公开(公告)号：US12296012B2

公开(公告)日：2025-05-13

申请号：US16617487

申请日：2018-05-31

Applicant: Pfizer Inc.

Inventor： Barbra Johnson Sasu ,  Danielle Elizabeth Dettling ,  Cesar Adolfo Sommer ,  Yik Andy Yeung ,  Moustafa Marc Hamze

IPC: A61K45/06 ,  A61K38/00 ,  A61K39/00 ,  A61K39/395 ,  A61P35/02 ,  C07K14/705 ,  C07K14/715 ,  C07K14/725 ,  C07K16/28

Abstract: Provided herein are antibodies that specifically bind to Fms-like tyrosine kinase 3 (FLT3), chimeric antigen receptors (CARs) that specifically bind to FLT3, and engineered immune cells expressing such CARs (e.g. FLT3-specific CAR-T cells). The invention also provides making such antibodies, CARs, and engineered immune cells. The invention also provides using such antibodies, CARs, and engineered immune cells, for example for the treatment of a condition associated with malignant cells expressing FLT3 (e.g., cancer).

公开(公告)号：US11987634B2

公开(公告)日：2024-05-21

申请号：US17830324

申请日：2022-06-01

Applicant: Pfizer Inc.

Inventor： Siler Panowski ,  Tao Sai ,  Barbra Johnson Sasu ,  Surabhi Srivatsa Srinivasan ,  Thomas John Van Blarcom

IPC: C07K16/28 ,  A61K39/00 ,  A61P35/00

CPC classification number: C07K16/2875 ,  A61P35/00 ,  C07K16/2809 ,  A61K2039/505 ,  C07K2317/31 ,  C07K2317/526 ,  C07K2317/53 ,  C07K2317/565 ,  C07K2317/732 ,  C07K2317/734 ,  C07K2317/76 ,  C07K2317/92

Abstract: The present invention provides antibodies that specifically bind to CD70 (Cluster of Differentiation 70). The invention further provides bispecific antibodies that bind to CD70 and another antigen (e.g., CD3). The invention further relates to antibody encoding nucleic acids, and methods of obtaining such antibodies (monospecific and bispecific). The invention further relates to therapeutic methods for use of these antibodies for the treatment of CD70-mediated pathologies, including cancer.

公开(公告)号：US11912776B2

公开(公告)日：2024-02-27

申请号：US17695769

申请日：2022-03-15

Applicant: Pfizer Inc.

Inventor： Tracy Chia-Chien Kuo ,  Bijan Andre Boldajipour ,  Javier Fernando Chaparro Riggers ,  Philippe Duchateau ,  Roman Galetto ,  Alexandre Juillerat ,  Thomas Charles Pertel ,  Arvind Rajpal ,  Barbra Johnson Sasu ,  Cesar Adolfo Sommer ,  Julien Valton ,  Thomas John Van Blarcom

IPC: C07K14/705 ,  C07K16/28 ,  A61K39/395 ,  A61K39/00 ,  C12N5/10 ,  C07K14/725 ,  A61K31/7076 ,  C12N15/63 ,  A61K35/17 ,  C12N5/0783 ,  A61K38/00

CPC classification number: C07K16/2878 ,  A61K31/7076 ,  A61K35/17 ,  A61K39/0011 ,  A61K39/46 ,  A61K39/4631 ,  A61K39/464417 ,  C07K14/7051 ,  C07K14/70517 ,  C07K14/70578 ,  C07K16/2896 ,  C12N5/0636 ,  C12N5/10 ,  C12N15/63 ,  A61K38/00 ,  A61K2039/505 ,  A61K2039/5156 ,  C07K16/2863 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/569 ,  C07K2317/622 ,  C07K2317/73 ,  C07K2317/92 ,  C07K2319/02 ,  C07K2319/03 ,  C07K2319/33 ,  C12N2510/02

Abstract: The invention provides CARs (CARs) that specifically bind to BCMA (B-Cell Maturation Antigen). The invention further relates to engineered immune cells comprising such CARs, CAR-encoding nucleic acids, and methods of making such CARs, engineered immune cells, and nucleic acids. The invention further relates to therapeutic methods for use of these CARs and engineered immune cells for the treatment of a condition associated with malignant cells expressing BCMA (e.g., cancer).

公开(公告)号：US20220340671A1

公开(公告)日：2022-10-27

申请号：US17695769

申请日：2022-03-15

Applicant: Pfizer Inc.

Inventor： Tracy Chia-Chien KUO ,  Bijan Andre Boldajipour ,  Javier Fernando Chaparro Riggers ,  Philippe Duchateau ,  Roman Galetto ,  Alexandre Juillerat ,  Thomas Charles Pertel ,  Arvind Rajpal ,  Barbra Johnson Sasu ,  Cesar Adolfo Sommer ,  Julien Valton ,  Thomas John Van Blarcom

IPC: C07K16/28 ,  C07K14/725 ,  C07K14/705 ,  A61K39/00 ,  A61K31/7076 ,  C12N15/63 ,  A61K35/17 ,  C12N5/10 ,  C12N5/0783

Abstract: The invention provides CARs (CARs) that specifically bind to BCMA (B-Cell Maturation Antigen). The invention further relates to engineered immune cells comprising such CARs, CAR-encoding nucleic acids, and methods of making such CARs, engineered immune cells, and nucleic acids. The invention further relates to therapeutic methods for use of these CARs and engineered immune cells for the treatment of a condition associated with malignant cells expressing BCMA (e.g., cancer).

公开(公告)号：US11377500B2

公开(公告)日：2022-07-05

申请号：US16264485

申请日：2019-01-31

Applicant: Pfizer Inc.

Inventor： Siler Panowski ,  Tao Sai ,  Barbra Johnson Sasu ,  Surabhi Srivatsa Srinivasan ,  Thomas John Van Blarcom

IPC: C07K16/28 ,  A61P35/00 ,  A61K39/00

Abstract: The present invention provides antibodies that specifically bind to CD70 (Cluster of Differentiation 70). The invention further provides bispecific antibodies that bind to CD70 and another antigen (e.g., CD3). The invention further relates to antibody encoding nucleic acids, and methods of obtaining such antibodies (monospecific and bispecific). The invention further relates to therapeutic methods for use of these antibodies for the treatment of CD70-mediated pathologies, including cancer.

公开(公告)号：US11312782B2

公开(公告)日：2022-04-26

申请号：US16384719

申请日：2019-04-15

Applicant: Pfizer Inc.

Inventor： Tracy Chia-Chien Kuo ,  Bijan Andre Boldajipour ,  Javier Fernando Chaparro Riggers ,  Philippe Duchateau ,  Roman Ariel Galetto ,  Alexandre Juillerat ,  Thomas Charles Pertel ,  Arvind Rajpal ,  Barbra Johnson Sasu ,  Cesar Adolfo Sommer ,  Julien Valton ,  Thomas John Van Blarcom

IPC: C12N5/10 ,  C12N15/63 ,  C07K16/28 ,  C07K14/705 ,  C07K19/00 ,  C07K14/725 ,  A61K39/00 ,  A61K31/7076 ,  A61K35/17 ,  C12N5/0783 ,  A61K39/395 ,  A61K38/00

Abstract: The invention provides CARs (CARs) that specifically bind to BCMA (B-Cell Maturation Antigen). The invention further relates to engineered immune cells comprising such CARs, CAR-encoding nucleic acids, and methods of making such CARs, engineered immune cells, and nucleic acids. The invention further relates to therapeutic methods for use of these CARs and engineered immune cells for the treatment of a condition associated with malignant cells expressing BCMA (e.g., cancer).