公开(公告)号：US20170290922A1

公开(公告)日：2017-10-12

申请号：US15507639

申请日：2015-08-31

Applicant: Susavion Biosciences, Inc.

Inventor： Laura L. Eggink ,  J. Kenneth Hoober

IPC: A61K47/48 ,  C07K14/52 ,  G01N33/574 ,  C07K14/47 ,  A61K38/19 ,  A61K39/00

CPC classification number: A61K47/641 ,  A61K38/00 ,  A61K38/08 ,  A61K38/19 ,  A61K39/00 ,  A61K47/48246 ,  A61K47/65 ,  C07K14/47 ,  C07K14/52 ,  C07K19/00 ,  C07K2319/02 ,  G01N33/574

Abstract: Polypeptides, such as a multi-valent polypeptide designated svD2, useful in pharmaceutical compositions for stimulation of the adaptive arm of the immune system. svD2 demonstrated in vivo activity in a syngeneic mouse model. svD2 is biologically active at nanomolar concentrations. These properties are believed to result as a consequence of the ability of svD2 to cross-link cell-surface receptors.

公开(公告)号：US09687560B2

公开(公告)日：2017-06-27

申请号：US14404928

申请日：2013-05-31

Applicant: LG Household & Health Care Ltd.

Inventor： Seol Hoon Lee

IPC: A61K47/48 ,  C07K14/43 ,  C07K14/435 ,  C07K7/08 ,  A61K38/00

CPC classification number: A61K47/48246 ,  A61K38/00 ,  A61K47/64 ,  C07K7/08 ,  C07K14/435 ,  C07K2319/00 ,  C07K2319/10

Abstract: The present invention relates to a skin-permeating peptide, and more particularly, the present invention relates to an isolated peptide capable of permeating the skin to deliver a drug to the skin, to an isolated polynucleotide coding the peptide, to a composition for transdermal delivery comprising the peptide, and to a peptide/cargo composite comprising the peptide and cargo.

公开(公告)号：US09629919B2

公开(公告)日：2017-04-25

申请号：US15054266

申请日：2016-02-26

Applicant: CEDARS-SINAI MEDICAL CENTER

Inventor： Rameshwar Patil ,  Eggehard Holler ,  Keith L. Black ,  Julia Y. Ljubimova

IPC: A61K47/48 ,  C07K16/28 ,  C07K16/30 ,  A61K31/4188 ,  A61K31/425

CPC classification number: A61K47/593 ,  A61K31/4188 ,  A61K31/425 ,  A61K47/48061 ,  A61K47/48215 ,  A61K47/48246 ,  A61K47/48338 ,  A61K47/48384 ,  A61K47/48561 ,  A61K47/48584 ,  A61K47/48623 ,  A61K47/48669 ,  A61K47/48692 ,  A61K47/545 ,  A61K47/60 ,  A61K47/64 ,  A61K47/65 ,  A61K47/6803 ,  A61K47/6849 ,  A61K47/6851 ,  A61K47/6855 ,  A61K47/6865 ,  A61K47/6877 ,  A61K47/6883 ,  A61K47/6889 ,  A61K47/6898 ,  C07K16/2881 ,  C07K16/3015 ,  C07K16/3053 ,  C07K2317/24 ,  C07K2317/77

Abstract: The present invention relates to methods of drug delivery for the treatment of a condition or disease, such as cancer. In one embodiment, the invention provides a method of preparing a multifunctional nanoconjugate of temozolomide (TMZ) by conjugating TMZ in its hydrazide form to a polymalic acid platform. In another embodiment, the polymalic acid platform is conjugated to a monoclonal antibody to transferrin receptor, a trileucine (LLL) moiety, and/or a polyethylene glycol (PEG) moiety. The present invention relates to methods of drug delivery for the treatment of a condition or disease, such as cancer. In one embodiment, the invention provides a method of preparing a multifunctional nanoconjugate of temozolomide (TMZ) by conjugating TMZ in its hydrazide form to a polymalic acid platform. In another embodiment, the polymalic acid platform is conjugated to a monoclonal antibody to transferrin receptor, a trileucine (LLL) moiety, and/or a polyethylene glycol (PEG) moiety.

