61P9/00 , A61P9/04 , A61P9/08 , A61P9/10 , A61P9/12
CPC分类号： A61K47/48246 , A61K47/545 , A61K47/55 , A61K47/64
摘要： Peptide-peptidase inhibitor conjugate molecules are disclosed. These conjugate molecules are useful as agents for the treatment and prevention of metabolic and cardiovascular diseases, disorders, and conditions. Such diseases, conditions and disorders include, but are not limited to, hypertension, dyslipidemia, cardiovascular disease, eating disorders, insulin-resistance, obesity, and diabetes mellitus of any kind, and other diabetes-related disorders.
摘要翻译： 公开了肽 - 肽酶抑制剂缀合物分子。 这些缀合物分子可用作治疗和预防代谢和心血管疾病，病症和病症的药剂。 这些疾病，病症和障碍包括但不限于高血压，血脂异常，心血管疾病，进食障碍，胰岛素抵抗，肥胖症和任何类型的糖尿病以及其它与糖尿病有关的疾病。
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公开(公告)号：US20090186817A1
公开(公告)日：2009-07-23
申请号：US12293389
申请日：2007-03-21
申请人： Soumitra S. Ghosh , Josue Alfaro-Lopez , Lawrence J. D'Souza , Odile Esther Levy , Qing Lin , Christopher J. Soares
发明人： Soumitra S. Ghosh , Josue Alfaro-Lopez , Lawrence J. D'Souza , Odile Esther Levy , Qing Lin , Christopher J. Soares
IPC分类号： A61K38/22 , C07K2/00 , C07K14/575
CPC分类号： A61K47/545 , A61K47/55 , A61K47/64
摘要： Peptide-peptidase inhibitor conjugate molecules are disclosed. These conjugate molecules are useful as agents for the treatment and prevention of metabolic and cardiovascular diseases, disorders, and conditions. Such diseases, conditions and disorders include, but are not limited to, hypertension, dyslipidemia, cardiovascular disease, eating disorders, insulin-resistance, obesity, and diabetes mellitus of any kind, and other diabetes-related disorders.
摘要翻译： 公开了肽 - 肽酶抑制剂缀合物分子。 这些缀合物分子可用作治疗和预防代谢和心血管疾病，病症和病症的药剂。 这些疾病，病症和障碍包括但不限于高血压，血脂异常，心血管疾病，进食障碍，胰岛素抵抗，肥胖症和任何类型的糖尿病以及其它与糖尿病有关的疾病。
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