公开(公告)号：US20220002347A1

公开(公告)日：2022-01-06

申请号：US17340731

申请日：2021-06-07

Applicant: ONKURE, INC.

Inventor： Anthony D. Piscopio ,  Xiaoyong Fu ,  Feng Shi ,  Huayan Liu ,  Zhifeng Li

IPC: C07K11/02 ,  C07K5/097 ,  C07D498/06 ,  C07D513/06 ,  C07D513/14 ,  C07K11/00 ,  A61K38/15 ,  C07K1/113

Abstract: Processes for preparing compounds of Formula (1) and Formula (2) are described, wherein X, Y, Z, R1-R7, L and n are defined herein. Intermediates useful in the preparation of the compounds of Formula (1) and Formula (2) are also described.

公开(公告)号：US20200317693A1

公开(公告)日：2020-10-08

申请号：US16303217

申请日：2017-05-18

Applicant: OnKure, Inc.

Inventor： Anthony D. Piscopio

IPC: C07D513/08

Abstract: The present invention provides a novel macrocyclic prodrug compound of general Formula (I), a pharmaceutical composition comprising a compound of Formula (I), and a method for treating diseases mediated by HDAC enzymes by administering a compound of Formula (I), wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, A and Z are defined herein.

公开(公告)号：US10689419B2

公开(公告)日：2020-06-23

申请号：US16127399

申请日：2018-09-11

Applicant: ONKURE, INC.

Inventor： Anthony D. Piscopio ,  Xiaoyong Fu ,  Feng Shi ,  Huayan Liu ,  Zhifeng Li

IPC: A61K38/15 ,  C07K11/00 ,  C07K11/02 ,  C07K5/097 ,  C07D498/06 ,  C07D513/06 ,  C07D513/14 ,  C07K1/113

Abstract: Processes for preparing compounds of Formula (1) and Formula (2) are described, wherein X, Y, Z, R1-R7, L and n are defined herein. Intermediates useful in the preparation of the compounds of Formula (1) and Formula (2) are also described.

公开(公告)号：US10100089B2

公开(公告)日：2018-10-16

申请号：US15313800

申请日：2015-05-27

Applicant: ONKURE, INC.

Inventor： Anthony D. Piscopio ,  Xiaoyong Fu ,  Feng Shi ,  Huayan Liu ,  Zhifeng Li

IPC: C07K1/113 ,  C07K11/02

Abstract: Processes for preparing compounds of Formula (1) and Formula (2) are described, wherein X, Y, Z, R1-R7, L and n are defined herein. Intermediates useful in the preparation of the compounds of Formula (1) and Formula (2) are also described.

公开(公告)号：US20170183382A1

公开(公告)日：2017-06-29

申请号：US15313800

申请日：2015-05-27

Applicant: ONKURE, INC.

Inventor： Anthony D. Piscopio ,  Xiaoyong Fu ,  Feng Shi ,  Huayan Liu ,  Zhifeng Li

IPC: C07K11/02

CPC classification number: C07K11/02 ,  C07D498/06 ,  C07D513/06 ,  C07D513/14 ,  C07K1/113 ,  C07K5/0821

Abstract: Processes for preparing compounds of Formula (1) and Formula (2) are described, wherein X, Y, Z, R1-R7, L and n are defined herein. Intermediates useful in the preparation of the compounds of Formula (1) and Formula (2) are also described.