公开(公告)号：US09603891B2

公开(公告)日：2017-03-28

申请号：US14741949

申请日：2015-06-17

Applicant: Chonnam National University Hospital

Inventor： In-Ho Bae ,  Dae Sung Park ,  So Youn Lee ,  Eun Jae Jang ,  Kyung Seob Lim ,  Myung Ho Jeong

IPC: A61K38/08 ,  C07K7/06 ,  A61K31/4745 ,  A61L31/08 ,  A61L31/16 ,  A61K47/48

CPC classification number: A61K38/08 ,  A61K31/4745 ,  A61K47/48246 ,  A61K47/64 ,  A61L31/08 ,  A61L31/16 ,  A61L2300/412 ,  A61L2300/606 ,  A61L2400/18 ,  A61L2420/00 ,  C07K7/06

Abstract: Provided are a peptide compound prepared by additional synthesis in a drug having an effect of inhibiting restenosis, a composition for inhibiting restenosis and promoting re-endothelialization including the peptide compound, and a stent having a surface coated by using the composition, in order to overcome a restenosis problem in the stent.

公开(公告)号：US09545449B2

公开(公告)日：2017-01-17

申请号：US14400190

申请日：2013-05-13

Applicant: Advanced Proteome Therapeutics Inc.

Inventor： Alexander Krantz

IPC: A61K38/00 ,  A61K47/48 ,  A61K38/17 ,  A61K38/38 ,  A61K38/40 ,  A61K45/06 ,  C07K14/435

CPC classification number: A61K47/48246 ,  A61K38/17 ,  A61K38/38 ,  A61K38/40 ,  A61K45/06 ,  A61K47/64 ,  C07K14/435

Abstract: The present invention relates to the formation of protein conjugates from proteins chemically modified for linkage to (1) anticancer drug pharmacophores, (2) ligands to biomarkers on cancer cell surfaces, (3) and/or another protein molecule. It provides and specifies new compositions, methods and combinations for tumor, and tumor vasculature targeting and cancer treatment.

Abstract translation: 本发明涉及从化学修饰用于连接到（1）抗癌药物载体的蛋白质的蛋白质的形成，（2）癌细胞表面上生物标志物的配体，（3）和/或另一种蛋白质分子。 它提供并指定肿瘤的新组合物，方法和组合以及肿瘤血管系统靶向和癌症治疗。

公开(公告)号：US09504745B2

公开(公告)日：2016-11-29

申请号：US14100892

申请日：2013-12-09

Applicant: The Board of Regents of the University of Oklahoma

Inventor： Roger G. Harrison, Jr. ,  Daniel E. Resasco ,  Luis Filipe Ferreira Neves

IPC: A61K41/00 ,  A61N1/40 ,  A61K38/17 ,  A61K45/06 ,  A61K47/48 ,  B82Y5/00 ,  A61N2/02 ,  A61N5/06

CPC classification number: A61K41/0052 ,  A61K38/1709 ,  A61K45/06 ,  A61K47/48215 ,  A61K47/48246 ,  A61K47/48869 ,  A61K47/48884 ,  A61K47/60 ,  A61K47/64 ,  A61K47/6925 ,  A61K47/6929 ,  A61N1/406 ,  A61N2/02 ,  A61N5/062 ,  A61N2005/0659 ,  B82Y5/00 ,  A61K2300/00

Abstract: Compositions for detecting and/or destroying cancer tumors and/or cancer cells via photodynamic therapy are disclosed, as well as methods of use thereof. The compositions comprise a linking protein or peptide attached to or otherwise physically associated with a carbon nanotube to form a targeted protein-carbon nanotube complex.

Abstract translation: 公开了通过光动力疗法检测和/或破坏癌肿瘤和/或癌细胞的组合物，以及其使用方法。 组合物包含与碳纳米管连接或以其他方式物理相联系的连接蛋白或肽，以形成靶向的蛋白质 - 碳纳米管复合物。

公开(公告)号：US09439975B2

公开(公告)日：2016-09-13

申请号：US14128037

申请日：2012-06-20

Applicant: Michel De Waard

Inventor： Michel De Waard

IPC: A61K47/48 ,  C07K14/435

CPC classification number: A61K47/48246 ,  A61K47/64 ,  C07K14/43522

Abstract: The invention relates to small cell penetrating peptides (CPP) derived from the scorpion toxin maurocalcine and to their use as vectors for the intracellular delivery of various drugs and agents.

