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1.发明公开公开(公告)号：US20230382946A1
公开(公告)日：2023-11-30
申请号：US18322699
申请日：2023-05-24
申请人： Changzhou University
发明人： Hua-Dong Xu , Mei-Hua Shen , Yu-Jiao Wang , Yong Wang , Ying Zhou , Xiao-Qian Liu , Jia Guo , Mingxing Ouyang , Linhong Deng
CPC分类号： C07K1/10 , C07K1/1077 , C07K1/113
摘要： A polypeptide or protein directional modification method based on sulfhydryl-alkenyl azide coupling is provided. The method uses a sulfhydryl group-containing compound and a compound containing alkenyl azide group as reactants to generate an amino acid containing β-carbonyl sulfide, a polypeptide containing β-carbonyl sulfide and a protein bioconjugate containing β-carbonyl sulfide, thereby achieving a chemical modification. The method is mild in conditions and wide in solvent selectivity, a reaction temperature is in a range of 37 degrees Celsius (° C.) to 40° C., and a reaction time is in a range of 10 minutes to 48 hours. The method is promising in preparing functional polypeptides or functional proteins, protein labeling, and biological medicine.
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公开(公告)号：US20230357357A1
公开(公告)日：2023-11-09
申请号：US18214282
申请日：2023-06-26
发明人： Shunhai Wang , Ning Li , Hunter Chen , Amardeep Singh Bhupender Bhalla , Shawn Lawrence , Amy Johnson , Meghan Casey , Jaimie Grapel
IPC分类号： C07K14/71 , C12N5/00 , C07K16/28 , C07K1/16 , G01N30/80 , C07K1/18 , C07K16/22 , C07K1/22 , C12P21/02 , A61K38/18 , C07K1/36 , C12P21/06 , C07K1/113 , C12N15/66 , G01N30/02
CPC分类号： C07K14/71 , C12N5/0018 , C07K16/283 , C07K1/16 , G01N30/80 , C12N5/0031 , C07K1/18 , C07K16/22 , C07K1/22 , C12P21/02 , A61K38/1866 , C07K1/36 , C12P21/06 , C07K1/113 , C12N15/66 , C07K2319/33 , C07K2319/30 , C07K2317/622 , G01N2030/027 , C12N2800/10
摘要： The present disclosure pertains to compositions comprising anti-VEGF proteins and methods for producing such compositions.
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公开(公告)号：US20190185531A1
公开(公告)日：2019-06-20
申请号：US16319199
申请日：2017-07-21
发明人： Amy KEATING , Justin Michael JENSON
IPC分类号： C07K14/47 , A61P35/00 , C07K1/113 , G01N33/574
CPC分类号： C07K14/4747 , A61K38/00 , A61P35/00 , C07K1/113 , C07K14/00 , C07K14/395 , C07K2319/00 , C07K2319/10 , C07K2319/42 , C07K2319/43 , G01N33/50 , G01N33/574 , G01N2333/4703
摘要： Provided herein are compounds comprising peptides that bind Bfl-1. Also provided are compositions containing these peptides and methods of using such peptides in the treatment of cancer that include administering to a subject one of the peptides.
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公开(公告)号：US20180305400A1
公开(公告)日：2018-10-25
申请号：US15917560
申请日：2018-03-09
IPC分类号： C07K1/00 , C12N15/10 , C07K14/47 , C07K14/00 , C07K1/113 , C07K1/10 , C07K1/04 , A61K38/02 , A61K38/00
CPC分类号： C07K1/00 , A61K38/00 , A61K38/02 , C07K1/04 , C07K1/047 , C07K1/10 , C07K1/113 , C07K14/001 , C07K14/4746 , C12N15/1093
摘要： The present invention provides novel stabilized crosslinked compounds having secondary structure motifs, libraries of these novel compounds, and methods for the synthesis of these compounds libraries thereof. The synthesis of these novel stabilized compounds involves (1) synthesizing a peptide from a selected number of natural or non-natural amino acids, wherein said peptide comprises at least two moieties capable of undergoing reaction to promote carbon-carbon bond formation; and (2) contacting said peptide with a reagent to generate at least one crosslinker and to effect stabilization of a secondary structure motif. The present invention, in a preferred embodiment, provides stabilized p53 donor helical peptides. Additionally, the present invention provides methods for disrupting the p53/MDM2 binding interaction comprising (1) providing a crosslinked stabilized α-helical structure; and (2) contacting said crosslinked stabilized α-helical structure with MDM2.
