公开(公告)号：US20170224804A1

公开(公告)日：2017-08-10

申请号：US15347034

申请日：2016-11-09

Applicant: PFIZER INC.

Inventor： Jianxin Gu ,  Jin-hwan Kim ,  Avvari Krishna Prasad ,  Yu-ying Yang

IPC: A61K39/095 ,  A61K39/09

CPC classification number: A61K39/095 ,  A61K39/092 ,  A61K45/06 ,  A61K47/64 ,  A61K47/6415 ,  A61K47/646 ,  A61K2039/6037 ,  A61K2039/6068 ,  A61K2039/627

Abstract: The invention provides eTEC linked glycoconjugates comprising a saccharide covalently conjugated to a carrier protein through a (2-((2-oxoethyl)thio)ethyl)carbamate (eTEC) spacer, immunogenic compositions comprising such glycoconjugates, and methods for the preparation and use of such glycoconjugates and immunogenic compositions.

公开(公告)号：US20150216996A1

公开(公告)日：2015-08-06

申请号：US14420822

申请日：2013-08-12

Applicant: PFIZER INC.

Inventor： Jianxin Gu ,  Jin-hwan Kim ,  A. Krishna Prasad ,  Yu-ying Yang

IPC: A61K47/48 ,  A61K45/06 ,  A61K39/09

CPC classification number: A61K39/095 ,  A61K39/092 ,  A61K45/06 ,  A61K47/64 ,  A61K47/6415 ,  A61K47/646 ,  A61K2039/6037 ,  A61K2039/6068 ,  A61K2039/627

Abstract: The invention provides eTEC linked glycoconjugates comprising a saccharide covalently conjugated to a carrier protein through a (2-((2-oxoethyl)thio)ethyl)carbamate (eTEC) spacer, immunogenic compositions comprising such glycoconjugates, and methods for the preparation and use of such glycoconjugates and immunogenic compositions.

Abstract translation: 本发明提供了包含通过（2 - （（2-氧代乙基）硫基）乙基）氨基甲酸酯（eTEC）间隔物共价结合载体蛋白质的糖的eTEC连接的糖缀合物，包含这种糖缀合物的免疫原性组合物，以及制备和使用 这样的糖缀合物和免疫原性组合物。