Abstract translation: 本发明涉及从蝎毒素月桂酰胺衍生的小细胞穿透肽（CPP）及其作为各种药物和试剂的细胞内递送载体的用途。

公开(公告)号：US09408921B2

公开(公告)日：2016-08-09

申请号：US14189185

申请日：2014-02-25

Applicant: Brandeis University

Inventor： Yuan Gao ,  Yi Kuang ,  Bing Xu

IPC: A61K47/48 ,  C07D305/14 ,  C07F9/12 ,  C07F9/655 ,  C07K5/107

CPC classification number: A61K47/48246 ,  A61K47/64 ,  C07D305/14 ,  C07F9/12 ,  C07F9/65512 ,  C07F9/6552 ,  C07K5/1016

Abstract: Disclosed is a general methodology to create nanofibers of therapeutic molecules that have a dual role, as both the delivery vehicle and the drug itself. It is shown that with proper molecular design, the integration of enzymatic reaction and self-assembly provides a powerful method to create molecular hydrogels of clinically-used therapeutics without compromising their bioactivities. In addition, the results disclosed herein demonstrate enzyme-instructed self-assembly as a facile strategy for generating the supramolecular hydrogels of molecules that inherently have poor solubility in water. For example, by covalently connecting paclitaxel with a motif that is prone to self-assemble, a hydrogel of paclitaxel can be formed without compromising the activity of the paclitaxel.

Abstract translation: 公开了一种制备具有双重作用的治疗分子的纳米纤维的一般方法，作为递送载体和药物本身。 已经表明，通过适当的分子设计，酶反应和自组装的整合提供了一种有效的方法来产生临床使用的治疗剂的分子水凝胶而不损害其生物活性。 此外，本文公开的结果表明酶指导的自组装作为产生在水中固有地具有差的溶解度的分子的超分子水凝胶的简单策略。 例如，通过将紫杉醇与易于自组装的基序共价连接，可以形成紫杉醇的水凝胶而不损害紫杉醇的活性。

公开(公告)号：US09381178B2

公开(公告)日：2016-07-05

申请号：US14684218

申请日：2015-04-10

Applicant: AF Chemicals, LLC

Inventor： Michael Kelner

IPC: A61K31/352 ,  A61K31/19 ,  A61K47/48 ,  A61K31/122

CPC classification number: A61K31/122 ,  A61K31/19 ,  A61K47/481 ,  A61K47/48246 ,  A61K47/48261 ,  A61K47/48338 ,  A61K47/48369 ,  A61K47/551 ,  A61K47/554 ,  A61K47/62 ,  A61K47/642 ,  A61K47/6803 ,  A61K47/6889

Abstract: In an embodiment of the invention, a composition for treating a cell population comprises an Affinity Medicant Conjugate (AMC). The medicant moiety can be a toxin including an acylfulvene or a drug moiety. The affinity moiety can be an antibody, a binding protein, a steroid, a lipid, a growth factor, a protein, a peptide or non peptidic. The affinity moiety can be covalently bound to the medicant via a linker. Novel linkers that can be directed to cysteine, arginine or lysine residues based on solution pH allow greater flexibility in preserving and/or generating specific epitopes in the AMC.

Abstract translation: 在本发明的一个实施方案中，用于治疗细胞群的组合物包含亲和药剂缀合物（AMC）。 药物部分可以是包括酰基富烯或药物部分的毒素。 亲和部分可以是抗体，结合蛋白，类固醇，脂质，生长因子，蛋白质，肽或非肽。 亲和部分可以通过接头与药物共价结合。 基于溶液pH可引导到半胱氨酸，精氨酸或赖氨酸残基的新型接头允许在AMC中保存和/或产生特异性表位的更大灵活性。

公开(公告)号：US20160184398A1

公开(公告)日：2016-06-30

申请号：US14812681

申请日：2015-07-29

Applicant: United States Department of Health and Human Services

Inventor： Raj K. Puri

IPC: A61K38/20 ,  A61K31/7068

CPC classification number: A61K38/2026 ,  A61K31/513 ,  A61K31/519 ,  A61K31/555 ,  A61K31/704 ,  A61K31/7068 ,  A61K33/24 ,  A61K45/06 ,  A61K47/48246 ,  A61K47/642 ,  A61K49/0008 ,  A61K2300/00

Abstract: The present invention combines a targeted cargo protein with an active agent for the treatment of a disease or condition.