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公开(公告)号：US10081654B2
公开(公告)日：2018-09-25
申请号：US14775315
申请日：2014-03-13
IPC分类号： A61K38/12 , A61K38/00 , C07K5/00 , C07K7/00 , C07K16/00 , C07K17/00 , C07K7/08 , C07K1/04 , C07K7/06 , C07D205/04 , C07D207/16 , C07K1/113
CPC分类号： C07K7/08 , A61K38/00 , C07D205/04 , C07D207/16 , C07K1/04 , C07K1/113 , C07K7/06
摘要： The present invention provides stapled polypeptides of the Formulae (I) and (VI): (I) (VI) and salts thereof; wherein the groups ; R1a, R1b, R1c, R2a, R3a, R2b, R3b, R4a, R4b, RA, RZ, L1a, L1b, L2, L3, XAA, v, w, p, m, s, n, t, and q are as defined herein. The present invention further provides methods of preparing the inventive stapled polypeptides from unstapled polypeptide precursors. The present invention further provides pharmaceutical compositions comprising a stapled polypeptide of Formula (I) or (VI), and methods of using the stapled peptides. The present invention also provides modifications of the staples post ring closing metathesis.
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公开(公告)号：US10035831B2
公开(公告)日：2018-07-31
申请号：US14898409
申请日：2014-06-13
发明人： Motomu Kanai , Yohei Soma , Atsuhiko Taniguchi , Daisuke Sasaki
CPC分类号： C07K14/4711 , A61K38/00 , C07K1/113
摘要： The invention provides an Aβ peptide aggregation inhibitor, an Aβ peptide toxicity reducing agent, and a preventive and/or therapeutic agent for Alzheimer's disease. The oxidized Aβ peptide in which one or more amino acid residues of Aβ peptide have been oxidized (excluding an oxidized Aβ peptide in which only Met has been oxidized).
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公开(公告)号：US09963492B2
公开(公告)日：2018-05-08
申请号：US15155933
申请日：2016-05-16
CPC分类号： C07K14/4727 , A61K38/00 , C07K1/107 , C07K1/113 , C07K14/47
摘要： Disclosed are protein brushes that mimic mucin in physical and functional characteristics. The protein brushes have a variable number of tandem repeats similar to natural mucin and are modified at a number of their tyrosine residues to introduce brush substituents that mimic the hydrogel nature of mucin.
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公开(公告)号：US20180118859A1
公开(公告)日：2018-05-03
申请号：US15572966
申请日：2016-05-10
CPC分类号： C08F20/60 , A23J3/00 , A23L15/30 , A23V2002/00 , C07K1/113 , C08F20/38 , C12N9/2462 , C12N9/96
摘要： Provided is a protein aggregation inhibitor capable of inhibiting aggregation of a protein even when the protein is heated, and further, capable of inhibiting a decrease in the protein activity even when the protein is heated, which characteristically contains a sulfobetaine polymer obtained by polymerizing monomer components containing sulfobetaine monomer represented by the formula (I): wherein R1 is a hydrogen atom or a methyl group, R2 is an alkylene group having a carbon number of 1-4, R3 is an alkyl group having a carbon number of 1-4, R4 is an alkylene group having a carbon number of 1-4, and X is an —NH— group or an —O— group.
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公开(公告)号：US20170362291A1
公开(公告)日：2017-12-21
申请号：US15532254
申请日：2015-12-21
CPC分类号： C07K14/5428 , C07K1/113
摘要： Methods of enhancing production of cytokines such as IL-10 by, for example, optimizing refolding conditions, are described. The methods provide an efficient, cost-effective means of manufacturing IL-10 on a commercial scale.
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公开(公告)号：US20170253673A1
公开(公告)日：2017-09-07
申请号：US15515936
申请日：2015-09-30
发明人： Christopher KENT , Wilms BAILLE , Marc GAUTHIER , Yi ZHAO , Nicolas COTTENYE
IPC分类号： C07K17/08 , C08G81/02 , C07K1/32 , C07K16/06 , B01D15/38 , C07K1/22 , C07K1/34 , C07K1/36 , B01D15/36 , C07K14/31 , C07K1/113
CPC分类号： C07K17/08 , B01D15/361 , B01D15/3809 , B01D15/3823 , B01D15/3876 , B01D15/388 , C07K1/113 , C07K1/22 , C07K1/32 , C07K1/34 , C07K1/36 , C07K14/195 , C07K14/31 , C07K14/315 , C07K16/00 , C07K16/065 , C07K2317/20 , C07K2317/21 , C07K2317/24 , C07K2319/00 , C08G81/02 , C09D101/12 , C09D101/284 , C09D103/02
摘要： There are provided efficient and cost-effective methods for purifying biomolecules in solution phase using stimuli-responsive protein-polymer conjugates. The protein-polymer conjugates comprise a target biomolecule-binding protein conjugated to a stimuli-responsive polymer and are reusable.
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